Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Research Article Volume 2 Issue 11

Prevalence of TORCH Infections during Pregnancy: A Prospective Cohort Study in Tribal Region of Gujarat, India

Magdalena Stefanowicz-Rutkowska*, Wojciech Matuszewski and Elżbieta Bandurska-Stankiewicz

Clinical Department of Endocrinology, Diabetology and Internal Diseases, Faculty of Medical Sciences, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Poland

*Corresponding Author: Magdalena Stefanowicz-Rutkowska, Doctor, Clinical Department of Endocrinology, Diabetology and Internal Diseases, Faculty of Medical Sciences, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Poland.

Received: October 03, 2020; Published: November 18, 2020

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Abstract

Objectives: Our aim was to identify the correlation between autoimmune thyroid diseases (AITD) and the prevalent of diabetic retinopathy (DR) in women with diabetes mellitus type 1 (DM1).

Methods: We reviewed medical records adults women with type 1 diabetes diagnosed on the basis of WHO criteria - lasting at least a year and with AITD for at least a year. The control group consisted of women without AITD, selected according to age, BMI, DM1 duration and metabolic control. Anthropometric parameters, parameters of diabetes metabolic control, thyroid and metabolic status and presence of DR were assessed. Logistic regression analysis was used to assess the relationship between AITD and prevalent DR.

Results: We included 122 women with type 1 diabetes aged 36 ± 13 years. The average duration of DM1 was comparable between the groups, in the study group was 12 ± 10 years, and in the control group 13 ± 9 years. The parameters of metabolic control of DM as HbA1c percentage, the lipid profile and blood pressure did not differ significantly between the study groups. Patients from the study group had significantly higher concentration of TSH, fT4, anti-TPO and anti-Tg than the control group.

Conclusion: After excluding the recognized risk factors for DR in women with DM1 and concomitant AITD, showed a significantly lower chance of developing non-proliferative DR, therefore in this group of patients it is recommended to have standard assessment of TSH and thyroid antibodies levels for the early diagnosis of AITD and possible levothyroxine treatment.

Keywords: Diabetes Type 1; Women; Autoimmune Thyroid Disease; Diabetic Retinopathy; Hashimoto’s Thyroiditis; Graves-Basedow’ Disease

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References

  1. American Diabetes Association. “Diagnosis and Classification of Diabetes Mellitus”. Diabetes Care1 (2019): S13-S28.
  2. International Diabetes Federation. Diabetes Atlas 8th Edition (2017).
  3. Olivares AM., et al. “Animal Models of Diabetic Retinopathy”. Current Diabetic Report 17 (2017): 93.
  4. Hainsworth DP., et al. “Risk Factors for Retinopathy in Type 1 Diabetes: The DCCT/EDIC Study”. Diabetes Care5 (2017): 875-882.
  5. Corriere M., et al. “Epidemiology of diabetes and diabetes complications in the elderly: an emerging public health burden”. Current Diabetic Report6 (2013): 805-813.
  6. Harjutsalo V., et al. “Sex-related differences in the longterm risk of microvascular complications by age at onset of type 1 diabetes”. Diabetologia 54 (2011): 1992-1999.
  7. Bolon B. “Cellular and molecular mechanisms of autoimmune disease”. Toxicologic Pathology2 (2012): 216-229.
  8. Desai MK and Brinton RD. “Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan”. Frontiers in Endocrinology 10 (2019): 265.
  9. Sang YW and Kyung CH. “Recent Advances in Autoimmune Thyroid Diseases”. Endocrinology and Metabolism 31 (2016): 379-385.
  10. Chiovato L., et al. “Hypothyroidism in Context: Where We’ve Been and Where We’re Going”. Advances in Therapy 36 (2019): 47-58.
  11. Sfriso P., et al. “Infections and autoimmunity: the multifaceted relationship”. Journal of Leukocyte Biology 3 (2010): 385-395.
  12. Wu L., et al. “Classification of diabetic retinopathy and diabetic macular edema”. World Journal of Diabetes6 (2013): 290-294.
  13. Amoaku WM., et al. “Diabetic retinopathy and diabetic macular oedema pathways and management: UK Consensus Working Group”. Eye 34 (2020): 1-51.
  14. Czech A and Tatoń J Cukrzyca. Katowice: Wyd. Elamed (2009).
  15. Kański JJ. “Choroby siatkówki pochodzenia naczyniowego”. W: Zagórski Z. (red.). Okulistyka kliniczna. Wrocław: Wyd. Medyczne Urban and Partner (1997): 344-379.
  16. Schreur V., et al. “Risk factors for development and progression of diabetic retinopathy in Dutch patients with type 1 diabetes mellitus”. Acta Ophthalmology5 (2018): 459-64.
  17. Perros P., et al. “Frequency of thyroid dysfunction in diabetic patients: value of annual screening”. Diabetic Medicine7 (1995): 622-627.
  18. Stefanowicz-Rutkowska MM., et al. “Autoimmune Thyroid Disease is Associated with a Lower Prevalence of Diabetic Retinopathy in Patients with Type 1 Diabetic Mellitus”. Medicina (Kaunas)6 (2020): 255.
  19. Goldner WS., et al. “Cyclic changes in glycemia assessed by continuous glucose monitoring system during multiple complete menstrual cycles in women with type 1 diabetes”. Diabetes Technology and Therapeutics 6 (2004): 473-480.
  20. Barrett-Connor E. “The Rancho Bernardo Study: 40 years studying why women have less heart disease than men and how diabetes modifies women’s usual cardiac protection”. Global Heart2 (2013).
  21. Crandall CJ and Barrett-Connor E. “Endogenous sex steroid levels and cardiovascular disease in relation to the menopause: a systematic review”. Endocrinology and Metabolism Clinics of North America 42 (2013): 227-253.
  22. Dorman JS., et al. “Menopause in type 1 diabetic women: is it premature?” Diabetes 50 (2001): 1857-1862.
  23. Salonia A., et al. “Sexual function and endocrine profile in fertile women with type 1 diabetes”. Diabetes Care 29 (2006): 312-316.
  24. Kallen AN and Pal L. “Cardiovascular disease and ovarian function”. Current Opinion in Obstetrics and Gynecology 23 (2011): 258-267.
  25. Sowers M., et al. “Insulin resistance, hemostatic factors, and hormone interactions in preand perimenopausal women: SWAN”. Journal of Clinical Endocrinology and Metabolism 88 (2003): 4904- 4910.
  26. Morrison JL., et al. “Diabetic retinopathy in pregnancy: a review”. Clinical Experiment Ophthalmology 44 (2016): 321-334.
  27. Guiducci S., et al. “Vascular complications of scleroderma”. Autoimmune Review7 (2007): 520-523.
  28. Guiducci S., et al. “Mechanisms of vascular damage in SSc — implications for vascular treatment strategies”. Rheumatology 5 (2008): v18-v20.
  29. Ozawa GY., et al. “Male-Female Differences in Diabetic Retinopathy?” Current Eye Research 40 (2015): 234-246.
  30. Tomczyńska M., et al. “Autoimmunizacyjne choroby tarczycy jako czynnik ryzyka chorób układu sercowo-naczyniowego”. Choroby Serca i Naczyń1 (2017): 30-38.
  31. Zhang X., et al. “Correlation between thyroid autoantibodies and intracranial arterial stenosis in stroke patients with hyperthyroidism”. Journal of Neurology Science 318 (2012): 82-84.
  32. Chutia H., et al. “Evaluation of thyroid function in type 2 diabetes in north-eastern part of India: A hospital-based study”. Journal of Family Medicine and Primary Care 4 (2018): 752-755.
  33. Rodacki M., et al. “Should thyroid-stimulating hormone goals be reviewed in patients with Type 1 diabetes mellitus? Results from The Brazilian Type 1 Diabetes Study Group”. Diabetic Medicine12 (2014): 1665-1672.
  34. Rogowicz-Frontczak A., et al. “Patients with diabetes type 1 and thyroid autoimmunity have low prevalence of microangiopathic complications”. Endocrine1 (2015): 185-188.
  35. Meyer MR and Barton M. “Estrogens and coronary artery disease: new clinical perspectives”. Advances in Pharmacology 77 (2016): 307-360.
  36. Wells CC., et al. “Diabetic nephropathy is associated with decreased circulating estradiol levels and imbalance in the expression of renal estrogen receptors”. Gender Medicine 2 (2005): 227-237.
  37. Madej A., et al. “Prevalence of thyroid autoantibodies and thyroid dysfunction in adults with type 1 diabetes”. Diabetologia Praktyczna6 (2011): 223-228.
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Citation

Citation: Magdalena Stefanowicz-Rutkowska., et al. “Autoimmune Thyroid Disease in Women with Type 1 Diabetes is Associated with a Lower Incidence of Diabetic Retinopathy". Acta Scientific Women's Health 2.12 (2020): 21-27.




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