Victor Kravchenko*, Oleg Rakov, Olena Kovzun, Andriy Kovalenko and Viktoria Rakova
SI "VP Komissarenko State Institute of Endocrinology and Metabolism National Academy of Medical Sciences of Ukraine”, Ukraine
*Corresponding Author: Victor Kravchenko, Department of Epidemiology Endocrine Diseases, SI "VP Komissarenko State Institute of Endocrinology and Metabolism National Academy of Medical Sciences of Ukraine”, Ukraine.
Received: June 03, 2021; Published: July 29, 2021
Vitamin due to the presence of the receptor (VDR), which is found in almost all nuclear cells is an important regulator in the pathogenesis of many diseases. The question of the causal relationship between vitamin D deficiency and Graves 'disease and the importance of this vitamin for thyroid function in the treatment of Graves' disease deserves special attention. The aim of the study was to investigate the level of 25- (OH) D in the body in Graves' disease and its relationship with thyroid function. We examined 143 patients who were first diagnosed with moderate Graves' disease (GD). All patients studied by us, residents of Ukraine, 67% of them live in Kyiv, 19% in Kyiv region, 14% in other regions of Ukraine. The average age of the subjects was 43.8 ± 0.95, among whom were men 22.4%, women - 77.6%. The analysis of immune parameters and thyroid function depending on the age of patients, the content of vitamin D in the serum, and its quartile distribution before treatment. Subsequently, all patients were divided into two groups depending on the therapy. The first group included 73 subjects, whose average age was 44.69 ± 1.39, patients in this group received tyrosol at a dose of 5 - 10 mg per day. The second group consisted of 70 patients. whose average age was 42.93 ± 1.29, they took tyrosol at a dose of 5-10 mg per day and vitamin D preparations - 2000 MO/day. In patients with Graves' disease. the highest content of 25- (OH) D in serum was observed in the age group of 19-30 years -59.1 nmol/l and a low level of antibodies to the TSH receptor - 9.0 mUi/l. A significant decrease in the immune index was observed only in the 3rd and 4th quartiles, when the content of 25- (OH) D in the serum reached 47.5 nmol/l and above, i.e. approached a moderate deficit. At a slight increase to 34 nmol/l, such changes were insignificant. After 3 months of treatment, the level of AbrTSH in the serum during treatment with vitamin D was twice lower than when treated with tyrosol alone. After 6 months, compared with the treatment with tyrosol, the effect of treatment was 2 times better. In contrast to TPOAbs in Graves' disease without treatment with vitamin D, where it did not differ depending on the level of 25 (OH) D, in the second group after 6 months of treatment there was a significant decrease in this indicator (p = 0.009). Compared to tyrosol treatment alone, there was a significant increase in TSH levels and a decrease in thyroid volume after 6 months. Data on the dependence of thyroid function on the level of 25 (OH) D were indicative. In each of the quartiles, the level of TSH after treatment with vitamin D was 4-5 times higher than in the group of patients treated only with tyrosol. Convincing data on the positive effect of vitamin D on autoimmune parameters, thyroid function and the need for its inclusion in the treatment of Graves' disease.
Keywords: Thyroid, Graves' Disease, Tyrosol, Vitamin D, TSH, TSH Receptor, Antibodies to Thyroxine Peroxidase, Free Thyroxine, Free Triiodothyronine, Thyroid Volume, Risk Factors
Citation: Victor Kravchenko., et al. “Relationship Between Vitamin D and Autoimmune Condition and Thyroid Function with Newly Onset Grave’s Disease”. Acta Scientific Women's Health 3.8 (2021): 65-73.
Copyright: © 2021 Victor Kravchenko.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.