Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Review Article Volume 3 Issue 6

Endometriosis and Oral Health: An Unsolved Mystery

Swati Jain1* and Kirti Jain2

1Consultant, Mobile Dental Clinic Project, Maulana Azad Institute of Dental Sciences, Delhi, India
2Consultant, Obstetrician and Gynecologist, Ashok Multispeciality Hospital, Delhi, India

*Corresponding Author: Swati Jain, Consultant, Mobile Dental Clinic Project, Maulana Azad Institute of Dental Sciences, Delhi, India.

Received: April 27, 2021; Published: May 14, 2021


Endometriosis is a pathological entity characterized by abnormal growth of endometrial tissue in ectopic sites which induces a chronic inflammatory reaction, scar tissue and adhesions that may distort a woman’s pelvic anatomy. The signs and symptoms of the disease may be contributed to the generalized inflammatory response of the disease. In women with endometriosis, the peritoneal fluid is becomes dynamic with the increased number of activated macrophages and important differences in the cytokine/chemokine profile. Keeping in mind the inflammatory milieu which endometriosis creates; it would be interesting to analyze its effect on similar health conditions affecting the other parts of the body as well including mouth. Oral health is a key indicator of overall health, well-being and quality of life. Periodontal disease is a chronic inflammatory disease of periodontium and is characterized by periodontal ligament loss and destruction of surrounding alveolar bone. It is the main cause of tooth loss. The present article reviews the possible mechanism of association between Endometriosis and Oral Health. The literature search reveals three possible mechanisms include Oxidative Stress and Increased Reactive Oxygen Species (Ros) Production, Global Immune Dysregulation and Hormonal dysregulation. Endometriosis still remains a mystery to most of the gynaecologists throughout the world. It would be interesting to understand in detail whether an etio-pathogenic link exists between endometriosis and oral health. Further, population based longitudinal studies are required to assess the possible link to ensure comprehensive treatment for the patients suffering from endometriosis. Multidisciplinary approach is the key.


Keywords: Endometriosis; Infertility; Population; Pain; Oral Health


  1. Giudice LC and Kao LC. “Endometriosis”. Lancet 364 (2004): 1789-1799.
  2. Chaichian S. “It Is the Time to Treat Endometriosis Based on Pathophysiology”. Journal of Reproduction and Infertility 1 (2019): 1-2.
  3. Parasar P., et al. “Endometriosis: Epidemiology, Diagnosis and Clinical Management”. Current Obstetrics and Gynecology Reports 1 (2017): 34-41.
  4. Eisenberg VH., et al. “Epidemiology of endometriosis: a large population‐based database study from a healthcare provider with 2 million members”. British Journal of Obstetrics and Gynaecology 1 (2019): 55-62.
  5. Umelo Chijioke and Manchanda Rahul. “Trends in Endometriosis among Laparoscopic Patients in Multiple Hospitals in Northern India: A 3-Year Review”. Journal of SAFOG 7 (2015): 167-170.
  6. Overton C and Park C. “Endometriosis: more on the missed disease”. BMJ 341 (2010): c3727.
  7. Facchin F., et al. “Personality in women with endometriosis: Temperament and character dimensions and pelvic pain”. Human Reproduction 31 (2016): 1515-1521.
  8. Berek JS. “Berek and Novak’s Gynecology”. 15th edition. Lippincott Williams and Wilkins, North American Edition edition (2012).
  9. Sampson JA. “Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity”. American Journal of Obstetrics and Gynecology 14 (1927): 442-469.
  10. Rana N., et al. “Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis”. Fertility and Sterility 65 (1996): 925-930.
  12. Nasir M A. “Prevalence of periodontal disease, its association with systemic diseases and prevention”. International Journal of Health Sciences (Qassim) 11.2 (2017): 72-80.
  13. Shaju JP., et al. “Prevalence of periodontitis in the Indian population: A literature review”. Journal of Indian Society of Periodontology 1 (2011): 29-34.
  14. Thomas V., et al. “Towards a Common Etiopathogenesis: Periodontal Disease and Endometriosis”. Journal of Human Reproductive Sciences 3 (2018): 269-273.
  15. Kavoussi SK., et al. “Periodontal disease and endometriosis: analysis of the National Health and Nutrition Examination Survey”. Fertility and Sterility2 (2009): 335-342.


Citation: Swati Jain and Kirti Jain. “Endometriosis and Oral Health: An Unsolved Mystery". Acta Scientific Women's Health 3.6 (2021): 43-45.


Copyright: © 2021 Swati Jain and Kirti Jain. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US