O Laba and V Pyrohova*

Danylo Halytskyi Lviv National Medical University, Ukraine

*Corresponding Author: V Pyrohova, Danylo Halytskyi Lviv National Medical University, Ukraine.

Received: October 27, 2022; Published: December 07, 2022

Abstract

In etiopathogenetic terms, premature birth is considered as a clinical syndrome characterized by polyetiological factors, the participation of the fetus in pathogenesis, a variety of clinical symptoms, and the involvement of genetic and environmental factors. At the same time, there is increasing evidence that the composition of a woman's vaginal microbiota significantly affects her sexual and reproductive health, including the risk of adverse pregnancy outcomes, including miscarriage and preterm birth. The purpose of the work was to assess the state of the vaginal microbiota in women with risk factors and the threat of spontaneous premature birth. 150 women of reproductive age took part in the study. The inclusion criteria for the study were the presence of risk factors for preterm birth or the threat of preterm birth. Determination of the pH of vaginal contents, molecular biological, and bacterioscopic methods were used to assess the state of the vaginal microbiota.

The conducted studies indicate a high risk of preterm birth in the presence of dysbiotic and inflammatory changes in the vaginal microbiota - odds ratio (OR) = 2.962 (95% CI 1.32-6.645). At the same time, for pregnant women with risk factors for preterm birth, OR makes up = 8.120 (95% CI 2.149-30.686), and for pregnant women with diagnosed threatened preterm birth - OR = 10.133 (95% CI 3.149-32.604). Thus, one of the risk factors for the development of spontaneous premature and threatened premature births is changes in the state of the vaginal microbiota, which requires the development of diagnostic and therapeutic measures to prevent premature termination of pregnancy and reduce the frequency of obstetric and perinatal complications.

Keywords: Preterm Labor; Vaginal Microbiota; Bacterial Vaginosis; Aerobic (Mixed) Vaginitis; Vaginal Dysbiosis

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Citation

Citation: O Laba and V Pyrohova. “Study of the State of the Vaginal Microbiota in Women with Risk and Threat of Preterm Birth". Acta Scientific Women's Health 5.1 (2023): 12-18.

Copyright

Copyright: © 2022 O Laba and V Pyrohova. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.