Effects of Quercetin Nanoparticles, An Antioxidant Bioflavonoid on the Retina of STZ-induced Diabetic Rats
Anhar M Gomaa1, Soheir N Abd El-Rahman2* and Suhailah S Al-Jameel3
1Research Institute of Ophthalmology, Giza, Egypt
2Crops Technology Research Department, Food Technology Research Institute, Agricultural Research Center, Giza, Egypt
3Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Saudi Arabia
*Corresponding Author: Soheir N Abd El-Rahman, Crops Technology Research Department, Food Technology Research Institute, Agricultural Research Center, Egypt, Mail:firstname.lastname@example.org, https://orcid.org/0000-0001-8056-254.
April 19, 2022; Published: June 17, 2022
The retina is susceptible to oxidative stress due to an increase in free radicals or deficiency in natural antioxidants, induced in diabetic retinopathy. So, this study is aimed to examine the beneficial effect of Quercetin Nanoparticles (QUNPs) to protect the retina against diabetic rats and its oxidative stress. Diabetic rats were treated with QUNPs (5 and 10 mg/kg BW) for 8 weeks, then the fasting blood sugar (FBS), lipid markers (TC, TG, LDL-c, and HDL-c), were determined at the end of the experiment. Superoxide dismutase; (SOD), Catalase; (CAT) activities; in addition to glutathione; (GSH) and malondialdehyde (MDA) were determined in the blood and retina. Histological changes in the retina were evaluated by a light microscopic (LM) study. Our results revealed that QUNPs treatment for diabetic rats caused a significantly decreased in FBS, TC, TG, LDL-c levels. Also, a highly significant increase in HDL-c level was noticed. QUNPs (10 mg/kg BW) +STZ (60 mg/kg BW) group results are the same more or less normal values in MDA, CAT, SOD, and GSH compared to a positive control (PC) and positive modulation of anti-oxidant enzyme activity was noticed. Moreover, QUNPs treatment which was an effective antioxidant did not have negative effects on the health of rats. Light microscopic study showed thickness increased in basement membrane in the diabetic retina, while relatively thin LM was observed in QUNPs 5 and 10 mg/kg BW- retina treated group. It can be concluded that QUNPs can be effective for the protection of diabetes-induced neurovascular complications such as diabetic retinopathy. Therefore, our study suggests that QUNPs can play an important role as natural nano-antioxidant of oxidative stress in diabetic retinopathy.
Keywords:Diabetic Retinopathy; Oxidative Stress; Quercetin Nanoparticles; Streptozotocin (STZ)
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