Acta Scientific Ophthalmology (ISSN: 2582-3191)

Research Article Volume 8 Issue 5

Does Triamcinolone Improve Outcomes in Vitrectomy for Open-Globe Trauma? A Systematic Review and Meta-Analysis

Ali Alseneid* and Alhassen Alseneid

University of Buckingham Medical School/Milton Keynes University Hospital, United Kingdom

*Corresponding Author: Ali Alseneid, University of Buckingham Medical School/Milton Keynes University Hospital, United Kingdom

Received: April 16, 2025; Published: April 28, 2025

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Abstract

Background:Open-globe trauma is a significant cause of vision loss, often necessitating pars plana vitrectomy. However, postoperative complications, particularly proliferative vitreoretinopathy (PVR), limit visual recovery and anatomical success. This systematic review and meta-analysis evaluate the efficacy of intraoperative triamcinolone acetonide as an adjunct to vitrectomy in improving surgical outcomes in open-globe trauma.

Methods:

A comprehensive literature search was conducted across PubMed, Embase, and Cochrane Central to identify randomized controlled trials (RCTs) comparing intraoperative triamcinolone with standard vitrectomy in patients undergoing surgery for open-globe injury. Data from three eligible RCTs (n = 388 participants, 367 eyes) were synthesized using random- and fixed-effects models. Primary outcomes included visual acuity improvement (≥10 ETDRS letters), retinal reattachment rates, and PVR incidence. Risk of bias was assessed using the Cochrane RoB 2 tool.

Results:

Triamcinolone use was associated with a statistically significant improvement in visual acuity (RR = 1.10; 95% CI: 1.04-1.16; p = 0.0165) and a modest enhancement in retinal reattachment (RR = 1.07; 95% CI: 1.03-1.11; p = 0.0165). Additionally, PVR incidence was reduced (RR = 0.92; 95% CI: 0.85-0.99; p = 0.0354), suggesting a possible mild protective effect. Across all outcomes, interstudy heterogeneity was negligible (I² = 0%), and visual assessment of funnel plots did not indicate publication bias. Adverse events were infrequent and comparable between groups, with transient intraocular pressure elevations resolving without intervention.

Conclusion:

Intraoperative triamcinolone acetonide demonstrates a favorable safety profile and may provide modest benefits in visual recovery, anatomical success, and PVR prevention following vitrectomy for open-globe trauma. While these findings are statistically significant, their relevance should be interpreted with caution due to limited evidence base. Additional larger-scale trial would increase the clarity of long-term efficacy and optimize usage protocols.

Keywords: Open-globe Trauma; Triamcinolone Acetonide; Pars Plana Vitrectomy; Proliferative Vitreoretinopathy; Retinal Reattachment

References

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Citation

Citation: Ali Alseneid and Alhassen Alseneid. “Does Triamcinolone Improve Outcomes in Vitrectomy for Open-Globe Trauma? A Systematic Review and Meta-Analysis".Acta Scientific Ophthalmology 8.5 (2025): 18-28.

Copyright

Copyright: © 2025 Ali Alseneid and Alhassen Alseneid. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

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