Abstract

Melasma is a disfiguring skin disease that is often challenging to treat. Treatments options including topical remedies, laser therapies and systemic medications vary widely in efficacy and tend to display safety concerns. Systemic tranexamic acid has been widely feared in practice as a treatment option, despite growing evidence in literature of its high efficacy and safety in the management of melasma. In this article, we discuss the efficacy and safety of oral tranexamic acid in the treatment of melasma.

Keywords: Melasma; Chloasma; Tranexamic Acid; Hydroquinone; Tretinoin

References

1. Passeron T and Picardo M. “Melasma, a photoaging disorder”. Pigment Cell and Melanoma Research4 (2018): 461-465.
2. McKesey J., et al. “Melasma Treatment: An Evidence-Based Review”. American Journal of Clinical Dermatology 2 (2019): 173-225.
3. Kwon S., et al. “Melasma: Updates and perspectives”. Experimental Dermatology6 (2018): 704-708.
4. Gupta A., et al. “The treatment of melasma: A review of clinical trials”. Journal of the American Academy of Dermatology6 (2006): 1048-1065.
5. Dunn C and Goa K. “Tranexamic Acid”. Drugs6 (1999): 1005-1032.
6. Sheu S. “Treatment of melasma using tranexamic acid: what's known and what's next”. Cutis 2 (2018): E7-E8.
7. Na J., et al. “Effect of tranexamic acid on melasma: a clinical trial with histological evaluation”. Journal of the European Academy of Dermatology and Venereology8 (2012): 1035-1039.
8. Meaidi A., et al. “Oral tranexamic acid and thrombosis risk in women”. EClinicalMedicine (2021): 100882.
9. Zhang L., et al. “Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis”. BioMed Research International (2018): 1-13.
10. Lee H., et al. “Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis”. Journal of the American Academy of Dermatology 2 (2016): 385-392.
11. Bala H., et al. “Oral Tranexamic Acid for the Treatment of Melasma: A Review”. Dermatologic Surgery6 (2018): 814-825.
12. Kaur A., et al. “Tranexamic acid in melasma: a review”. com (2021).
13. org.uk. Tranexamic Acid 500 mg film coated tablets - Summary of Product Characteristics (SmPC) - (emc) (2021).

Citation

Citation: Mohammed Al Abadie., et al. “The Efficacy and Safety of Oral Tranexamic Acid (TXA) in the Treatment of Melasma”. Acta Scientific Women's Health 3.10 (2021):.

Copyright

Copyright: © 2021 Mohammed Al Abadie., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.