Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)
Volume 3 Issue 6
Oncological and Reproductive Outcome in Epithelial Ovarian Cancer in Women
Less than 30 Years of Age
Binamra Sigdel1*, Chitrathara Keshav2, Sanam Puzhakkal3, VP Gangadharan4, Suresh Kayastha1, Remi Abdul Shukur1, Anupana S1 and Tony Augustine1
1Fellow, Department of Surgical and Gynecological Oncology, VPS Lakeshore Hospital, Kochi, Kerala, India 2Consultant, Department of Surgical and Gynecological Oncology, VPS Lakeshore Hospital, Kochi, Kerala, India 3Associate Consultant, Department of Surgical and Gynecological Oncology, VPS Lakeshore Hospital, Kochi, Kerala, India 4Consultant, Department of Medical Oncology, VPS Lakeshore Hospital, Kochi, Kerala, India
*Corresponding Author: Binamra Sigdel, Fellow, Department of Surgical and Gynecological Oncology, VPS Lakeshore Hospital, Kochi, Kerala, India.
Objective: The objective of this study is to evaluate oncological and reproductive outcome of epithelial ovarian cancers and its clinicopathological patterns in patients less than 30 years of age.
Methods: This is a retrospective, single center study and all the patients diagnosed with EOCs from 2014 to 2019 AD who underwent either primary surgery or completion surgery in this center were included in the study. Thirty-six patients with EOCs were identified and their clinicopathological characteristics, overall survival, progression free survival and reproductive outcomes were determined. Mean was used to describe continuous variables whereas frequency and percentages were used to describe categorical variables.
Results: The number of Epithelial Ovarian Cancers in women less than 30 years was 36 (8.07%). The mean age of the patients was 24. The most common mode of presentation was abdominal pain in cases followed by abdominal distension. The most common tumor subtypes were mucinous carcinoma followed by eight cases each of borderline serous and serous carcinoma. Most of the patients presented in early stage of disease. Twenty-two patients (61.12%) underwent fertility sparing surgery. Five patients had recurrence and there was one mortality. The median follow up period was 44 (14 - 90) months. Progression free survival was 37.41 months and overall survival was 44 months. The overall survival rate was 94.45%.
Conclusion: EOCs are rare in young patient and diagnosed at early stage. They have excellent prognosis with fertility sparing surgery and adjuvant chemotherapy and successful pregnancy can be achieved in most of the cases.
Keywords: Age Less Than Thirty Years; Malignant Epithelial Ovarian Cancer; Reproductive Outcome; Survival Outcome; Recurrence
Berek JS and Bast RC Jr. “Epithelial ovarian cancer”. In: Kufe DW, Pollock RE, Weichselbaum RR et al.,editors. Holland-Frei Cancer Medicine. 6th ed. Hamilton (ON): BC Decker (2003).
Chen LM and Berek JS. “Ovarian and fallopian tubes”. In: Haskell CM, editor. Cancer treatment. 5th ed. Philadelphia, PA: WB Saunders (2000): 55.