Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Review Article Volume 2 Issue 11

Duration of the effect of fertility and insulin resistance on IVF or ICSI results in women with PCOS

Mustafa Zakaria1*, Mohamed Zarqaoui2, Noureddine Louanjli3, Nisrine En-naciri4, Mohamed Ennaji5, Amal Kabit6, Naima El-yousfi7 and Romaissa Boutiche8

1Reproductive Biology, and Assisted Reproductive Technology, Consultant at IRIFIV Fertility Center, Administrative Deputy and Writer for the ART IRIFIV Scientific Research Group (AISRG) Casablanca, Morocco
2Endoscopic Surgery Obstetrics and Gynecology FR, Coordinator of IRIFIV Fertility Center, Head of the ART IRIFIV Scientific Research Group (AISRG) Casablanca, Morocco
3Department of Clinical Biology, / Head of LABOMAC Laboratory of Clinical Analysis and Assisted Reproductive Technology IRIFIV Fertility Center, ANFA Fertility Center - Executive Vice President of the ART IRIFIV Scientific Research Group (AISRG) Casablanca, Morocco
4Biology, Senior Clinical Embryologist, Laboratory IVF Agadir, Souss-Massa, Member of the Scientific Research Group and Researcher in the Scientific Research Group, Agadir, Morocco
5Senior Clinical Embryologist at IRIFIV Fertility Center, Member of the Scientific Research Group and Researcher in the Scientific Research Group, Casablanca, Morocco
6Senior Clinical Embryologist at IRIFIV Fertility Center, Member of the Scientific Research Group and Researcher in the Scientific Research Group, Casablanca, Morocco
7Senior Clinical Embryologist at Ibn Badis Fertility Center, Member of the Scientific Research Group and researcher in the Scientific Research Group, El Jadida, Morocco
8Clinical Embryologist, Laboratory IVF Algeria, Rotaby Fertility Center Algiera - Algiers, Member of the Scientific Research Group and researcher in the Scientific Research Group, Algeria

*Corresponding Author: Mustafa Zakaria, Reproductive Biology, and Assisted Reproductive Technology, Consultant at IRIFIV Fertility Center, Administrative Deputy and Writer for the ART IRIFIV Scientific Research Group (AISRG) Casablanca, Morocco.

Received: October 03, 2020; Published: October 30, 2020

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Abstract

  The main effects of insulin resistance in the pathogenesis of PCOS, strategies to reduce insulin and improve reproductive parameters in PCOS patients and should be recommended for all overweight and obese patients, and the effects of insulin resistance on the results of IVF or sperm injection were examined. Intracytoplasmic (ICSI) in women with PCOS. Insulin sensitivity was measured by continuous glucose infusion with a form evaluation test (CIGMA). Insulin-resistant (n = 26) and non-insulin-resistant (n = 30) women with PCOS underwent a total of 100 cycles of long-term down-regulation with poserilin acetate, stimulation with recombinant human FSH, and IVF or ICSI. And the ovarian stimulation period for hormone tests. The insulin-resistant and non-insulin-resistant women had similar concentrations of FSH, LH, testosterone, and androstenedione during stimulation, but the insulin-resistant women had hyperinsulinemia and low concentrations of globulin associated with sex hormones. The insulin-resistant women also had low concentrations of estradiol during stimulation and required higher FSH doses, but these differences disappeared after controlling for higher body weight in the insulin-resistant group of women. Insulin resistance was neither associated with hormone levels nor with IVF outcomes. Obesity, regardless of insulin resistance, is associated with relative gonadal resistance, necessary to confirm these findings. In conclusion, it has been shown that reducing insulin resistance improves the ovulation rate in PCOS patients, but there is strong evidence to maintain the usefulness of insulin-causing drugs as a treatment option.

Keywords: Insulin Resistance and PCOS; Obesity and Insulin Resistance; Normal Insulin Sensitivity; Ovarian Stimulation and IVF; Stimulating Hormone and Tests; PCOS; Insulin Sensitivity Recombinant Follicle; Obesity is Associated with Limited Ovulation; AMH in Obese Patients

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Citation

Citation: Mustafa Zakaria., et al. “Duration of the effect of fertility and insulin resistance on IVF or ICSI results in women with PCOS". Acta Scientific Women's Health 2.11 (2020): 55-62.




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Acceptance rate35%
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Impact Factor0.742

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