Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Research Article Volume 3 Issue 8

Effects of Intravenous Administration of Tranexamic Acid in Reducing Blood Loss during and After Caesarean Section

Anita Kant1*, Usha Priyambada Gupta2, Amrita Razdan Kaul3 and Shephali4

1Chairman, Department of Obstetrics and Gynaecology, Asian institute of Medical Sciences, Faridabad, Haryana, India
2Senior Consultant, Department of Obstetrics and Gynaecology, Asian institute of Medical Sciences, Faridabad, Haryana, India
3Consultant, Department of Obstetrics and Gynaecology, Asian Institute of Medical Sciences, Faridabad, Haryana, India
4DNB Resident, Final Year, Department of Obstetrics and Gynaecology, Asian institute of Medical Sciences, Faridabad, Haryana, India

*Corresponding Author: Anita Kant, Chairman, Department of Obstetrics and Gynaecology, Asian institute of Medical Sciences, Faridabad, Haryana, India.

Received: June 17, 2021; Published: July 09, 2021

Abstract

Objective: To study the safety and efficacy of Tranexamic acid (TXA) in reducing blood loss during and after the caesarean section.

Methodology: This is a randomized, case controlled, prospective open label trial conducted on ninety term pregnant females undergoing caesarean in our hospital for evaluating the blood loss with or without the use of TXA. Patients were randomly assigned to either cases (Receiving injection TXA) or controls (Not receiving TXA).

Results: Mean of total blood loss among cases was 267.27 ± 115.77 ml, while it was 428.13 ± 98.24 ml in controls (p value < 0.001). Its use was not associated with any side effect or complications like Thrombosis. Overall, the study supports the evidence of beneficial effects of TXA in significantly reducing blood loss during and after CS and hence reducing the need for blood transfusion.

Conclusion: TXA is effective in reducing blood loss during and after caesarean section.

Keywords: Bleeding; Caesarean Section; Postpartum; Tranexamic Acid

References

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  3. International Institute for Population Sciences (IIPS) and Ministry of Health and Family Welfare. National Family Health Survey-4 (NFHS-4), India-Factsheet.
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  10. Abdel-Aleem H., et al. “Effectiveness of Tranexamic acid on blood loss in patients undergoing elective cesarean section: randomized clinical trial”. Journal of Maternal-Fetal and Neonatal Medicine 26 (2013): 1705-1709.
  11. Lakshmi SJD and Abraham R. “Role of Prophylactic TXA in Reducing Blood Loss During Elective Cesarean Section”. Journal of Clinical and Diagnostic Research12 (2016): QC17-QC21.
  12. WOMAN Trial Collaborators. “Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial”. Lancet 389 (2017): 2105-2116.

Citation

Citation: Anita Kant., et al. “Effects of Intravenous Administration of Tranexamic Acid in Reducing Blood Loss during and After Caesarean Section”. Acta Scientific Women's Health 3.8 (2021): 11-15.

Copyright

Copyright: © 2021 Anita Kant.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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