Electrophysiological Study After Levodopa in Amblyopic Eyes
Mona Abdelkader*, Sameh Saleh and Ayman Fawzy
Department of Ophthalmology, Faculty of Medicine, Mansoura University, Egypt
*Corresponding Author: Mona Abdelkader, Department of Ophthalmology, Faculty of Medicine, Mansoura University, Egypt.
August 01, 2022; Published: August 24, 2022
Purpose: To study the clinical and electrophysiological changes after Levodopa in amblyopic eyes.
Methods: Fifty patients with amblyopia (20 hypermetropic anisometropia and 20 myopic anisometropic amblyopia, 10 astigmatic amblyopic) were included in this study, Levodopa was administered daily for 6 weeks associated with occlusion therapy and visual training. The drug was stopped and patients continued on occlusion therapy associated with visual training for another 6 weeks. Then gradual reduction of occlusion time and visual training was performed for a another 6 weeks, and finally all treatments were stopped for 6 weeks. Visual acuity and visual evoked potentials (VEP), including both multifocal VEP (MFVEP) and Pattern VEP (PVEP) were recorded before the treatment, at 1, 6, 12, 18, 24 weeks after beginning of treatment.
Results: Significant improvement of visual acuity (mean 0.50), with stabilization at the end of the 6th week associated with improved PVEP and MFVEP parameters was reported. Stabilization of the visual improvement after stoppage the treatment without any deterioration of vision or VEP parameters.
Conclusion: Improved visual acuity with stabilization can be achieved with combined Levodopa, occlusion and visual training therapy confirmed with VEP improvement.
Keywords: Amblyopia; Eye; Visual Evoked Responses (VEP)
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