Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Case Report Volume 2 Issue 2

Successful Live Birth in a Couple with Poor Ovarian Reserve and Severe Teratozoospermia (Acephalic Spermatozoa Syndrome) with ICSI and MACS Technique

Mona Shroff*, Akshay Jani, Chaitali Patel and Mamta Jani

Nova IVF Fertility, Surat, Gujarat, India

*Corresponding Author: Mona Shroff, Nova IVF Fertility, Surat, Gujarat, India.

Received: December 02, 2019; Published: January 10, 2020



  We report a case of primary infertility with successful pregnancy outcome in a couple with poor ovarian reserve and severe teratozoospermia (acephalic spermatozoa syndrome).

  Couple presented with primary infertility of 12 years’ duration. Evaluation of female partner revealed poor ovarian reserve with AFC of 2/3 and AMH of 1.4 ng/mL. Semen analysis revealed 100% morphologically abnormal sperms with 99% pinhead sperms. In spite of counselling for poor prognosis, couple wanted to go for ICSI with self sperms. Patient was stimulated as per antagonist protocol -5 oocytes were retrieved, out of which 4 were metaphase II. Semen sample revealed 99% pinhead sperms with very few bent neck sperms. Density gradient (DG) was carried out followed by Magnetic Activated Cell Sorting (MACS) on post DG semen sample. ICSI was done with bent neck sperms with normal head. 3 oocytes were fertilized (Fertilization rate was 75%). Two cleavage stage embryos were transferred resulting in singleton pregnancy with successful live birth at full term.

  Pinhead sperm is a variant of microcephalic sperm with no or minimal DNA content. Even in cases of acephalic sperm syndrome, a good fertilization rate and successful pregnancy outcome can be achieved by isolating sperms with abnormally implanted head and using MACS to separate DNA fragmented apoptotic sperms from healthy sperms. Very few successful cases has been reported in literature and this could be the first to use MACS.

Keywords: Acephalic Spermatozoa; Genetic Origin; Infertility; Pin Heads; Sperm Pathology; MACS; Teratozoospermia; ICSI; Diminished Ovarian Reserve



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Citation: Mona Shroff., et al. “Successful Live Birth in a Couple with Poor Ovarian Reserve and Severe Teratozoospermia (Acephalic Spermatozoa Syndrome) with ICSI and MACS Technique”. Acta Scientific Women's Health 2.2 (2020): 38-41.


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