Roza Sriyanti¹*, Masrul², Johanes C Mose³ and Netti Suharti⁴

¹Division of Maternal - Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University/Dr. M. Djamil Central General Hospital, Padang, Indonesia
²Department of Nutrition, Andalas University, Padang, Indonesia
³Division of Maternal - Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University/Hasan, Sadikin, Bandung, Indonesia
⁴Department of Microbiology, Andalas University, Padang, Indonesia

*Corresponding Author: Roza Sriyanti, Division of Maternal - Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University/Dr. M. Djamil Central General Hospital, Padang, Indonesia.

Received: April 14, 2022; Published: June 28, 2022

Abstract

Introduction: Preeclampsia is one of the complications of pregnancy that often increases maternal morbidity and mortality. The influence of the leptin gene promoter polymorphism G-2548A plays a role in the development of preeclampsia.

Objective: This study was to determine the relationship between leptin levels and the leptin gene promoter polymorphism G-2548A at the onset of preeclampsia.

Methods: This study used a cross sectional comparative study design which was conducted from May 2018 - April 2019 in the Obstetrics and Gynecology section/SMF of General Hospital Dr. M. Djamil Padang, Achmad Mochtar Hospital, Solok Hospital, Reksodiwiryo Hospital. Sampling with consecutive sampling consisting of 69 pregnant women met the inclusion and exclusion criteria. Examination of the promoter polymorphism of the G-2548A leptin gene was carried out by sequencing method.

Results: From the results of the study, the highest leptin levels were found in EOPE compared to LOPE and normal pregnancies. In EOPE, the highest leptin levels were found in the AA genotype (52.81 ± 66.14), in LOPE it was found in the GG genotype (47.40 ± 44.29), and in normal pregnancy the highest leptin levels were found in the AA genotype (18.78 ± 29.75).

Conclusion: There was no significant relationship between leptin levels and the leptin gene promoter polymorphism G-2548A at the onset of preeclampsia.

Keywords: Early Onset Preeclampsia; Leptin Levels; Leptin Gene Promoter Polymorphism

References

1. Rigó Jr János., et al. "Leptin receptor gene polymorphisms in severely pre-eclamptic women”. Gynecological Endocrinology9 (2006): 521-525.
2. Salimi Saeedeh., et al. "Different profile of serum leptin between early onset and late onset preeclampsia”. Disease Markers 2014 (2014).
3. Cunningham F Gary., et al. "Hypertensive disorders”. Williams obstetrics 24 (2014): 728-9.
4. MacKay Andrea P., et al. "Pregnancy-related mortality from preeclampsia and eclampsia”. Obstetrics and Gynecology4 (2001): 533-538.
5. Von Dadelszen., et al. "Subclassification of preeclampsia”. Hypertension in Pregnancy2 (2003): 143-148.
6. Ogge Giovanna., et al. "Placental lesions associated with maternal under perfusion are more frequent in early-onset than in late-onset preeclampsia”. Journal of Perinatal Medicine6 (2011): 641-652.
7. Van der Merwe JL., et al. "Are early and late preeclampsia distinct subclasses of the disease—what does the placenta reveal?”. Hypertension in Pregnancy4 (2010): 457-467.
8. Sulistyowati Sri. "Early and late onset preeclamsia: What did really matter”. Journal of Gynecology Women’s Health4 (2017): 555670.
9. Sugathadasa B H K R., et al. "Association of–2548 G/A Polymorphism in the Leptin Gene with Preeclampsia/Pregnancy-Induced Hypertension”. Hypertension in Pregnancy4 (2010): 366-374.
10. Bienertová‐Vašků Julie., et al. "Is there any link between severe pre‐eclampsia and defined polymorphisms in leptin and adiponectin genes?”. Journal of Obstetrics and Gynaecology Research5 (2008): 858-864.
11. Carrillo-Vazquez Jonathan P., et al. "G-2548A leptin promoter and Q223R leptin receptor polymorphisms in obese Mexican subjects”. American journal of agricultural and biological science (2013): 34-43.
12. Farias Dayana R., et al. "Polymorphisms of leptin (G2548A) and leptin receptor (Q223R and K109R) genes and blood pressure during pregnancy and the postpartum period: a cohort”. American Journal of Hypertension2 (2017): 130-140.
13. Liu Y., et al. "Role of leptin receptor gene polymorphisms in susceptibility to the development of essential hypertension: a case–control association study in a Northern Han Chinese population”. Journal of Human Hypertension9 (2014): 551-556.

Citation

Citation: Roza Sriyanti., et al. “The Relationship Between Leptin Levels and the Leptin Gene Promoter Polymorphism G-2548A at the Onset of Preeclampsia". Acta Scientific Women's Health 4.7 (2022): 90-94.

Copyright

Copyright: © 2022 Roza Sriyanti., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.