Acta Scientific Ophthalmology (ISSN: 2582-3191)

Case Report Volume 5 Issue 6

Complete Closure of a Full-thickness Macular Hole Associated with Diabetic Macular Edema and Vitreo-retinal Adhesion During Treatment with Bevacizumab and Hemodialysis - A Case Report

Sahar Khayat1* and Basel Alahmar 2

1Family Medicine, Johns Hopkins Aramco, Saudi Arabia
2Opthalomology, Johns Hopkins Aramco, Saudi Arabia

*Corresponding Author: Sahar Khayat, Family Medicine, Johns Hopkins Aramco, Saudi Arabia.

Received: April 24, 2022; Published: May 2, 2022


Idiopathic full-thickness macular hole closure is a well-documented observation. Total posterior vitreous detachment is what presumed to lead to the macular hole closure. Diabetic retinopathy is known to worsen the prognosis of FTMH compared to that of an idiopathic etiology. We report a case of a 60-year-old male with severe non proliferative diabetic retinopathy, diabetic macular edema and epi-retinal membrane who developed a full-thickness macular hole. The patient had spontaneous closure of the macular hole during treatment with anti- vascular endothelial growth factor bevacizumab regular injections almost 6 months after starting 3 weekly hemodialysis for kidney failure.

Keywords: Macular Edema; Case Report; Hemodialysis; Diabetic Retinopathy; Retina


  1. “Macular Hole” - The American Society of Retina Specialists. (2021).
  2. Gass J D. “Idiopathic senile macular hole. Its early stages and pathogenesis”. Archives of Ophthalmology (Chicago, Ill. : 1960) 106.5 (1988): 629-639.
  3. Janson Ben J and Han IC. “Full-Thickness Macular Hole (FTMH)”. November 22, (2017).
  4. Konstantinidis Aristeidis., et al. “Efficacy of autologous platelets in macular hole surgery”. Clinical Ophthalmology (Auckland, N.Z.) 7 (2013): 745-750.
  5. Ezra Eric., et al. “Surgery for idiopathic full-thickness macular hole: two-year results of a randomized clinical trial comparing natural history, vitrectomy, and vitrectomy plus autologous serum: Morfields Macular Hole Study Group RAeport no. 1”. Archives of Ophthalmology (Chicago, Ill. : 1960) 122.2 (2004): 224-236.
  6. Reinherz Benjamin J and Jeffrey S Rubin. “Spontaneous Closure of a Full-Thickness Macular Hole Associated with Proliferative Diabetic Retinopathy and Persistent Vitreomacular Traction”. Case Reports in Ophthalmology1 (2016): 163-166.
  7. Errera Marie-Hélène., et al. “Spontaneous macular hole closure without posterior vitreous detachment in a patient previously treated for diabetic maculopathy”. Acta Ophthalmologica2 (2013): e156-157.
  8. Gandorfer Arnd., et al. “Epiretinal pathology of diffuse diabetic macular edema associated with vitreomacular traction”. American Journal of Ophthalmology4 (2005): 638-652.
  9. Steel D H W and A J Lotery. “Idiopathic vitreomacular traction and macular hole: a comprehensive review of pathophysiology, diagnosis, and treatment”. Eye (London, England) 27.1 (2013): S1-21.
  10. Brazitikos, P D and N T Stangos. “Macular hole formation in diabetic retinopathy: the role of coexisting macular edema”. Documenta Ophthalmologica. Advances in Ophthalmology3-4 (1999): 273-278.
  11. Gass J D. “Reappraisal of biomicroscopic classification of stages of development of a macular hole”. American Journal of Ophthalmology 119,6 (1995): 752-759.
  12. Yang Sung Jae., et al. “Changes of choroidal thickness, intraocular pressure and other optical coherence tomographic parameters after haemodialysis”. Clinical and Experimental Optometry5 (2013): 494-499.
  13. Ulaş Fatih., et al. “Evaluation of choroidal and retinal thickness measurements using optical coherence tomography in non-diabetic haemodialysis patients”. International Ophthalmology5 (2013): 533-539.
  14. Lior Lipsky., et al. “The influence of hemodialysis treatment on retinal thickness and macular edema in patients with diabetic retinopathy”. Investigative Ophthalmology and Visual Science 54 (2013): 2436.
  15. Chang In Boem., et al. “Changes in choroidal thickness in and outside the macula after hemodialysis in patients with end-stage renal disease”. Retina (Philadelphia, Pa.) 37.5 (2017): 896-905.
  16. Azem Nur., et al. “Effect of Hemodialysis on Retinal Thickness in Patients with Diabetic Retinopathy, with and without Macular Edema, Using Optical Coherence Tomography”. Journal of Ophthalmology 2014 (2014): 709862.


Citation: Sahar Khayat and Basel Alahmar. “Complete Closure of a Full-thickness Macular Hole Associated with Diabetic Macular Edema and Vitreo-retinal Adhesion During Treatment with Bevacizumab and Hemodialysis - A Case Report".Acta Scientific Ophthalmology 5.6 (2022): 02-06.


Copyright: © 2022 Sahar Khayat and Basel Alahmar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30th, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue".
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US