Improvement of Primary Dysmenorrhea with Oral Dose of Vitamin D: A Pilot Study
Manuel Garcia Manero1*, Nicolas Garcia Goyenecha2, Miguel Alvarez2 and Itaxo Salinas2
1Centro De Trabajo, Hospital Garcia Orcoyen (SNS-Osasunbidea), Spain
2Facultad De Medicina, Universidad de Navarra, Spain
*Corresponding Author: Manuel Garcia Manero, Centro De Trabajo, Hospital Garcia Orcoyen (SNS-Osasunbidea), Spain.
December 13, 2022; Published: February 05, 2023
Primary dysmenorrhea is a common disorder characterized by painful uterine cramping, just before or during menstruation, in the absence of any pelvic pathologic conditions. It is frequently accompanied by other symptoms such as nausea, vomiting, diarrhea, asthenia, and insomnia.
An excessive uterine production of prostaglandins (PGs) is the pathogenetic trigger of dysmenorrhea. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the currently accepted drugs for the management of this disorder.
Because the vitamin D receptor is widespread and the mitochondrial cytochrome P450 enzyme 25-hydroxyvitamin D3 (25[OH]D)-1α-hydroxylase (1α-OHase), which catalyzes the synthesis of 1α,25-dihydroxyvitamin D3 (1,25[OH]2D) from its precursor 25(OH)D, is expressed in the human uterus and in immune system cells, and because vitamin D reduces the synthesis of PGs, a beneficial effect of vitamin D in the uterus pathophysiology is possible.
We evaluated the effect of vitamin D supplementation on individuals in 3 categories: individuals with mild dysmenorrhea; moderate dysmenorrhea and severe dysmenorrhea.
The aim of this intervention study was to evaluate the effect of oral dose of cholecalciferol (2 000 IU) on primary dysmenorrhea
Keywords: Vitamin D; Dysmenorrhea
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