Delta and Omicron Variants
Isiaka Sanni Oluwasegun*
Department of Optometry and Vision Therapy, Makkah Specialist Eye Hospital Bauchi, Basar International Foundation, Nigeria
*Corresponding Author: Isiaka Sanni Oluwasegun, Department of Optometry and Vision Therapy, Makkah Specialist Eye Hospital Bauchi, Basar International Foundation, Nigeria.
Received:
January 20, 2022; Published: March 07, 2022
Abstract
The purpose of this paper is to review recent studies on Delta and Omicron variants of SARS-CoV-2 as to their symptoms, disease presentation and diagnosis, how they are affecting us and how ocular exposure routes influence disease presentation. Delta and Omicron have similar symptoms that sufferers present with, but shortness of breath is peculiar to the Delta variant and sneezing is not a symptom of Delta but of the Omicron variant infection. PCR and Antigen tests are usually done to diagnose SARS-CoV-2 if the disease is suspected but genomic sequencing (an expensive diagnostic test) is required to diagnose the Delta, Omicron, or the exact SARS-CoV-2 variant. The Delta variant (B.1.617.2) had invaded over 163 nations as of August, 2021 after it was discovered in India in late 2020. The Omicron SARS‐CoV‐2 variant may be more transmissible but less severe than the Delta variant form. The Delta VOC mostly endangers those who are unvaccinated or just partially vaccinated but the Omicron variant may be associated with increased risk of reinfection. In South Africa, the base of the Omicron variant, children seem to have been affected more with increase in number of hospitalizations among those children under age 5. A few cases of Delta variant infections reported had ocular manifestation including red bloodshot eye and conjunctivitis, but there may be a connection between chronic yet SARS-CoV-2 (Omicron variant) and neuroparalytic keratitis. Further studies into the ocular manifestation of these two VOCs and the susceptibility of the ocular surface as a route of entry may revolutionize our understanding of the two VOCs.
Keywords: SARS-CoV-2; Delta Variant; Omicron Variant; Ocular Surface
References
- Abebe EC., et al. “The newly emerged COVID‐19 disease: a systemic review”. Virology Journal1 (2020): 96.
- Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 395 (2020): 497-506.
- Lu R., et al. “Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding”. Lancet (2020).
- Chan JF., et al. “A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster”. Lancet 395 (2020): 514-523.
- Liu Y., et al. “Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals”. Nature 582 (2020): 557-560.
- Kumar S. “Drug and vaccine design against novel coronavirus (2019‐nCoV) spike protein through computational approach”. Preprints (2020).
- Letko M., et al. “Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses”. Nature Microbiology 5 (2020): 562-569.
- Lempp FA., et al. “Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies”. Nature 598 (2021): 342-347.
- Dudas G., et al. “Emergence and spread of SARS‐CoV‐2 lineage B.1.620 with variant of concern‐like mutations and deletions”. Nature Communication1 (2021): 5769.
- World Health Organization. COVID-19 Weekly Epidemiological Update Edition 68, published 30 November (2021).
- Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 395 (2020): 497-506.
- Kumar S. “Protein-protein interaction network for the identification of new targets against novel coronavirus”. In: Roy K, ed. In Silico Modeling of Drugs Against Coronaviruses: Computational Tools and Protocols. Springer (2021): 213‐
- Kumar S. “Online resource and tools for the development of drugs against novel coronavirus”. In: Roy K, ed. In Silico Modeling of Drugs Against Coronaviruses: Computational Tools and Protocols. New York, NY: Springer; 2021:735‐
- Kumar SM., et al. “COVID‐19 vaccine candidates by identification of B and T cell multi‐epitopes against SARS‐COV‐2”. Preprints (2020).
- Mahase E. “Delta variant: what is happening with transmission, hospital admissions, and restrictions?” BMJ 373 (2021): n1513.
- Chen Xuhui., et al. “SARS-CoV-2 on the ocular surface: is it truly a novel transmission route?”. British Journal of Ophthalmology9 (2021): 1190-1195.
- Zhou Lingli.. et al. "ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection”. The ocular surface4 (2020): 537-544.
- Zhao Hanjun., et al. "SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with delta variant in TMPRSS2-expressed cells: Omicron variant replication kinetics”. Emerging Microbes and Infectionsjust-accepted (2021): 1-18.
- World Health Organization. “Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern” (2021).
- Pandey SC., et al. "Vaccination strategies to combat novel corona virus SARS‐CoV‐2”. Life Science 256 (2020): 117956.
- Mencucci, Rita., et al. "Co-expression of the SARS-CoV-2 entry receptors ACE2 and TMPRSS2 in healthy human conjunctiva”. Experimental Eye Research205 (2021): 108527.
- Kumar S., et al. "Omicron and Delta variant of SARS‐CoV‐2: a comparative computational study of spike protein”. Journal of Medical Virology (2020).
- Johnson Bryan A., et al. "Furin cleavage site is key to SARS-CoV-2 pathogenesis”. BioRxiv (2020).
- Cameroni Elisabetta., et al. "Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift”. Nature (2021): 1-9.
- Zahradník, Jiří., et al. "SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution”. Nature Microbiology9 (2021): 1188-1198.
- Willett Brian J., et al. "The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism”. medRxiv (2022).
- Zhao Hanjun., et al. "SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with delta variant in TMPRSS2-expressed cells: Omicron variant replication kinetics”. Emerging Microbes and Infectionsjust-accepted (2021): 1-18.
- Pulliam Juliet RC., et al. "Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa”. MedRxiv (2021).
- World Health Organization. "COVID-19 weekly epidemiological update”. edition 74, 11 January 2022”. (2022).
- Wang Lindsey., et al. "COVID infection severity in children under 5 years old before and after Omicron emergence in the US”. medRxiv (2022).
- Debrowski Adam. “All About Vision”. 10 December (2021).
- Hong N., et al. "Evaluation of ocular symptoms and tropism of SARS-CoV-2 in patients confirmed with COVID-19”. Acta Ophthalmology (2020).
- Lu C., et al. "2019-nCoV transmission through the ocular surface must not be ignored”. Lancet 395 (2020): e39.
- Li Shengjie., et al. "SARS-CoV-2 receptor ACE2 is expressed in human conjunctival tissue, especially in diseased conjunctival tissue”. The Ocular Surface19 (2021): 249.
- Ma Di., et al. "Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea”. Eye7 (2020): 1212-1219.
- Hoffmann Markus., et al. "SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor”. Cell2 (2020): 271-280.
Citation
Copyright