Acta Scientific Ophthalmology (ISSN: 2582-3191)

Review Article Volume 5 Issue 6

Ophthalmologic Manifestations in Schizophrenic Patients: A Review of the Literature

Marina Maria Gonzaga Moreira1*, Letícia Brandão Barbosa de Oliveira1, Carlos Eduardo Ximenes da Cunha1, Marina Viegas Moura Rezende Ribeiro2 and Allan Maia Andrade de Souza3

1Medical Intern, Tiradentes University Center, Maceió-Alagoas, Brazil
2Doctor in Health Sciences, Professor of the Tiradentes University Center, Maceió-Alagoas; Specialist in Ophthalmology, Brazil
3Psychotherapist, Professor of the Tiradentes University Center, Maceió-Alagoas; Specialist in Psychiatry, Brazil

*Corresponding Author: Marina Maria Gonzaga Moreira, Medical Intern, Tiradentes University Center, Maceió-Alagoas, Brazil.

Received: April 24, 2022; Published: May 02, 2022

Abstract

Introduction: Schizophrenia is a severe psychiatric disorder characterized by various psychotic manifestations. The relationship between this disorder and ophthalmologic dysfunctions is well described in the literature. Examples of this are the numerous retinal alterations in schizophrenics and the deficits in visual perception. In addition, chronic use of antipsychotics can lead to several ophthalmologic manifestations.

Objective: To identify and explain the main ophthalmologic manifestations caused by schizophrenia and antipsychotic treatment.

Methods: This is an integrative literature review, using papers published in the last 20 years in the LILACS, SCIELO, PUBMED, Psycoinfo, Scopus and Google Schoolar databases. The review was produced in January 2021 using 18 scientific articles.

Results and Discussion: Based on the analysis of the data, the main findings were the changes in the retina, eye movement and visual perception in schizophrenic patients. The effects of antipsychotics on vision were also noted. It was observed that excessive dopaminergic activity generates hypersensitivity to color and compromises synaptic transmission in the retina. Antipsychotics, in chronic use, are able to generate damage and atrophy of the retinal pigment epithelium and elevate intraocular pressure (IOP). Moreover, it was noted characteristic abnormalities in eye movements and visual perception in schizophrenics.

Conclusion: Ophthalmologic involvement is one of the most important features of schizophrenia. Despite the existence of studies that prove the relationship between vision problems and schizophrenia, there is still a need for further research for a better understanding of the ophthalmologic consequences in these patients

Keywords: Schizophrenia; Ophthalmology; Retina; Distortion of Perception; Antipsychotics

References

  1. American Psychiatric Association. DSM-5 (2016).
  2. Jair J Mari and Raquel J Leitão. “A epidemiologia da esquizofrenia”. Brazilian Journal of Psychiatry Maio (2019).
  3. Tandon R., et al. “Definition and description of schizophrenia in the DSM-5”. Schizophrenia Research 1 (2013): 3-10.
  4. SM Silverstein and R Rosen. “Schizophrenia and the eye”. Junho (2015).
  5. Steven M Silverstein., et al. “Schizophrenia and the retina: Towards a 2020 perspective”. Schizophrenia Research Maio 219 (2020): 84-94.
  6. Souza and de Moura Filho., et al. “Intraocular pressure in schizophrenic patients treated with psychiatric medications”. Arquivos Brasileiros de Oftalmologia 5 (2008): 660-664.
  7. R H Masland. “The fundamental plan of the retina”. Setembro (2001).
  8. Selin A Adams and Henry A Nasrallah. “Multiple retinal anomalies in schizophrenia”. Maio (2018).
  9. Wójciak P., et al. “Dysfunctions of the retina and other elements of the visual system in schizophrenia”. Psychiatria Polska4 (2020): 673-686.
  10. Jurišić D., et al. “New Insights into Schizophrenia: a Look at the Eye and Related Structures”. Psychiatria Danubina 1 (2020): 60-69.
  11. A Tan., et al. “Étude de la structure et de la fonction rétinienne chez les patients atteints de trouble dépressif sévère, de trouble bipolaire ou de schizophrénie : une revue de la literature”. Agosto (2020).
  12. Meier MH., et al. “Microvascular abnormality in schizophrenia as shown by retinal imaging”. American Journal of Psychiatry12 (2013): 1451-1459.
  13. Spyridon Siafis and Dimitrios Tzachanis. “Antipsychotic Drugs: From Receptor-binding Profiles to Metabolic Side Effects”. (2018).
  14. Li J., et al. “Drug-induced ocular disorders”. Drug Safety2 (2008): 127-141.
  15. Razeghinejad MR. “Ocular adverse effects of common psychotropic agents: a review”. CNS Drugs11 (2010): 977; author reply 977-978.
  16. Richa S and Yazbek JC. “Ocular adverse effects of common psychotropic agents: a review”. CNS Drugs6 (2010): 501-526.
  17. Morita K., et al. “Eye movement characteristics in schizophrenia: A recent update with clinical implications”. Neuropsychopharmacology Report1 (2020): 2-9.
  18. Kentaro Morita., et al. “Eye movement characteristics in schizophrenia: A recent update with clinical implications”. Neuropsychopharmacology Report, Março (2020).
  19. Benson PJ., et al. “Simple viewing tests can detect eye movement abnormalities that distinguish schizophrenia cases from controls with exceptional accuracy”. Biology Psychiatry9 (2012): 716-724.
  20. King DJ., et al. “A review of abnormalities in the perception of visual illusions in schizophrenia”. Psychonomic Bulletin and Review 24 (2017): 734-751.
  21. Jahshan C., et al. “Probing the magnocellular and parvocellular visual pathways in facial emotion perception in schizophrenia”. Psychiatry Research 253 (2017): 38-42.
  22. Butler PD., et al. “Visual perception and its impairment in schizophrenia”. Biological Psychiatry1 (2008): 40-47.
  23. Martínez A., et al. “Magnocellular pathway impairment in schizophrenia: evidence from functional magnetic resonance imaging”. Journal of Neuroscience30 (2008): 7492-7500.
  24. Halide Bilge Türközer., et al. “Integrated assessment of visual perception abnormalities in psychotic disorders and relationship with clinical characteristics”. Psychological Medicine (2018).
  25. Gregory RL. “Distortion of visual space as inappropriate constancy scaling”. Nature 199 (1963): 678-680.
  26. Dima D., et al. “Understanding why patients with schizophrenia do not perceive the hollow-mask illusion using dynamic causal modelling”. Neuroimage4 (2009): 1180-1186.

Citation

Citation: Marina Maria Gonzaga Moreira., et al. “Ophthalmologic Manifestations in Schizophrenic Patients: A Review of the Literature".Acta Scientific Ophthalmology 5.6 (2022): 07-12.

Copyright

Copyright: © 2022 Marina Maria Gonzaga Moreira., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

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