Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Research Article Volume 4 Issue 7

The Relationship Between Leptin Levels and the Leptin Gene Promoter Polymorphism G-2548A at the Onset of Preeclampsia

Roza Sriyanti1*, Masrul2, Johanes C Mose3 and Netti Suharti4

1Division of Maternal - Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University/Dr. M. Djamil Central General Hospital, Padang, Indonesia
2Department of Nutrition, Andalas University, Padang, Indonesia
3Division of Maternal - Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University/Hasan, Sadikin, Bandung, Indonesia
4Department of Microbiology, Andalas University, Padang, Indonesia

*Corresponding Author: Roza Sriyanti, Division of Maternal - Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University/Dr. M. Djamil Central General Hospital, Padang, Indonesia.

Received: April 14, 2022; Published: June 28, 2022

Abstract

Introduction: Preeclampsia is one of the complications of pregnancy that often increases maternal morbidity and mortality. The influence of the leptin gene promoter polymorphism G-2548A plays a role in the development of preeclampsia.

Objective: This study was to determine the relationship between leptin levels and the leptin gene promoter polymorphism G-2548A at the onset of preeclampsia.

Methods: This study used a cross sectional comparative study design which was conducted from May 2018 - April 2019 in the Obstetrics and Gynecology section/SMF of General Hospital Dr. M. Djamil Padang, Achmad Mochtar Hospital, Solok Hospital, Reksodiwiryo Hospital. Sampling with consecutive sampling consisting of 69 pregnant women met the inclusion and exclusion criteria. Examination of the promoter polymorphism of the G-2548A leptin gene was carried out by sequencing method.

Results: From the results of the study, the highest leptin levels were found in EOPE compared to LOPE and normal pregnancies. In EOPE, the highest leptin levels were found in the AA genotype (52.81 ± 66.14), in LOPE it was found in the GG genotype (47.40 ± 44.29), and in normal pregnancy the highest leptin levels were found in the AA genotype (18.78 ± 29.75).

Conclusion: There was no significant relationship between leptin levels and the leptin gene promoter polymorphism G-2548A at the onset of preeclampsia.

Keywords: Early Onset Preeclampsia; Leptin Levels; Leptin Gene Promoter Polymorphism

References

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Citation

Citation: Roza Sriyanti., et al. “The Relationship Between Leptin Levels and the Leptin Gene Promoter Polymorphism G-2548A at the Onset of Preeclampsia". Acta Scientific Women's Health 4.7 (2022): 90-94.

Copyright

Copyright: © 2022 Roza Sriyanti., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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