Tangil Ahmed¹, Abir Bin Sajj²*, Shammi Islam Toma³, Tohura Sharmin⁴ and Abrar Ahmed¹

¹Department of Retina, Vision Eye Hospital, Dhaka, Bangladesh
²Department of Cornea and Refractive Surgery, Vision Eye Hospital, Dhaka, Bangladesh
³Department of Glaucoma, Vision Eye Hospital, Dhaka, Bangladesh
⁴Department of Community medicine, Ad-Din Women’s Medical College, Dhaka, Bangladesh

*Corresponding Author: Abir Bin Sajj, Department of Cornea and Refractive Surgery, Vision Eye Hospital, Dhaka, Bangladesh.

Received: February 13, 2024; Published: April 02, 2024

Abstract

Purpose: To evaluate the association of serum homocysteine level with retinal vein occlusion.

Methods: This cross-sectional study was conducted in the Department of Ophthalmology, BSMMU, Dhaka from March 2017 to August 2019. After informed consent, a total of 46 subjects were selected with age ranging from 35-75 years. Among them, 23 subjects with RVO were considered as the study group and 23 aged and sex matched subjects without RVO was considered as control group for comparison. The study parameters were serum homocysteine level, folate and vitamin B12 were estimated in the Department of Biochemistry, BSMMU, Dhaka. Unpaired Students “t” test, Chi Square test, Pearson’s correlation coefficient (r) test and Logistic regression analysis were done as applicable. p value < 0.05 was accepted as level of significance.

Results: In this study, mean plasma homocysteine level was 23.75 ± 6.21 μmol/L and 9.29 ± 3.19 μmol/L, serum folate level was 3.67 ± 0.96ng/ml and 10.49 ± 3.67 ng/ml and serum vitamin B12 level was 376.09 ± 176.07 pg/ml and 540.26 ± 300.57 pg/ml respectively in study and control groups. Logistic regression model demonstrated that hyperhomocysteinemia was about 6 times (OR = 5.655; 95% CI = 2.279 to 14.032) more chance to develop RVO than the subjects of normal plasma homocysteine level. Serum homocysteine level showed negative correlation with serum folate and vitamin B12 levels in RVO patients which was statistically significant (< 0.001).

Conclusion: It can be concluded that serum Homocysteine level was significantly increased in RVO patients.

Keywords: RVO; Homocysteine; Folate; Vitamin B12

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Citation

Citation: Abir Bin Sajj., et al. “Association of Serum Homocysteine Level with Retinal Vein Occlusion: A Comparative Cross-Sectional Study".Acta Scientific Ophthalmology 7.5 (2024): 03-08.

Copyright

Copyright: © 2024 Abir Bin Sajj., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.