Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Short Communication Volume 3 Issue 9

Endocervical Adenocarcinoma: A Paradigm Shift in Classification

Nilay Nishith*

Senior Resident, Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

*Corresponding Author: Nilay Nishith, Senior Resident, Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Received: August 05, 2021; Published: August 19, 2021

  Cervical cancer is the fourth most common malignancy in females worldwide [1]. Amongst others, squamous cell carcinoma is the most prevalent histological subtype, which is very often associated with human papillomavirus (HPV) infection. On the other hand, endocervical adenocarcinomas (ECAs) comprise merely 25% of all primary cervical carcinomas [2]. Majority of the endocervical adenocarcinomas are HPV-related and harbor a strong association with high-risk genotypes of HPV. However, approximately 5.5 - 11% of all ECAs are reported to be HPV-negative and are, therefore, regarded as non-HPV-associated ECA. These non-HPV-driven subtypes of endocervical adenocarcinoma have distinct clinic-pathologic features and confer a poor prognosis [3]. Therefore, efforts were made to improve the classification of ECA and to establish clinically relevant and reproducible criteria for classifying cervical glandular malignancies.


  1. Arbyn M., et al. “Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis”. Lancet Global Health2 (2020): e191-e203.
  2. Kurman RJ., et al. “WHO classification of tumours of the female reproductive organs”. 4th edn. IARC, Lyon (2014).
  3. Xing B., et al. “Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review”. Frontiers in Oncology 10 (2021): 606335.
  4. Stolnicu S., et al. “International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix”. American Journal of Surgical Pathology2 (2018): 214-226.
  5. Stolnicu S., et al. “Recent advances in invasive adenocarcinoma of the cervix”. Virchows Archiv 5 (2019): 537-549.
  6. Hodgson A., et al. “International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility”. American Journal of Surgical Pathology 1 (2019): 75-83.
  7. Ren H., et al. “International Endocervical Adenocarcinoma Criteria and Classification (IECC): An Independent Cohort With Clinical and Molecular Findings”. International Journal of Gynecological Pathology (2021).


Citation: Nilay Nishith. “Endocervical Adenocarcinoma: A Paradigm Shift in Classification". Acta Scientific Women's Health 3.9 (2021): 38-39.


Copyright: © 2021 Nilay Nishith. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is May 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US