Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Research Article Volume 5 Issue 1

Polycystic Ovary Syndrome: Effect of Inositols and Lipid Mediators. Pilot Study

García Manero Manuel*, Ceamanos Montañes Carolina, Campo Ainhoa, Peru Gema

Department of Obstetrics and Gynecology, Hospital García Orcoyen, Estella, Navarra, Spain

*Corresponding Author: García Manero Manuel, Department of Obstetrics and Gynecology, Hospital García Orcoyen, Estella, Navarra, Spain.

Received: September 14, 2022; Published: December 30, 2022


Objective: to evaluate the effect of the combination of inositiol derivatives and lipid mediators on the metabolic and inflammatory profile of women with polycystic ovary syndrome.

Material and Methods: Experimental, prospective and longitudinal study carried out in patients diagnosed with polycystic ovary syndrome (Rotterdam criteria) without treatment or previous dietary intervention. The following nutritional preparations were administered orally daily:

  • Group A: 300mg D-chiro-inositol, 1099mg myo- inositol + 30mg lipinova
  • Group B: 4000 mg of myo -inositol + 30 mg of lipinova

The metabolic profile is compared before and after 4 weeks of treatment in each patient, determining the insulin levels and the HOMA index. The inflammatory profile was analyzed by determining the levels of IL-6 before and after treatment.


  • 41 patients with polycystic ovary syndrome subdivided into 20 from group A and 21 from group B were studied.
  • Insulin levels before and after treatment were 17.9 +-9.3 SD and 10 +-4.09 SD, respectively, with statistically significant differences.
  • The HOMA index pre-treatment was 4.1 +-2.1 SD and 2.1+- 1.1 SD post-treatment, with significant differences
  • The level of IL-6 was pretreatment was 3.8 +- 1.5 Sd of 2.1 + -1.09 post treatment with significant differences

Conclusion: The results of the study show the positive effect of the combined administration of inositolic derivatives and pro-resolution lipid mediators on the metabolic, clinical and inflammatory profile of patients with polycystic ovary syndrome.

Keywords: Pro-Resolving Lipid Mediators; Inositol; Polycystic Ovary


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Citation: García Manero Manuel., et al. “Polycystic Ovary Syndrome: Effect of Inositols and Lipid Mediators. Pilot Study". Acta Scientific Women's Health 5.1 (2023): 45-56.


Copyright: © 2022 García Manero Manuel., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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