Rashmi Aggarwal1* and Pradeep Chugh2
1Department of Thyroid and Endocrine Research, Institute of Nuclear Medicine and Allied Sciences-INMAS, Delhi, India
2Department of Cardiology, Institute of Nuclear Medicine and Allied Sciences-INMAS, Delhi, India
*Corresponding Author: Rashmi Aggarwal, Department of Thyroid and Endocrine Research, Institute of Nuclear Medicine and Allied Sciences-INMAS, Delhi, India.
Received: July 20, 2021; Published: July 29, 2021
Hyperthyroidism is associated with increased morbidity and mortality from cardiovascular disease . Thyroid hormones significantly affect the cardiovascular systems. Both Heart and blood vessels are affected through genomic and non-genomic mechanisms. Tri iodothyronine (T3) the active thyroid hormone directly initiates the transcription of specific and non-specific genes acting on THR in the nucleus .
Non genomic effects of T3 are exerted on the plasma membrane, mitochondria and sarcoplasmic reticulum of cardiac myocytes.
Hyperthyroidism causes a spectrum of hemodynamic changes in the cardiovascular system like increase in heart rate, cardiac output, stroke volume, myocardial contractility and Left Ventricular mass . Atrial fibrillation is a common cardiac manifestation of hyperthyroidism. Even subclinical hyperthyroidism has been also associated with an increased risk of atrial fibrillation .
In patients with pre - existing heart disease, the hyperdynamic circulation accompanying hyperthyroidism will further impair cardiac function leading on to congestive cardiac failure, worsening angina, atrial fibrillation and thromboembolism .
Keywords: Hyperthyroidism; Heart Rate; Atrial Fibrillation
Citation: Rashmi Aggarwal and Pradeep Chugh. “Cardiovascular Manifestations of Hyperthyroidism". Acta Scientific Women's Health 3.8 (2021): 74-76.
Copyright: © 2021 Rashmi Aggarwal and Pradeep Chugh. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.