Agnes Immanuel¹, Sarat Battina² and Reeta Janet Jessy³*

¹Senior Embryologist, Indigo Women Center, India
²Director of Reproductive Medicine, Indigo Women Center, India
³M.sc Zoology, India

*Corresponding Author: Reeta Janet Jessy, M.sc Zoology, India.

Received: January 21, 2022; Published: January 27, 2022

Abstract

IVF treatments highly motivate infertility patients to achieve pregnancy. The decades ago worldwide the researchers performed day 2 or day 3 transfers in order to increase the pregnancy success rate. The embryologists selected randomly the 3-4embryos on the basis of cleavage. So it often easily leads to multiple pregnancy (triplet or quadruplet) and it reaches at high risk of life threatening premature newborn. Slowly the researchers were moved on extending culture from day 3 to day 5, blastocyst stage to avoid the risk of multiple pregnancy. Then it was recognised as the survival of good quality embryos percentage is higher to the fifth or sixth day of post insemination. Likely, the selection of one or two good embryos is based on the formation of blastocyst. Ultimately it leads to higher pregnancy rate. To optimise the success rate the grading and selection of embryos are eventually needed. The advantage of blastocyst transfer includes better synchronisation between endometrium lining and the blastocyst. The endometrium is the inner line of the uterus. Every month of the female menstrual cycle the endometrium size will be changing their thickness. The progesterone and oestrogen plays a major role for the endometrium thickness. The growth and shedding of the endometrium through menstruation cycle the pregnancy does not occur. The ultrasound monitoring is necessary for the measurement of the endometrium line. The endometrium thickness is necessary and this acts as host of the embryo. The aim of this study was to compare between the conventional blastocyst transfer and blastocyst transfer after ERA biopsy.

Keywords: Infertility; Pregnancy; Endometrium

References

1. Dorostghoal M., et al. “Over expression of endometrial oestrogen receptor-alpha in the window of implantation in women with unexplained infertility”. International Journal of Fertility and Sterility 12 (2018): 37-42.
2. Lessey BA., et al. “Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women”. Reproductive Biology and Endocrinology 4 (2006): S9.
3. Lee DK., et al. “Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization”. Molecular Endocrinology 24 (2010): 930-940.
4. Zhang P., et al. “Transcriptome profiling of human pre-implantation development”. PLoS ONE 4 (2009): e7844.
5. Sasaki H. “Position- and polarity-dependent Hippo signalling regulates cell fates in preimplantation mouse embryos”. Seminars in Cell and Developmental Biology (2015): 47-48, 80-87.
6. Rayon T., et al. “Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst”. Developmental Cell 30 (2014): 410-422.
7. Tesarik J., et al. “Paternal effects acting during the first cell cycle of human preimplantation development after ICSI”. Human Reproduction 17 (2002): 184-189.
8. Tsirigotis M. “Blastocyst stage transfer: pitfalls and benefits”. Human Reproduction 13 (1998): 3285-3289.
9. Vanderzwalmen P., et al. “Sperm morphology and IVF pregnancy rate: comparison between Percoll gradient centrifugation and swim-up procedures”. Human Reproduction 6 (1991): 581-588.

Citation

Citation: Reeta Janet Jessy., et al. “Impact of Endometrium Receptivity on Blastocyst Transfer". Acta Scientific Women's Health 4.2 (2022): 43-45.

Copyright

Copyright: © 2022 Reeta Janet Jessy., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.