Marcelo Oliveira Coutinho¹, Paloma Nicolau Tomaz¹, Denismar Borges de Miranda²*, Brenda Cavalieri Jayme¹ and Fabíola Duque Friedman³

¹Resident Physician in Ophthalmology at Hospital de Base do Distrito Federal, Brasilia, Federal District, Brazil
²Resident Physician in Ophthalmology at Hospital de Base do Distrito Federal, PhD in Tropical Medicine and Public Health UFG, Brasilia, Federal District, Brazil
³Optometrist, Department of Ophthalmology, Mediclinic Airport Road Hospital, Abu Dhabi, UAE
⁴Optometrist, Department of Ophthalmology, Mediclinic Airport Road Hospital, Abu Dhabi, UAE

*Corresponding Author: Denismar Borges de Miranda, Resident Physician in Ophthalmology at Hospital de Base do Distrito Federal, PhD in Tropical Medicine and Public Health UFG, Brasilia, Federal District, Brazil.

Received: July 03, 2023; Published: August 02, 2023

Abstract

Purpose: To report two clinical cases of a patient with Wolfram Syndrome.

Case Reports: Case 1, 22 years old, female, manifested by onset in childhood of diabetes mellitus (4 years old), low visual acuity (LVA) at 14 years old, and central diabetes insipidus (17 years old) and later bilateral sensorineural deafness and neurological disorders. Case 2, 23 years old, female, at 5 years of age, she starts with diabetes mellitus, LVA (17 years old) evolving later with bilateral sensorineural deafness. Both cases present biomicroscopy and applanation tonometry within normal limits; the visual field examination reveals, in both cases, absolute scotoma with a small central island of vision.

Conclusion: The essential features for the diagnosis are the presence of early-onset diabetes mellitus and optic atrophy. These two reported cases draw attention to the professional's expertise in establishing the association between their main characteristics, favoring early clinical diagnosis, thus enabling better multidisciplinary follow-up.

 Keywords: Wolfram syndrome; Optic atrophy; Diabetes mellitus; Visual acuity.

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Citation

Citation: Denismar Borges de Miranda., et al. “Wolfram Syndrome: The Importance of a Multisystemic Approach in Early Diagnosis".Acta Scientific Ophthalmology 6.9 (2023): 07-10.

Copyright

Copyright: © 2023 Denismar Borges de Miranda., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.