Acta Scientific Ophthalmology (ISSN: 2582-3191)

Research Article Volume 5 Issue 1

Predictors of Sight Threatening ROP in a Tertiary Care Hospital of Himachal Pradesh

Praveen Kumar Panwar1*, Deepti Parmar2, Champa Panwar3 and Vibham Giulati4

1Associate Professor, Department of Ophthalmology, IGMC, Shimla, India
2Senior Resident, Department of Ophthalmology, IGMC, Shimla, India
3Medical Officer, Department of Pediatrics, DDU Zonal Hospital, Shimla, India
4Junior Resident, Department of Ophthalmology, IGMC, Shimla, India

*Corresponding Author: Praveen Kumar Panwar, Associate Professor, Department of Ophthalmology, IGMC, Shimla, India.

Received: September 13, 2021; Published: December 21, 2021

Abstract

Purpose: To study the incidence, patterns and risk factors of sight threatening ROP.

Methods: A hospital based prospective observational study was conducted from January 2019 to December 2019 at Indira Gandhi Medical College Shimla. 250 babies who fulfilled inclusion criteria’s were examined by an ophthalmologist at 3 weeks postnatal age. Baseline factors, systemic risk factors, and pattern of ROP were noted. Factors associated with sight threatening ROP including Type-1 ROP, Stage IV and V, were analyzed.

Results: Out of 250 babies screened 13.6% babies developed any type of ROP. The incidence of sight threatening ROP was 9.2%.Out of 23 babies with ST- ROP Type -1 ROP was seen in 20 (86.95%) and advanced ROP (stage IV and V) in 3(13%). Mean gestational age, birth weight and duration of oxygen exposure for sight threatening ROP were 29.9 weeks and 1.23 kg, 23.83 ± 9.722 days respectively. Septicemia and respiratory Distress Syndrome found to be significant risk factors associated with ST- ROP. Late presentation was main cause of stage 4 and 5 disease.

Conclusion: Low birth weight, lower gestational age and duration of oxygen used were basic factors associated with development of ROP but risk factors like RDS and sepsis were found to be significant and independent risk factors for ST-ROP. These risk factors should be prevented or babies having these risk factors should be followed up regularly and treated effectively to stop the progression of disease.

Keywords: Sight Threatening-ROP; Respiratory Distress Syndrome; Septicemia

References

  1. Blencowe H., et al. “Preterm associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010”. Pediatric Research 74 (2013): 35.
  2. Blencowe H., et al. “Update on blindness due to retinopathy of prematurity globally and in India”. Indian Pediatrics 53 (2016): S 89-92.
  3. Pejawar R., et al. “National Neonatology Foundation’s Evidence-based Clinical Practise Guidelines (2010)”. Retinopathy of Prematurity, NNF India, New Delhi (2010): 253-262.
  4. Kulkarni S., et al. “Blinding retinopathy of prematurity in Western India: Characteristics of children, reasons for late presentation and impact on families”. Indian Pediatrics 55 (2018): 665-670.
  5. Meraz Gutiérrez MP., et al. “Evidence to modify guidelines for routine retinopathy of prematurity screening to avoid childhood blindness in middle income countries”. Revista Mexicana de Oftalmología 90 (2016): 167-173.
  6. Good WV, Early Treatment for Retinopathy of Prematurity Cooperative Group. “Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial”. Transactions of the American Ophthalmological Society 102 (2004): 233-248; discussion 248-250.
  7. Kumar P., et al. “Risk factors for severe retinopathy of prematurity in preterm low birth weight neonates”. Indian Journal of Pediatrics 78 (2011): 812-816.
  8. Murthy KR., et al. “Comparison of profile of retinopathy of prematurity in semiurban/rural and urban NICUs in Karnataka, India”. British Journal of Ophthalmology 97 (2013): 687-689.
  9. Murthy KR., et al. “Analysis of risk factors for the development of retinopathy of prematurity in preterm infants at a tertiary referral hospital in South India”. Acta Medica Lituanica 13 (2006): 147-151.
  10. Chaudhari S., et al. “Retinopathy of prematurity in a tertiary care center - Incidence, risk factors and outcome”. Indian Pediatrics 46 (2019): 219-224.
  11. Ashok KM., et al. “A study of risk factors for retinopathy of prematurity in a medical college hospital in South India to evaluate the criteria for screening for retinopathy of prematurity”. Journal of Current Trends in Clinical Medicine and Laboratory Biochemistry 2 (2014): 31-36.
  12. Charan R., et al. “Incidence of retinopathy of prematurity in a neonatal care unit”. Indian Journal of Ophthalmology 43 (1995): 123-126.
  13. Hungi B., et al. “Retinopathy of prematurity in a rural Neonatal Intensive Care Unit in South India‑‑ A prospective study”. Indian Journal of Pediatrics 79 (2012): 911-915.
  14. Dwivedi A., et al. “Prevalence, risk factors and pattern of severe retinopathy of prematurity in eastern Madhya Pradesh”. Indian Journal of Ophthalmology 67 (2019): 819-823.
  15. Vinekar A., et al. “Role of tele‑medicine in retinopathy of prematurity screening in rural outreach centers in India‑A report of 20,214 imaging sessions in the KIDROP program”. Seminars in Fetal and Neonatal Medicine 20 (2015): 335-345.
  16. International committee for the classification of retinopathy of prematurity. “The international classification of retinopathy of prematurity revisited”. Archives of Ophthalmology 123 (2005): 991-999.
  17. Shah PK., et al. “Aggressive posterior retinopathy of prematurity in large preterm babies in South India”. Archives of Disease in Childhood. Fetal and Neonatal Edition 97 (2012): F371-375.
  18. Vinekar A., et al. “Do platelets have a role in the pathogenesis of aggressive posterior retinopathy of prematurity”. Retina 30 (2010): S20-23.
  19. Flynn JT and Chan Ling T. “Retinopathy of prematurity: Two distinct mechanisms that underlie zone1 and zone 2 disease”. American Journal of Ophthalmology 142 (2006): 46-59.
  20. Saugstad OD and Aune D. “Optimal oxygenation of extremely low birth weight infants: a meta-analysis and systematic review of the oxygen saturation target studies”. Neonatology 105 (2014): 55-63.
  21. Joussen AM., et al. “A central role for inflammation in the pathogenesis of diabetic retinopathy”. Faseb Journal 18 (2004): 1450-1452.

Citation

Citation: Praveen Kumar Panwar., et al. “Predictors of Sight Threatening ROP in a Tertiary Care Hospital of Himachal Pradesh".Acta Scientific Ophthalmology 5.1 (2022): 38-42.

Copyright

Copyright: © 2022 Praveen Kumar Panwar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is November 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US