Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Review Article Volume 5 Issue 3

Innovative Therapeutic Strategies for the Treatment of Repeated Implantation Failure - An Update

Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3

1Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyan and Hospital, Jalandhar, Punjab, India

*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.

Received: October 27, 2022; Published: February 06, 2023

Abstract

Inspite of the hurdles in evaluation of Recurrent implantation failure, there has been forward progression existent with regards to therapeutic strategies for aiding in these RIF patients. Of the maximum attractive approaches three like utilization of I) peripheral blood mononuclear cells (PBMC), ii) Subcutaneous administration of Granulocyte Colony –Stimulating Facto (G-CSF)r iii) Platelet rich plasma (PRP) hold major attraction. Here we have Concentrated mainly on these 3 innovative strategies besides detailing certain other immune therapies utilized in the past like Intrauterine Insemination of hCG, ii) intravenous immuoglobulins (IVIG), iii) intravenous intralipid as well as iv)heparin in addition to how they act.

Keywords: Recurrent Implantation Failure; PBMC; PRP; G-CSF

References

  1. Fujiwara H. “Immune cells contribute to systemic crosstalk between the embryos and mother during early pregnancy in cooperation with the endocrine system”. Reproductive Medicine and Biology 5 (2006): 19-29.
  2. Yu N., et al. “Followed by administration of autologous peripheral blood mononuclear cells (PBMC) activated by HCG improves the implantation and pregnancy rates in patients with repeated implantation failure: a prospective randomized study”. American Journal of Reproductive Immunology 76 (2016): 212-216.
  3. Madkour A., et al. “Intrauterine semination of cultured treated peripheral blood mononuclear cells prior to embryo transfer improves Clinical outcomes for patients with repeated implantation failure”. Zygote 24 (2016): 58-69.
  4. Nobjiari H., et al. “Endometrium immunomodulation by Intrauterine insemination administration of treated peripheral blood mononuclear cells prior to frozen embryo transfer in patients with repeated implantation failure”. Zygote 27 (2019): 214-218.
  5. Yoshioka S., et al. “Intrauterine administration of autologous peripheral blood mononuclear cells promote implantation rates in patients with repeated implantation failure of IVF-embryo transfer”. Human Reproduction 21 (2006): 3290-3294.
  6. Okitsu O., et al. “Intrauterine administration of autologous peripheral blood mononuclear cells increases Clinical pregnancy rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure”. Journal of Reproductive Immunology 92 (2011): 82-87.
  7. Turocy J., et al. “Novel therapeutic options for treatment of Recurrent implantation failure”. Fertility and Sterility 116 (2021): 1449-1454.
  8. Li S., et al. “Intrauterine administration of hCG activated autologous peripheral blood mononuclear cells (PBMC) promotes live birth rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure”. Journal of Reproductive Immunology 119 (2017): 15-22.
  9. Busneli A., et al. “Efficacy of therapies and repeated interventions for repeated implantation failure. a systematic review and meta-analysis”. Scientific Report 11 (2021): 1747.
  10. Nazari L., et al. “Effects of autologous platelet rich plasma on Endometrial expansion in patients undergoing frozen/thawed embryo transfer: a double RCT”. International Journal of Reproductive BioMedicine 17 (2019): 443-448.
  11. Kulvinder Kochar Kaur., et al. “Autologous Platelet rich plasma (PRP) :A Possibility of becoming a revolutionary therapy in the field of Gynaecology and reproductive Endocrinology and Infertility-A Systematic Review”. Progress in Women's Health Care1 (2019): 1-13.
  12. Kramer ME and Keaney TC. “Systematic review of platelet rich plasma (PRP) preparation and composition for the treatment of androgenic alopecia”. Journal of Cosmetic Dermatology 17 (2018): 666-671.
  13. Dhillon RS., et al. “Platelet rich plasma therapy -future or trend?” Arthritis Research Therapy 14 (2012): 219.
  14. Eftikhar M., et al. “Can autologous platelet rich plasma expand Endometrial thickness and improve pregnancy rates during frozen thawed embryo transfer cycle? a randomized Clinical trial”. Taiwanese Journal of Obstetrics and Gynecology 57 (2018): 810.
  15. Nazari L., et al. “The effects of autologous platelet rich plasma in repeated implantation failure : a randomized controlled trial”. Human Fertility (Camb) 23 (2020): 209-213.
  16. Zamaniyan M., et al. “Effects of platelet rich plasma on pregnancy outcomes in infertile women with Recurrent implantation failure: a randomized controlled trial”. Gynecology and Endocrinology 37 (2021): 141-145.
  17. Kamath MS., et al. “Granulocyte Colony –Stimulating Factor administration for sub fertile women undergoing assisted reproduction”. Cochrane Database System Review 1 (2020): CD013226.
  18. Smith TJ., et al. “Recommendations for the use of WBC growth factors : American Society of Clinical Oncology, Clinical Practice Guidelines Update”. Journal of Clinical Oncology 33 (2015): 3199-3212.
  19. Shaulov T., et al. “Recurrent implantation failure in IVF:A Canadian Fertility and Andrology Society, Clinical Practice Guidelines”. Reproductive BioMedicine Online 41 (2020): 819-833.
  20. Aleyasi N., et al. “Granulocyte Colony–Stimulating Factor in repeated IVF failure :a randomized trial”. Reproduction 151 (2016): 637-642.
  21. Scarpelini F and Sbracia M. “The use of G-CSF for implantation failure: a Clinical trial”. Fertility and Sterility 96 (2011): S93.
  22. Kalem Z., et al. “Intrauterine G-CSF administration in Recurrent implantation failure: a randomized double blind placebo control trial”. International Journal of Reproductive BioMedicine 14 (2016): 737-742.
  23. Scarpelini F and Sbracia M. “The use of G-CSF treatment improves IVF outcomes in women with Recurrent implantation failure”. Journal of Reproductive Immunology 103 (2012).
  24. Liu X., et al. “Intrauterine administration of human chorionic Gonadotropins improves the live birth rates of patients with repeated implantation failure”. American Journal of Reproductive Immunology 79 (2018).
  25. Ho YK., et al. “Peripheral CD 56 NK cell populations in the early follicular phase are associated with successful Clinical outcomes of intravenous immuoglobulins in women with repeated implantation failure”. Frontiers in Endocrinology (Lausanne) 10 (2019): 937.
  26. AlZabewidy J., et al. “Effects of empiric intravenous intralipid therapy on pregnancy outcomes in women with unexplained Recurrent implantation failure undergoing Intracytoplasmic sperm injection- embryo transfer: randomized controlled trial”. Gynecology and Endocrinology 36 (2020): 131-134.
  27. Gao M., et al. “Intrauterine injections of human chorionic Gonadotropins before embryo transfer can improve in vitro fertilization - embryo transfer outcomes :a meta-analysis of randomized controlled trials”. Fertility and Sterility 112 (2019): 89-97.e1.
  28. Morau M., et al. “Intravenous immuoglobulins treatment increased live birth rates in a Spanish cohort of women with Recurrent Reproductive failure and expanded CD 56 (+)cells”. American Journal of Reproductive Immunology 68 (2012): 75-84.
  29. Ramos-Medina R., et al. “Experience of IVIG therapy for selected women with Recurrent Reproductive failure and NK cell expansion”. American Journal of Reproductive Immunology 71 (2014): 458-466.
  30. Singh N., et al. “The effects of administration of intravenous intralipid on pregnancy outcomes in women with implantation failure after IVF/ ICSI with non donor oocytes :a randomized controlled trial”. Journal of Obstetrics and Gynecology and Reproductive Biology 240 (2019): 45-51.
  31. Lodigani C., et al. “The effects of parnaprin sodium on in vitro fertilization outcomes :A prospective randomized controlled trials”. Thrombosis Research 159 (2017): 116-121.
  32. Berker B., et al. “The role of low molecular weight heparin Recurrent implantation failure: A prospective quasi- randomized controlled study”. Fertility and Sterility 95 (2011): 2409-2502.
  33. Kulvinder Kochar Kaur., et al. “Management of Cases of Resistant Endometrium in Recurrent Implantation Failure Using Endometrial Mesenchymal Stem Cells as an Innovative Regenerative Therapy-A Short Communication”. Journal of Regenerative Medicine and Biology Research 1 (2010): 1-12.
  34. Pirtea P., et al. “Rate of true Recurrent implantation failure is low :results of three successive frozen euploid Single embryo transfers”. Fertility and Sterility 115 (2021): 45-53.

Citation

Citation: Kulvinder Kochar Kaur., et al. “Innovative Therapeutic Strategies for the Treatment of Repeated Implantation Failure - An Update". Acta Scientific Women's Health 5.3 (2023): 24-30.

Copyright

Copyright: © 2022 Kulvinder Kochar Kaur., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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