Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Research Article Volume 2 Issue 11

The Possible Association of Female Pattern Hair Loss and Alteration in Serum Cholecalciferol Level

Mohammed S Al-Abadie1, Hussain Tukmatchy2, Ari Ahmad3, Anandadeep Mandal4, Patrick A Ball5 and Hana Morrissey6*

1Consultant Dermatologist, Department of Dermatology, Royal Wolverhampton Hospital Trust, Wolverhampton, United Kingdom
2General Practice Clinical Lead, Henley Primary Care Centre, United Kingdom
3Department of Dermatology, Royal Wolverhampton Hospital Trust, Wolverhampton, United Kingdom
4Assistant Professor, Statistician, Birmingham Business School, University of Birmingham, United Kingdom
5Professor of Pharmacy, School of Pharmacy, University of Wolverhampton, United Kingdom
6Reader in Clinical Pharmacy, School of Pharmacy, University of Wolverhampton, United Kingdom

*Corresponding Author: Hana Morrissey, Reader in Clinical Pharmacy, School of Pharmacy, Faculty of Science and Engineering, University of Wolverhampton, City Campus, United Kingdom.

Received: October 06, 2020; Published: November 28, 2020



Background: Vitamin D has a central role in neuronal, reproductive, autoimmune, infectious, and heart diseases. Female Pattern Hair Loss (FPHL) is described as a non-scarring, progressive thinning of the hair resulting from a decreasing ratio of terminal hairs to thinner vellus hairs.

Aim: To explore the possibility of vitamin D deficiency contribution to hair loss in women in the local population in West Midlands England.

Method: Records of women from different age groups who were treated in the dermatology outpatient clinic for any skin conditions and had their vitamin D status assessed as part of their usual care. In this study we also examine the impact of vitamin D levels and age on hair loss.

Results: The studies reviewed medical records of 48 patients diagnosed with dermatological conditions. Low levels of vitamin D significantly affects the loss of hair (p = 0.046). The odds ratio estimated is 3.545. Our results show that the impact of low vitamin D level is significantly prevalent for the age groups 35 - 45 and moderately impacted age group 55 - 65 years.

Conclusion: Vitamin D has a significant role in hair-loss process, and possibly early correction may have a role in prevention and treatment in women aged 35 - 45 year of age.

Keywords: Female Pattern Hair Loss; FPHL; Vitamin D; Pre-menopausal women; Post-Menopausal Women; Baldness



  1. Kechichian E and Ezzedine K. “Vitamin D and the skin: An update for dermatologists”. American Journal of Clinical Dermatology2 (2018): 223-235.
  2. Chen TC., et al. “Factors that influence the cutaneous synthesis and dietary sources of vitamin D”. Archives of Biochemistry and Biophysics 2 (2007): 213-217.
  3. Tripkovic L., et al. “Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: A systematic review and meta-analysis”. The American Journal of Clinical Nutrition 6 (2012): 1357-1364.
  4. Lucas RM., et al. “Vitamin D and immunity”. F1000 Prime Reports 6 (2014): 118.
  5. Messenger AG and Sinclair R. “Follicular miniaturization in female pattern hair loss: Clinicopathological correlations”. British Journal of Dermatology 5 (2006): 926-930.
  6. Vujovic A and Del Marmol V. “The female pattern hair loss: Review of etiopathogenesis and diagnosis”. BioMed Research International (2014): 767628.
  7. Yip L., et al. “Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss: An update of what we now know”. Australasian Journal of Dermatology 2 (2011): 81-88.
  8. Norwood OT. “Incidence of female androgenetic alopecia (female pattern alopecia)”. Dermatologic Surgery 1 (2001): 53-54.
  9. Paik J., et al. “The prevalence and types of androgenetic alopecia in Korean men and women”. British Journal of Dermatology 1 (2001): 95-99.
  10. Wang TL., et al. “Prevalence of androgenetic alopecia in china: A community-based study in six cities”. British Journal of Dermatology 4 (2010): 843-847.
  11. Hamilton JB. “The relationship between common baldness and male sex hormones”. Transactions of the New York Academy of Sciences (1946).
  12. Whiting DA. “Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss”. Journal of the American Academy of Dermatology 3 (2001): 81.
  13. Vexiau P., et al. “Role of androgens in female-pattern androgenetic alopecia, either alone or associated with other symptoms of hyperandrogenism”. Archives of Dermatological Research 12 (2000): 598-604.
  14. Price VH. “Androgenetic alopecia in women”. Journal of Investigative Dermatology Symposium Proceedings 1 (2003): 24-27.
  15. Lips P. “Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications”. Endocrine Reviews 4 (2001): 477-501.
  16. El-Mongy N., et al. “Serum 25-hydroxy vitamin D3 level in Egyptian patients with alopecia areata”. Journal of the Egyptian Women’s Dermatologic Society1 (2013).
  17. Moneib H., et al. “Possible association of female-pattern hair loss with alteration in serum 25-hydroxyvitamin D levels”. Egyptian Journal of Dermatology and Venerology 1 (2014): 15-20.
  18. Rasheed H., et al. “Serum ferritin and vitamin D in female hair loss: Do they play a role?” SPP2 (2013): 101-107.
  19. Banihashemi M., et al. “Serum vitamin D3 level in patients with female pattern hair loss”. International Journal of Trichology3 (2016): 116-120.
  20. Fawzi MMT., et al. “Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia”. Journal of Cosmetic Dermatology 4 (2016): 318-323.
  21. Hayes CE., et al. “The immunological functions of the vitamin D endocrine system”. Molecular and Cellular Biology 2 (2003): 277-300.
  22. Cash TF., et al. “Psychological effects of androgenetic alopecia on women: Comparisons with balding men and with female control subjects”. Journal of the American Academy of Dermatology 4 (1993): 568-575.
  23. Maxwell JD. “Seasonal variation in vitamin D”. Proceedings of the Nutrition Society 3 (1994): 533-543.
  24. Demay MB. “The hair cycle and vitamin D receptor”. Archives of Biochemistry and Biophysics 1 (2012): 19-21.


Citation: Hana Morrissey., et al. “The Possible Association of Female Pattern Hair Loss and Alteration in Serum Cholecalciferol Level”.Acta Scientific Women's Health 2.12 (2020): 28-33.


Acceptance rate35%
Acceptance to publication20-30 days

Indexed In

News and Events

Contact US