Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Research Article Volume 2 Issue 5

Effect of Endosulfan Toxicity on 1st Stage of Spermiogenesis Leading to Infertility

Asiya Nisa1, Yashowardhan Suman1, Mehjabeen1 and Suhail Jeelani Shah2*

1Department of Biotechnology, B.N College, Patna University, Patna, Bihar, India
2Vector Control Research Centre (ICMR), India

*Corresponding Author: Suhail Jeelani Shah, Vector Control Research Centre (ICMR), India.

Received: February 24, 2020; Published: April 24, 2020

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Abstract

 Toxicities of organochlorine pesticides like Endosulfan show adverse effects on many organs and organ systems like liver, kidney, testes, muscles, immune system and hematological system. Most of the previous studies focused on effects of organochlorine on activity of spermatogenic cells. However, there is very little research reporting effects of endosulfan on spermiogenesis till date. Therefore, the current study was aimed to assess the effect of Endosulfan on spermiogenesis in the testes of mice model. A 5 mg/gm body wt. Endosulfan was administered to mice by oral gavage method. Normally in the beginning of spermiogenesis, the sperm head gets embedded in the sertoli cell and finally released from the seminiferous tubules. It is very significant to note that the testes in endosulfan treated mice. They were found to get affected at an early stage (from spermatids to 1st stage of spermiogenesis), as compared to any other organochlorine pesticide. The present study also confirms that only oral administration (5 mg/gm body wt.) for 20 days shows effect on spermiogenesis in 30% of mice. Furthermore, in 20 days treated mice, notable changes were seen during the 1st stage of spermiogenesis. Significant decrease in testosterone level (P ≤ 0.0001) and sperm count (P ≤ 0.001) was observed after endosulfan exposure. Abnormal spermatozoa in the lumen of seminiferous tubules were found to be very few in number and with a non-motile tail. Approximately 30% of the heads of spermatozoa were found with rounded acrosome, which will lead to infertility.

Keywords: Endosulfan; Toxicity; Spermiogenesis; Infertility; Mice

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References

  1. Amizadeh M and Askari saryazdi G. “Effect of Endosulfan on human health”. Toxicology12 (2016): WM002617.
  2. Benjamin Cummings. “Human Anatomy and Physiology”. 5th San Francisco. Ref Type: Generic; humananotomyphys00mari (2001).
  3. Yoshinaga K and Toshimori K. “Organization and modifications of sperm acrosomal molecules during spermatogenesis and epididymal maturation”. Microscopy Research and Technique 61 (2003): 39‐45.
  4. Olson GE and Winfrey VP. “Structure of acrosomal matrix domains of rabbit sperm”. Journal of Structural Biology 112 (2003): 41-48.
  5. Ito Toshimori., et al. “Lack of acrosome formation in mice lacking a Golgi protein, GOPC”. Proceedings of the National Academy of Sciences of the United States of America 99 (2002): 11211‐11216.
  6. Khan PK and Sinha SP. “Ameliorating effects of vitamins c on murine sperm toxicity induced by three pesticides (endosulfan, phosphamidonand mancozeb)”. Mutagenesis1 (1996): 33-36.
  7. A Nath., et al. “Endosulfan induced oxidative stress and biochemical changes in testes of mice”. European Journal of Pharmaceutical and Medical Research9 (2016): 600- 603.
  8. Liza O Donnell. “Mechanism of Spermiogenesis and Spermiation how they are disturbed”.”. Spermiogenesis 4 (2014): e979623-e97911.
  9. Hack R., et al. “Chronic toxicity and carcinogenetical studies with the insecticides endosulfan in rats and mice”. Food and Chemical Toxicology 33 (1995): 941-950.
  10. N Sinha R., et al. “Effect of Endosulfan on the testes of growing rats”. Veterinary and Human Toxicology 37 (1996): 547-549.
  11. Singh SK and Pandey RS. "Gonadal toxicity of short term chronic endosulfan exposure to male mice”. Indian Journal of Experimental Biology 27 (1989): 341-346.
  12. Chitra KC., et al. “Chronic effect endosulfan on the testicular functions of mice”. Asian Journal of Research and Reports in Endocrinology4 (1999)- 203-206.
  13. Sakkas D., et al. “Origin of DNA damage in ejaculated human spermatozoa”. Reviews of Reproduction 4 (1998a): 31-37.
  14. Lifeng T., et al. “Effects of fenvalerate exposure on semen quality among occupational workers”. Contraception 73 (2006): 92-96.
  15. Lenda D and Rizzi R. “Study of reproductive function in persons occupationally exposed to 2,4-dichlorophenoxyacetic acid (2,4-D)”. Mutation Research 262 (1991): 47-50.
  16. Xia S., et al. “Genotoxic affect in spermatozoa of carbaryl- exposed workers”. Toxicological Sciences 85 (2005): 615-623.
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Citation

Citation: Suhail Jeelani Shah., et al. “Effect of Endosulfan Toxicity on 1st Stage of Spermiogenesis Leading to Infertility". Acta Scientific Women's Health 2.5 (2020): 10-14.




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