Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Research Article Volume 2 Issue 5

Effect of Data Selection on Reimbursement Decisions. Breast Cancer Case

Abdalla Abotaleb*

WHO Project Manager, Health Care Reforming Expert, Egypt

*Corresponding Author:Abdalla Abotaleb, WHO Project Manager, Health Care Reforming Expert, Egypt.

Received: March 04, 2020; Published: May 04, 2020

×

Abstract

 One of the daily challenges for health care policy makers is selecting the right patient for the right treatment with affordable price. If we taking breast cancer treatments at law middle income country, as Egypt's experience with breast cancer, an incidence (15.4) per 100,000 beside the prevalence of HER2-positive breast cancer is approximately 15% to 20% of primary breast cancers. this will lead to economic burden as well as consequences on decision makers. When they decides to treat with monoclonal antibodies like Trastuzumab what is the appropriate time to treat the patient to achieve the efficient management of resources 6 months versus 12 months of adjuvant Trastuzumab in early breast cancer. What will be the best option for the resources and patients outcomes? To answer the previous question an economic study was conducted trying to support decisions makers. The result of economic model showed that selecting one clinical study for deciding shorter time regimen versus standard regimen is might not be strong evidence for taking the decisions because the economic model was so sensitive to the following parameters. Selecting data for health care decision making in oncology should take in consideration. Strength of evidence sensitivity analysis of that data should be conducted to ensure effective health care decisions and losing the previous criteria might lead to negative impact on patients’ outcomes and treatment resources.

Keywords: Trastuzumab 6 Months; Health Policy; Reimbursement

×

References

  1. Piccart-Gebhart MJ., et al. “Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer”. New England Journal of Medicine 16 (2005): 1659-1672.
  2. Romond EH., et al. “Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer”. New England Journal of Medicine 16 (2005): 1673-1684.
  3. Slamon D., et al. “Adjuvant trastuzumab in HER2-positive breast cancer”. New England Journal of Medicine 14 (2011): 1273-1283.
  4. Joensuu H., et al. “Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer”. New England Journal of Medicine 8 (2006): 809-820.
  5. European Medicines Agency. “Committee for medicinal products for human use (CHMP) guideline on the choice of the non-inferiority margin”. Statistics in Medicine 10 (2006): 1628-1638.
  6. Smith I., et al. “2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial”. Lancet 9555 (2007): 29-36.
  7. Herceptin European Summary of product characteristics (2013).
  8. Perez EA., et al. “Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31”. Journal of Clinical Oncology 25 (2011): 3366-3373.
  9. Gianni L., et al. “Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial”. Lancet Oncology3 (2011): 236-244.
  10. Spielmann M., et al. “Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trial”. Journal of Clinical Oncology 36 (2009): 6129-6134.
  11. Perez EA., et al. “Sequential versus concurrent trastuzumab in adjuvant chemotherapy for breast cancer”. Journal of Clinical Oncology 34 (2011): 4491-4497.
  12. Goldhirsch A., et al. “HERA trial: 2 year versus 1 year of trastuzumab after adjuvant chemotherapy in women with HER2-positive early breast cancer at 8 years of median follow up. San Antonio Breast Cancer Symposium 2012”. Cancer Research 24 (2012): abstract S5-2.
  13. Piaggio G., et al. “Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement”. Journal of the American Medical Association 10 (2006): 1152-1160.
×

Citation

Citation: Abdalla Abotaleb. “Effect of Data Selection on Reimbursement Decisions. Breast Cancer Case”. Acta Scientific Women's Health 2.5 (2020): 23-27.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US