Acta Scientific Ophthalmology (ISSN: 2582-3191)

Case Report Volume 5 Issue 3

Complications and Management of the Excessive Fibrin Glue in Anterior Chamber: Case Report

Ozlem Barut Selver1, Ilayda Korkmaz1 and Melis Palamar2*

1Associate Professor, M.D., Ege University, Department of Ophthalmology, Izmir, Turkey
2M.D., Ege University, Department of Ophthalmology, Izmir, Turkey

*Corresponding Author: Melis Palamar, Associate Professor, M.D., Ege University, Department of Ophthalmology, Izmir, Turkey.

Received: December 30, 2021; Published: February 28, 2022


A 36 year-old 9-week pregnant female presented with redness, pain and photophobia in the left eye. Best corrected visual acuity (BCVA) was 20/33. Slit-lamp examination revealed a 1.5 mm perforation area in the paracentral cornea. Fibrin glue was placed in the corneal perforation area for sealing and secured with bandage contact lenses. During the procedure, an excessive amount of fibrin glue was mistakenly injected into the anterior chamber (AC). On the postoperative first day, there was moderate AC reaction with raised intraocular pressure (IOP). Topical steroid and anti-glaucomatous treatment were administered. During the follow-up, complete dissolution of fibrin glue and regression of AC reaction was observed, and IOP went back to normal. Two weeks after fibrin glue injection, corneal integrity has achived and AC depth was normal with residual fibrin glue particles. BCVA increased to 20/25. Ocular findings remained stable during the follow-up for 18 months. Clinicians should be aware of the possible side effects of fibrin glue application. Careful observation and accurate management of the secondary complications are crucial to prevent further damage.

Keywords: Corneal Perforation; Fibrin Tissue Adhesive; Anterior Chamber; Intraocular Pressure


  1. Krysik K., et al. “Differences in Surgical Management of Corneal Perforations, Measured over Six Years”. Journal of Ophthalmology (2017): 1582532.
  2. Jhanji V., et al. “Management of corneal perforation”. Survey of Ophthalmology 56 (2011): 522-538.
  3. Moorthy S., et al. “Clinical experience with N-butyl cyanoacrylate tissue adhesive in corneal perforations secondary to herpetic keratitis”. Cornea9 (2010): 971‐975.
  4. Hick S., et al. “Amniotic membrane transplantation and fibrin glue in the management of corneal ulcers and perforations: a review of 33 cases”. Cornea 24 (2005): 369-377.
  5. Chew AC., et al. “Effect of intracameral injection of fibrin tissue sealant on the rabbit anterior segment”. Molecular Vision 16 (2010): 1087‐1097.
  6. Por YM., et al. “Intracameral fibrin tissue sealant as an adjunct in tectonic lamellar keratoplasty for large corneal perforations”. Cornea4 (2009): 451‐455.
  7. Celis J., et al. “Intracameral fibrin glue in spontaneous corneal perforation]”. Archivos de la Sociedad Española de Oftalmología 3 (2014): 124‐126.
  8. Scalcione C., et al. “Fibrin glue as agent for sealing corneal and conjunctival wound leaks”. Eye2 (2018): 463‐466.
  9. Sacchetti M and Lambiase A. “Diagnosis and management of neurotrophic keratitis”. Clinical Ophthalmology 8 (2014): 571-579.
  10. Siatiri Heidar MD., et al. “Use of Sealant (HFG) in Corneal Perforations”. Cornea 9 (2008): 988-991.


Citation: Melis Palamar., et al. “Complications and Management of the Excessive Fibrin Glue in Anterior Chamber: Case Report".Acta Scientific Ophthalmology 5.3 (2022): 74-76.


Copyright: © 2022 Melis Palamar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

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