Nilay Nishith*

Senior Resident, Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

*Corresponding Author: Nilay Nishith, Senior Resident, Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Received: August 05, 2021; Published: August 19, 2021

  Cervical cancer is the fourth most common malignancy in females worldwide [1]. Amongst others, squamous cell carcinoma is the most prevalent histological subtype, which is very often associated with human papillomavirus (HPV) infection. On the other hand, endocervical adenocarcinomas (ECAs) comprise merely 25% of all primary cervical carcinomas [2]. Majority of the endocervical adenocarcinomas are HPV-related and harbor a strong association with high-risk genotypes of HPV. However, approximately 5.5 - 11% of all ECAs are reported to be HPV-negative and are, therefore, regarded as non-HPV-associated ECA. These non-HPV-driven subtypes of endocervical adenocarcinoma have distinct clinic-pathologic features and confer a poor prognosis [3]. Therefore, efforts were made to improve the classification of ECA and to establish clinically relevant and reproducible criteria for classifying cervical glandular malignancies.

References

1. Arbyn M., et al. “Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis”. Lancet Global Health2 (2020): e191-e203.
2. Kurman RJ., et al. “WHO classification of tumours of the female reproductive organs”. 4th edn. IARC, Lyon (2014).
3. Xing B., et al. “Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review”. Frontiers in Oncology 10 (2021): 606335.
4. Stolnicu S., et al. “International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix”. American Journal of Surgical Pathology2 (2018): 214-226.
5. Stolnicu S., et al. “Recent advances in invasive adenocarcinoma of the cervix”. Virchows Archiv 5 (2019): 537-549.
6. Hodgson A., et al. “International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility”. American Journal of Surgical Pathology 1 (2019): 75-83.
7. Ren H., et al. “International Endocervical Adenocarcinoma Criteria and Classification (IECC): An Independent Cohort With Clinical and Molecular Findings”. International Journal of Gynecological Pathology (2021).

Citation

Citation: Nilay Nishith. “Endocervical Adenocarcinoma: A Paradigm Shift in Classification". Acta Scientific Women's Health 3.9 (2021): 38-39.

Copyright

Copyright: © 2021 Nilay Nishith. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.