Acta Scientific Ophthalmology (ISSN: 2582-3191)

Short Communication Volume 5 Issue 10

Tests to Diagnose Ocular Myasthenia Gravis

Madhuvanthi Mohan, Sashwanthi Mohan*, Sujatha Mohan and Mohan Rajan

Rajan Eye Care Hospital, Chennai, Tamilnadu, India

*Corresponding Author: Sashwanthi Mohan, Rajan Eye Care Hospital, Chennai, Tamilnadu, India.

Received: August 08, 2022; Published: September 07, 2022

  • Myasthenia gravis is an autoimmune, neuromuscular junction disorder causing fatiguability and weakness of the muscles [1].
  • Ocular myasthenia gravis (OMG) is where weakness is isolated to the periocular muscles, namely, extraocular muscles, levator palpebrae superioris and orbicularis oculi [2].
  • Extraocular muscles (EOMs) are more commonly affected as they contain twitch fibers.
  • These twitch fibres develop tension faster and have a higher frequency of synaptic firing than limb muscles.
  • They are more susceptible to fatigue.
  • Tonic muscle fibers are needed to maintain the gaze in any direction.
  • This type of fiber has fewer acetyl choline receptors, making them prone to receptor loss and damage [3].
  • Ptosis and diplopia are usually the presenting signs in these patients [4].
  • There is a stronger predilection in males [2,3].


  1. Nair AG., et al. “Ocular myasthenia gravis: a review”. Indian Journal of Ophthalmology10 (2014): 985-991.
  2. Grigg J. “Extraocular muscles: Relationship of structure and function to disease”. Australian and New Zealand Journal of Ophthalmology 27 (1999): 369‐370.
  3. Sommer N., et al. “Ocular myasthenia gravis. A critical review of clinical and pathophysiological aspects”. Documenta Ophthalmologica 84 (1993): 309-333.
  4. Grob D., et al. “The course of myasthenia gravis and therapies affecting outcome”. Annals of the New York Academy of Sciences 505 (1987): 472-499.
  5. Sethi KD., et al. “Ice pack test for myasthenia gravis”. Neurology 37 (1987): 1383-1395.
  6. Juel VC and Massey JM. “Myasthenia gravis”. Orphanet Journal of Rare Diseases 2 (2007): 44.
  7. Costa J., et al. “Repetitive nerve stimulation in myasthenia gravis - relative sensitivity of different muscles”. Clinical Neurophysiology 115 (2004): 2776-2782.
  8. Chen CS., et al. “Double vision in a patient with thyroid disease: What’s the big deal?” Survey on Ophthalmology 52 (2007): 434‐439.
  9. Osserman KE., et al. “Myasthenia gravis and thyroid disease: Clinical and immunologic correlation”. J Mount Sinai Hospital N Y 34 (1967): 469‐83.


Citation: Sashwanthi Mohan., et al. “Tests to Diagnose Ocular Myasthenia Gravis".Acta Scientific Ophthalmology 5.10 (2022): 06-07.


Copyright: © 2022 Sashwanthi Mohan., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

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