Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Review Article Volume 5 Issue 5

Effect of Ulipristal Acetate on Uterine Fibroid Angiogenesis, Measured by 2D Power Doppler Ultrasound and Serum VEGF Levels

Manuel Garcia Manero*

Department of Obstetrics and Gynecology, Hospital García Orcoyen, Calle Santa Soria, Spain

*Corresponding Author: Manuel Garcia Manero, Department of Obstetrics and Gynecology, Hospital García Orcoyen, Calle Santa Soria, Spain.

Received: October 4, 2022; Published: April 12, 2023


Introduction: Uterine fibroids are a frequent pathology in women of reproductive age responsible for a variety of symptoms that can become disabling. Ulipristal Acetate is a medical treatment that causes a decrease in the size of the fibroid, improving symptoms. In this study we evaluated the correlation between the vascularization of the fibroid measured by ultrasound (Power Doppler 2D) and the levels of VEGF in serum, before and after treatment with ulipristal acetate in patients diagnosed with symptomatic uterine fibroids.

Material and Method: A prospective observational study was designed. Twenty-four premenopausal women, previously diagnosed with symptomatic uterine fibroids, were included and all completed the study. Four cycles of Ulipristal Acetate were administered according to the dose and indications specified in the data sheet. To assess the influence of this treatment on the fibroid angiogenesis process, serum VEGF levels were measured and its vascularization was assessed by 2d Power Doppler ultrasound; at the beginning and at the end of treatment. In addition, in successive visits several determinations of the same parameters were made. Parameters were defined as the decrease in VEGF levels from previous levels,

Results: 24 patients who met the inclusion criteria (n = 24) were recruited. The average size of the fibroids was reduced from 45.08 ± 24.02 mm to 29.00 mm-+-16.96 mm after treatment. The mean serum level of VEGF decreased significantly after the first cycle of treatment (from 147.17 ± 153.51 pg/mL to 102.04 ± 186.08 pg/ml). The vascularization of the fibroids was analyzed after treatment with Ulipristal Acetate, and a significant decrease was achieved in 83.3% of the cases.

Conclusions: There is a correlation between decreased vascularization of fibroids and treatment with Ulipristal Acetate. Selective Progesterone Receptor Modulators can provide effective treatment for women with symptomatic fibroids in two ways: by blocking selective progesterone receptor modulators and by reducing angiogenesis.

Keywords: Angiogenesis; Ulipristal Acetate; Uterine Fibroids; VEGF Doppler Ultrasound


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Citation: Manuel Garcia Manero. “Effect of Ulipristal Acetate on Uterine Fibroid Angiogenesis, Measured by 2D Power Doppler Ultrasound and Serum VEGF Levels". Acta Scientific Women's Health 5.5 (2023): 18-24.


Copyright: © 2023 Manuel Garcia Manero. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
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