Sudama Kharbind¹*, Namrata Pandey² and Hari Bahadur Thapa²

¹Bachelor of Optometry and Vision Science, National Academy of Medical Science, Nepal
²Paediatric, Strabismus and Neuro-ophthalmology Department, Lumbini Eye Institute and Research Center, Nepal

*Corresponding Author: Sudama Kharbind, Bachelor of Optometry and Vision Science, National Academy of Medical Science, Nepal.

Received: February 24, 2025; Published: February 28, 2025

Abstract

Marfan’s syndrome is among the most common inherited connective tissue disorders with significant ocular manifestation. It is usually associated with a mutation in the FBN1 gene located at the 15q15-21 band, which makes the fibrillin-1 protein. It can affect several body systems, including skeletal, ocular, cardiovascular, and pulmonary systems, as well as the dura, skin, and integument. It affects all sexes and ethnicities equally. Fibrillin-1 provides structural support in most of the ocular structures. A mutation or other abnormalities of the fibrillin-1 protein result in zonule weakening, which allows subluxation or even dislocation of the lens. The ocular finding of Marfan’s syndrome is only ectopic lentis (as a major) and myopia greater than 3 D (as a minor) included in the Ghent-2 criteria. In contrast, the other features of Marfan’s syndrome (transillumination defect, abnormal flat cornea, increased axial length, corneal astigmatism, and retinal detachment) are not included in the Ghent-2 nosology. Refractive error is one of the common causes of visual impairment in Marfan’s syndrome patients; however, the best approach for visual rehabilitation is still controversial. Proper refractive correction and visual rehabilitation, especially in children, pose significant challenges for the optometrist and pediatric ophthalmologist due to ongoing visual development and difficulty explaining their visual problems. Proper refractive correction with glasses and/or special contact lenses is the initial approach in mild cases of ectopic lentis. Early surgical intervention should be considered in advanced cases where conservative management fails to correct the refractive error or prevent functional amblyopia.

Keywords: Amblyopia; Conservative Management; Marfan’s Syndrome; Refractive Challenges

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Citation

Citation: Sudama Kharbind., et al. “Refractive Challenges in Marfan's Syndrome: A Review of Non-Surgical Management Strategies".Acta Scientific Ophthalmology 8.3 (2025): 02-08.

Copyright

Copyright: © 2025 Sudama Kharbind., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.