Rashida Riaz¹, Maira Sharafat², Misra Anjum³, Salyha Ilyas⁴, Maleeha Qalab⁵ and Samia Iqbal⁶

¹Consultant Ophthalmologist DHQ Kasur, Pakistan
²Consultant Optometrist, The University of Faisalabad, Pakistan
³Senior Optometrist in Sardar Yasin Malik Hospital Clinical Incharge in Haji Murad Trust Eye Hospital Gujranwala
⁴Optometrist, Sardar Yasin Malik Hospital Gujranwala, Pakistan
⁵Optometrist Tree Tops Wapda Town Lahore, Pakistan
⁶Lecturer Faculty of Medicine and Allied Health Sciences IUB Bahawalpur, Pakistan

*Corresponding Author: Samia Iqbal, Lecturer Faculty of Medicine and Allied Health Sciences IUB Bahawalpur, Pakistan.

Received: June 19, 2023; Published: March 05, 2025

Abstract

Introduction: To assess the number of corneal endothelial cells in retinal detachment patients following silicone oil removal.

Study Design: Randomized control study.

Place of Study: Eye Unit-II, Ophthalmology Department, Mayo Hospital, Lahore.

Duration of Study: 1st May 2022 to January 2023.

Material and Methods: A total of 54 patients with retinal detachment were chosen from the Ophthalmology Department of Mayo Hospital Lahore. The group was divided into groups A and B. There were 27 patients in Category A who were pseudophakic in the affected eye, and 27 patients in Category B who were phakic in the affected eye. Patients with a history of eye surgery other than a cataract operation, any retinal disorder, or a corneal disorder diagnosed with tractional retinal detachment were excluded from the study. For the purpose of removing silicone oil, all patients underwent a 23 gauge pars planavitrectomy. All patients have bilateral specular microscopy performed for endothelial cell count, coefficient of variation, and proportion of hexagonal cells both preoperatively and four months after surgery. Following specular microscopy, results were recorded.

Results: The study included 54 patients, of which 29 were men and 25 were women. The patients' average age was 53.45 5.41. Ages ranged from 36 to 63 in category B and from 38 to 64 in category A. The mean preoperative count in the operated eye in category A was 2344.58 ± 62.48, whereas the mean preoperative count in category B was 2472.08 ± 41.67. While group B's mean post-operative count in the operated eye was 2444.09 ± 39.41, category A's mean post-operative endothelial count in the operated eye was 2267.05 ± 76.81. It was statistically significant that the endothelial cell count had decreased.. Endothelial cell counts in both groups dropped, with cell losses of 31.49 ± 26.79 in the group of phakic patients and 78.63 42.05 in the group of pseudophakic patients.

Conclusion: After the silicon oil was removed, the endothelial cell count fell in both categories, with cell losses of 31.49 ± 26.79 in the group of phakic patients and 78.63 ± 42.05 in the group of pseudophakic patients. Endothelial count loss that is statistically significant was observed.

Keywords: Corneal Endothelial Cell Count; Retinal Detachment; Specular Microscope; Phakic; Pseudophakic

References

1. Mentes R and Stellmans P. “Comparison of post-operative comfort in 20 gauge Versus 23 gauge pars planavitrectomy”. Bulletin de la Societe Belge d'Ophtalmologie 311 (2009): 5-10.
2. Kim MJ., et al. “The safety and efficacy of transconjunctivalsutureless 23 gauge vitrectomy”. Korean Journal of Ophthalmology 4 (2007): 201-207.
3. Suzuki S., et al. “Corneal thickness measurements: Scanningslit corneal topography and non contact specular microscopy versus ultrasonic Pachymetry”. Journal of Cataract and Refractive Surgery7 (2003): 1313-1318.
4. Mccarey BC., et al. “Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices and new intra ocular drugs and solutions”. Cornea 1 (2008): 1-16.
5. Islam QU., et al. “Age related changes in corneal morphological characteristics of healthy Pakistani eyes”. Saudi Journal of Ophthalmology 2 (2017): 86-90.
6. Ang M., et al. “Endothelial cell loss and graft survival after Descemet’s stripping automated endothelial Keratoplasty and penetrating keratoplasty”. Ophthalmology 11 (2012): 2239-2244.
7. Hasegava Y., et al. “Risk factors for corneal endothelial cell loss by cataract surgery in eyes with pseudoexfoliation syndrome”. Clinical Ophthalmology 10 (2016): 1685-1689.
8. Mamalis N., et al. “Toxic anterior segment syndrome”. Journal of Cataract and Refractive Surgery2 (2009): 324-333.
9. Watanabe A., et al. “Changes in corneal thickness after vitreous surgery”. Clinical Ophthalmology 6 (2016): 1293-1296.
10. Marco TG., et al. “Corneal complications during and after vitrectomy for retinal detachment in photorefractive keratectomy treated eyes”. Medicine 50 (2015): 2215.
11. Yanyelli A., et al. “Primary 23 gauge vitreoretinal surgery for rhegmatogenous retinal detachment”. Indian Journal of Ophthalmology 2 (2012): 226-230.
12. Baillif S and Gastaud P. “Complications of silicon oil tamponade”. Journal Francais d'Ophtalmologie 3 (2014): 259-265.
13. Zafar S., et al. “Comparison of 1000-centistoke versus 5000-centistoke silicone oil in complex retinal detachment surgery”. Journal of College of Physicians and Surgeons Pakistan1 (2016): 36-40.
14. Ellen LH., et al. “Results and complications of temporary silicone oil tamponade in patients with complicated retinal detachments”. Retina2 (2001): 107-114.
15. Gupta OP., et al. “Short-term outcomes of 23-gauge pars planavitrectomy”. American Journal of Ophthalmology2 (2008): 193-197.
16. Wimpissinger B., et al. “23-gauge versus 20- gauge system for pars planavitrectomy: a prospective randomized controlled trial”. British Journal of Ophthalmology11 (2008): 1483-1487.
17. Recchia FM., et al. “Small-gauge pars planavitrectomy”. Ophthalmology 9 (2010): 1851-1857.
18. Goyal JI., et al. “Corneal endothelial changes following pars planalensectomy”. Indian Journal of Ophthalmology 39 (1990): 25-27.
19. Setala K., et al. “Changes in corneal endothelium after treatment of retinal detachment with intraocular silicone oil”. Acta Ophthalmologica 1 (1989): 37-43.
20. Goezinne F., et al. “Corneal endothelial cell density after vitrectomy with silicone oil for complex retinal detachments”. Retina2 (2014): 228-236.

Citation

Citation: Samia Iqbal., et al. “Change in Endothelial Cell Count after Silicon Oil Removal in Phakic and Pseudophakic Patients After Retinal Detachment".Acta Scientific Ophthalmology 8.3 (2025): 24-27.

Copyright

Copyright: © 2025 Samia Iqbal., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.