Kulvinder Kochar Kaur¹*, Gautam Allahbadia² and Mandeep Singh³

¹Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
²Scientific Director, Rotunda - A Centre for Human Reproduction, Mumbai, India
³Consultant Neurologist, Swami Satyan and Hospital, Jalandhar, Punjab, India

*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.

Received: November 22, 2021; Published: January 17, 2022

Abstract

Curcumin represents a yellow polyphenolic pigment derived from the plant Curcuma longa (turmeric) rhizome that has been put in utilization over centuries for cuisine art besides coloring of foods, as a constituent of separate medicinal formulations that has been used over and over in Ayurveda along with Chinese medicine. In the current decades it has been exhaustively evaluated for its biological actions. Thus here we conducted a systematic review with the utilization of search engines like pubmed, google scholar, web of science, Cochrane library from 1900 till date with the utilization of MeSH terms Curcumin; Neuroinflammation; Alzheimer’s disease (AD); parkinson’s disease (PD); antioxidant actions; other anti-inflammatory actions; cardio protection; hepatoprotection in liver fibrosia; non alcoholic fatty liver disease (NAFLD); non alcoholic steatohepatitis (NASH); Anti cancer actions. We observed a total of over 3000 articles but selected only 53 articles for this review with the journals constraints of up to 50 references. No meta-analysis was done. Here we have reviewed in detail the mechanism of action of Curcumin in various above mentioned diseases along with transcription factors involved. Recently even in COVID its use has got documented. Although use in Alzheimer’s disease studied extensively human studies are still battling to get a concrete answer. In case of cancers, usually it is a good coagent with other chemotherapeutic drugs, might hamper human papilloma virus (HPV) infection as well as avoid cancer cervix generation. In case of NASH, or liver cirrhosis its use with beta blockers might aid in conversion back towards normalcy.

Keywords: Curcumin; Anti Inflammatory; Anti Oxidant; Neuro Shielding; Cardio Shielding; Hepatoprotection; Anti Cancer Actions

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Citation

Citation: Kulvinder Kochar Kaur., et al. “A Plethora of Actions of Curcumin - A Magical Agent for Treatment of Wide Range of Diseases Varying from Neuroinflammatory Disease (AD, PD)-IBD to DM and CVD, NAFLD, NASH Along with Various Cancers - A Systematic Review".Acta Scientific Ophthalmology 5.2 (2022): 09-19.

Copyright

Copyright: © 2022 Kulvinder Kochar Kaur., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.