Abstract

Objectives:Obesity is a worldwide health concern linked with high morbidity and mortality. Therapeutic strategies such as surgical operation and synthetic drugs ultimately cause high costs and serious complications. The anti-obese effect of dietary fiber is usually accepted to reduce body weight gain. Gum Arabic (GA) Acacia senegal used as a dietary fiber to reduce body weight.

Aim: The aim was to study the effects of GA on visceral adipose tissue (VAT) and its relation with hypothalamic expression of energy homeostasis related genes. We offered GA to 90 days old female mice in drinking water (10% w/v) for 84 days. Food consumption, body weight, plasma glucose, plasma lipid profile, plasma leptin, PYY and GLP-1 and mRNA of pro-opiomelanocortin (POMC) were measured. GA in drinking water significantly (P<0.05) decreased food intake associated with reduction of body weight and VAT accumulation compared to control. In addition, GA significantly (P<0.05) decreased plasma glucose, plasma total cholesterol, LDL and VLDL whereas increased HDL compared to control. The treatment of GA significantly increased plasma PYY and GLP-1 concentration whereas decreased leptin concentrations compared to the control. Moreover, GA significantly increased hypothalamic expression of POMC mRNA. However, GA treatment did not alter plasma triglycerides.

Conclusion: We conclude that GA decreases food intake, reduces body weight, as well as plasma lipids associated with reduction of VAT. GA also increases plasma PYY and GLP-1 concentration and on hypothalamic expression of POMC mRNA.

KeywordsGum Arabic; Pro-Opiomelanocortin; Hypothalamus; Mice

References

1. Morton GJ., et al. “Central nervous system control of food intake and body weight”. Nature7109 (2006): 289-295.
2. Sallis JF and Hinckson EA. “Reversing the obesity epidemic in young people: building up the physical activity side of energy balance”. Lancet Diabetes Endocrinol3 (2014): 190-191.
3. Speakman JR. “Body size, energy metabolism and lifespan”. Journal of Experimental Biology9 (2005): 1717-1730.
4. Rosen Evan D., et al. “Adipocytes as regulators of energy balance and glucose homeostasis”. Nature7121 (2006): 847-853.
5. Avena NM and Bocarsly ME. “Dysregulation of brain reward systems in eating disorders: neurochemical information from animal models of binge eating, bulimia nervosa, and anorexia nervosa”. Neuropharmacology1 (2012): 87-96.
6. Mercer RE., et al. “The role of NPY in hypothalamic mediated food intake”. Frontiers in Neuroendocrinology4 (2011): 398-415.
7. Bi S., et al. “Dorsomedial hypothalamic NPY and energy balance control”. Neuropeptides6 (2012): 309-314.
8. Patterson Christa M., et al. “Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction”. Molecular Metabolism1–2 (2012): 61-69.
9. Zhang W., et al. “Hypothalamus-adipose tissue crosstalk: neuropeptide Y and the regulation of energy metabolism”. Nutrition and Metabolism (Lond) 11 (2014): 27.
10. Koch M and Horvath TL. “Molecular and cellular regulation of hypothalamic melanocortin neurons controlling food intake and energy metabolism”. Molecular Psychiatry7 (2014): 752-761.
11. Oyama LM., et al. “The role of anorexigenic and orexigenic neuropeptides and peripheral signals on quartiles of weight loss in obese adolescents”. Neuropeptides6 (2010): 467-474.
12. , et al. “The Role of “mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa”. International Journal of Endocrinology 21 (2013): 483145.
13. Martin-Fardon R and Boutrel B. “Orexin/hypocretin (Orx/Hcrt) transmission and drug-seeking behavior: is the paraventricular nucleus of the thalamus (PVT) part of the drug seeking circuitry?”. Frontiers in Behavioral Neuroscience 6 (2012): 75.
14. Ilnytska O., et al. “Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite”. Diabetes1 (2011): 97-106.
15. Richard D., et al. “The corticotropin-releasing hormone system in the regulation of energy balance in obesity”. International journal of obesity and related metabolic disorders2 (2000): S36-39.
16. Wardlaw SL. “Hypothalamic proopiomelanocortin processing and the regulation of energy balance”. European Journal of Pharmacology1 (2011): 213-219.
17. Hayes MR., et al. “Role of the glucagon-like-peptide-1 receptor in the control of energy balance”. Physiology and Behavior5 (2010): 503-510.
18. Pimentel GD., et al. “The role of neuronal AMPK as a mediator of nutritional regulation of food intake and energy homeostasis”. Metabolism2 (2013): 171-178.
19. Wardle J., et al. “Obesity associated genetic variation in FTO is associated with diminished satiety”. The Journal of Clinical Endocrinology and Metabolism9 (2008): 3640-3643.
20. , et al. “Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats”. PLoS One 5.1 (2010): e8771.
21. Conde-Sieira M., et al. “Effect of different glycaemic conditions on gene expression of neuropeptides involved in control of food intake in rainbow trout; interaction with stress”. Journal of Experimental Biology 213 (2010): 3858-3865.
22. Martinez de Morentin PB., et al. “Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase”. Diabetes4 (2012) 807-817.
23. Ilnytska O and Argyropoulos G. “The role of the Agouti-Related Protein in energy balance regulation”. Cellular and Molecular Life Sciences17 (2008): 2721-2731.
24. Tyler V., et al. “Pharmacognosy. Philadelphia”. Lea and Febiger (1977): 64-68.
25. Ali BH., et al. “Biological effects of gum arabic: a review of some recent research”. Food Chem Toxicology1 (2009): 1-8.
26. Slavin J. “Why whole grains are protective: biological mechanisms”. Proceedings of the Nutrition Society1 (2003): 129-134.
27. Chandalia M., et al. “Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus”. The New England Journal of Medicine19 (2000): 1392-1398.
28. Woods SC. “Metabolic signals and food intake. Forty years of progress”. Appetite 71 (2013): 440-444.
29. Del Prete., et al. “The role of gut hormones in controlling the food intake. What is their role in emerging diseases?”. Endocrinología y Nutrición (English Edition), 59.3 (2012): 197-206.
30. Musa Hassan H., et al. “Gum arabic down-regulate PPAR-γ and SCD mRNA expression in mice”. Polish Annals of Medicine1 (2015): 11-17.
31. Ahmed Abdelkareem A., et al. “Gum arabic decreased visceral adipose tissue associated with downregulation of 11β-hydroxysteroid dehydrogenase type I in liver and muscle of mice”. Bioactive Carbohydrates and Dietary Fibre1 (2015): 31-36.
32. Ahmed Abdelkareem A., et al. “Corticosterone in ovo modifies aggressive behaviors and reproductive performances through alterations of the hypothalamic-pituitary-gonadal axis in the chicken”. Animal Reproduction Science3 (2014): 193-201.
33. Livak KJ and Schmittgen TD. “Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method”. Methods4 (2001): 402-408.
34. De Pergola., et al. “Obesity as a Major Risk Factor for Cancer”. Journal of Obesity (2013): 11.
35. Scaglione R., et al. “Hypoadiponectinemia: a link between visceral obesity and metabolic syndrome”. Journal of Diabetes and Endocrinology 1 (2010): 27-35.
36. , et al. “Effect of long term ingestion of gum arabic on the adipose tissues of female mice”. Food Hydrocolloids 25.5 (2011): 1344-1349.
37. Schneeman BO. “Dietary fiber: comments on interpreting recent research”. Journal of the American Dietetic Association9 (1987): 1163.
38. Brownlee IA., et al. “Alginate as a Source of Dietary Fiber”. Critical Reviews in Food Science and Nutrition6 (2005): 497-510.
39. Kelley JJ and Tsai AC. “Effect of pectin, gum arabic and agar on cholesterol absorption, synthesis, and turnover in rats”. The Journal of Nutrition4 (1978): 630-639.
40. Sharma RD. “Hypocholesterolaemic effect of gum acacia in men”. Nutrition Research (1985): 1321-1326.
41. Moundras C., et al. “Fermentable polysaccharides that enhance fecal bile acid excretion lower plasma cholesterol and apolipoprotein E-rich HDL in rats”. The Journal of Nutrition11 (1994): 2179-2188.
42. Gallaher DD., et al. “Viscosity and fermentability as attributes of dietary fiber responsible for the hypocholesterolemic effect in hamsters”. Journal of Nutrition2 (1993): 244-252.
43. Evans AJ., et al. “Relationship between structure and function of dietary fibre: a comparative study of the effects of three galactomannans on cholesterol metabolism in the rat”. British Journal of Nutrition1 (1992): 217-229.
44. Eastwood MA. “The Physiological Effect of Dietary Fiber: An Update”. Annual Review of Nutrition 12 (1992): 19-35.
45. Sanchez D., et al. “Dietary fiber, gut peptides, and adipocytokines”. Journal of Medicinal Food 3 (2012): 223-230.
46. Adam CL., et al. “Different types of soluble fermentable dietary fibre decrease food intake, body weight gain and adiposity in young adult male rats”. Nutrition and Metabolism (Lond) 36 (2014).
47. Islam A., et al. “Viscous dietary fiber reduces adiposity and plasma leptin and increases muscle expression of fat oxidation genes in rats”. Obesity (Silver Spring)2 (2012): 349-355.
48. Keenan MJ., et al. “Effects of resistant starch, a non-digestible fermentable fiber, on reducing body fat”. Obesity (Silver Spring)9 (2006): 1523-1534.
49. Phillips RJ and Powley TL. “Tension and stretch receptors in gastrointestinal smooth muscle: re-evaluating vagal mechanoreceptor electrophysiology”. Brain Research Reviews1-2 (2000): 1-26.
50. Isaksson H., et al. “High-fiber rye diet increases ileal excretion of energy and macronutrients compared with low-fiber wheat diet independent of meal frequency in ileostomy subjects”. Food and Nutrition Research 12 (2013): 57.

Citation

Citation: Abdelkareem A Ahmed., et al. "Gum Arabic Increases Hypothalamic POMC mRNA Expression Associated with Decreased Plasma Lipids Profile in Mice".Acta Scientific Women's Health 2.1 (2020): 08-14.

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Copyright: © 2020 Abdelkareem A Ahmed., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.