Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Research Article Volume 3 Issue 7

Evaluation of Mutation in Oxytocin Receptor Gene in rs35062132 Variant in Women with a History of Preterm Delivery and Women without a History of Preterm Delivery

Zahra Zahiri1*, Fatemeh Zahiri2 and Bolhasan Rezaei3

1Master of Molecular Genetics, Iran
2M.S. Student in Field of Genetics, Iran
3Ph.D of Molecular Genetics, Iran

*Corresponding Author: Zahra Zahiri, Master of Molecular Genetics, Iran.

Received: May 03, 2021; Published: June 25, 2021

Abstract

Background and Objective: Oxytocin is a neuropeptide made in the ventral and supraoptical adjacent nuclei of hypothalamus. Oxytocin is a hormone regarded for activity of the neuropeptides establishing sexual behaviors, but, first of all, it is known for a role played in establishment of contraction of uterus while delivering.

Receptor of oxytocin is OXTR and availability of its receptor depends on the maternal serum level which increase of serum plays an important role in progression of pregnancy. This research aims to study a relationship between rs35062132 (R376G) polymorphism of OXTR gene and/with premature labor.

Studying Method: In this study conducted by case control method in 2018, 152 women divided into two groups of those with premature labor history (from 22 to 36 weeks who referred to the Shahid Rajaei hospital of Tonekabon) and those without premature labor history were studied. After collection of information using questionnaire, sampling and performance of the rest steps, study of polymorphism was carried out by PCR-sequencing technique, and results of sequencing determination were analyzed by the Chromas software.

Finding: Out of collection of 152 studied cases, there existed rs35062132 polymorphism of OXTR gene in 53 individuals (34.8%) while presenting results of their sequencing determination and 99individuals (65.1%) lacked this polymorphism.

Conclusion: Results of this research show that there is a relationship between rs35062132 polymorphism of OXTR gene with premature labor.

Keywords: Oxytocin; Premature Labor; Polymorphism; PCR-sequencing

References

  1. Leon Speroff and Marc A fritz. “Clinical Gynoncology, Endocrinology and infertility”. 7th ed., section 2.hormone Biosynthesis metabolism and mechanism of action, Philadelphia, PA (2005).
  2. Turner RA., et al. “Effects of emotion on oxytocin, prolactin, and ACTH in women”. Stress4 (2000): 269-276.
  3. Uvans-Moberg K. “Oxytocin may mediate the benefits of positive social interation and emotions”. Psychoneuroendocrinology 8 (1998): 819-835.
  4. Varma R and James D. “Antenatal care of women with previous preterm delivery current”. Obstetrics and Gynaecology 14 (2004): 207-215.
  5. Krymko H., et al. “Risk Factors for recurrent preterm delivery”. European Journal of Obstetrics and Gynecology and Reproductive Biology 113 (2004): 160-163.
  6. Dencker A., et al. “Early versus delayed oxytocin augmentation in nulliparous women with prolonged laboura randomised controlled trial”. British Journal of Obstetrics and Gynaecology 4 (2009): 530-536.
  7. Fraser W., et al. “Effects of early augmentation of labour with aminotomy and oxytocin in nulliparous women: a meta-analysis”. British Journal of Obstetrics and Gynaecology 2 (1998): 189-194.
  8. Marazziti D., et al. “A relationship between oxytocin and anxiety of romantic attachment”. Biomedical Central 2 (2006): 28.
  9. Berghella V., et al. “Patients with prior second-trimester Loss: prophylactic cerclage or serial transvaginal sonograms?” American Journal of Obstetrics and Gynaecology 187 (2002): 747-751.
  10. Bloom SL., et al. “Recurrence of preterm birth in singleton and twin pregnancies”. Obstetrics and Gynaecology 98 (2001): 379-385.
  11. Coomarasamy A., et al. “Aspirin for prevention of preeclampsia in women with historical risk factor: a systematic review”. Obstetrics and Gynaecology 101 (2003): 1319-1332.
  12. Eliyahu S., et al. “Epidemiologic risk factors for preterm delivery”. Israel Medical Association Journal2 (2002): 1115-1117.
  13. Demissie K., et al. “Trends in preterm birth and neonantal mortality among blacks and whites in the united states from 1989 to 1997”. American Journal of Epidemiology4 (2001): 307-315.
  14. Wei SQ., et al. “High-dose vs low-dose oxytocin for labor augmentation:a systematic review”. American Journal of Obstetrics and Gynaecology 4 (2010): 296-304.
  15. Ghanbarzadeh N., et al. “Comparison of the effect of oxcitoxin in induction of labor on the outcome of delivery”. Journal of Rafsanjan University of Medical Sciences6 (2013): 12-16.
  16. Jamal A and Kalantari R. “High and low dose oxytocin in augmentation of labor”. International Journal of Gynecology and Obstetrics 1 (2004): 6-8.
  17. Nachum Z., et al. “Comparsion between amniotomy, oxytocin or both for augmentation of labor in prolonged latent phase: a randomized controlled trial”. Reproductive Biology and Endocrinology 8 (2010): 136.
  18. Masoomi R., et al. “Role of oxytocin in anxiety in the normal parturition”. Tabibe-Shargh1 (2008): 53-58.
  19. K Lorenz., et al. “Commonoxytocin receptor gene polymorphisms and the risk for preterm birth”. Bos press and auden, Issn 07778.
  20. M AKerlund. “Vasopressin and oxytocin in normal reproduction and in the pathophysiology of preterm labour and primary dysmenorrhoea. Development of receptor antagonists for therapeutic use in these conditions”. Roczniki Akademii Medycznej w Bialymstoku 49 (2004): 18-21.
  21. G Gimpl and F Fahrenholz. “The oxytocin receptor system: structure, function, and regulation”. Physiology Review 81 (2001): 629-683.
  22. Y Kawamura., et al. “The association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments, as measured by TEMPS-A”. Journal of Affective Disorders 127 (2010): 31-37.
  23. S Wu., et al. “Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population”. Biological Psychiatry 58 (2005): 74-77.
  24. A R Fuchs., et al. “Oxytocin receptors and human parturition: A dual role for oxytocin in the intiation of labor”. Science 215 (1982): 1396-1398.
  25. M Johnson. Parturition, in Johnson and Everitt s essential reproduction 2007, Blackwell Publishing Co (2007): 245-254.
  26. M J Lucht., et al. “Associations between the oxytocin receptor gene (OXTR) and affect, Ioneliness and intelligence in normal subjects”. Progress in Neuro-Psychopharmacology and Biological Psychiatry 33 (2009): 860-866.
  27. SW Wen., et al. “Epidemiology of preterm birth and neonatal outcome”. Seminars in Fetal and Neonatal Medicine 9 (2004): 429-435.
  28. B Clausson., et al. “Genetic influence on birth-weight and gestational length determined by studies in off-spring of twins”. BJOG 107 (2000): 375-381.
  29. K Hao., et al. “A candidate gene association study on preterm delivery: application of high throughput genotyping technology and advanced statistical methods”. Human Molecular Genetics 13 (2004): 683-691.
  30. Z A Kistka., et al. “Heritability of parturition timing: An extended twin design analysis”. American Journal of Obstetrics and Gynaecology 199 (2008): 43 el-45.
  31. T F Porter., et al. “The risk of preterm birth across generations”. Obstetrics and Gynaecology 90 (1977): 63-67.
  32. K Ward., et al. “The heritability of preterm delivery”. Obstetrics and Gynaecology 106 (2005): 1235-1239.
  33. Lorenez Kussel., et al. “Common oxytocin receptor gene polymorphisms and the risk for preterm birth”. Disease Marks 34 (2013): 51-56.
  34. Thorburn G D and JRG Challis. “Endocrine control of parturition”. Physiology Review 59 (1979): 863-917.
  35. Fuchs AR., et al. “Correlation between oxytocin receptor concentration and responsiveness of oxytocin in pregnant rat myometrium: effects of ovarian steroid”. Endocrinology 113 (1983): 742-749.
  36. Garfield RE., et al. “Hormonal control of gap junctions in sheep mymotrium”. Biology of Reproduction 21 (1979): 999-1007.
  37. Fuchs A R. “Oxytocin in animal parturition”. In Oxytocin: Clinical and Laboratory Studies. J. A. Amico and A. G.Robinson, editors. Elsevier, Amsterdam (1985): 207-235.
  38. Chan W Y. “Enhanced prostaglandin synthesis in the parturient rat uterus and its effects on myometrial oxytocin receptor concentrations”. Prostaglandins 34 (1987): 889-902.
  39. Dawood M Y., et al. “Oxytocin in maternal circulation and amniotic fluid during pregnancy”. The Journal of Clinical Endocrinology and Metabolism 49 (1979): 429-434.
  40. Leak RD., et al. “Plasma oxytocin concentrations in men, nonpregnant women and pregnant women before and during spontaneous labor”. The Journal of Clinical Endocrinology and Metabolism 53 (1981): 730-733.
  41. Amico JA., et al. “Studies of oxytocin in plasma of women during hypocontractile labor”. The Journal of Clinical Endocrinology and Metabolism 58 (1984): 274-279.
  42. Chard T. “Fetal and maternal oxytocin in human parturition”. American Journal of Perinatology 6 (1989): 145-152.

Citation

Citation: Zahra Zahiri., et al. “Evaluation of Mutation in Oxytocin Receptor Gene in rs35062132 Variant in Women with a History of Preterm Delivery and Women without a History of Preterm Delivery”. Acta Scientific Women's Health 3.7 (2021): 15-21.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US