Acta Scientific Ophthalmology (ISSN: 2582-3191)

Research Article Volume 4 Issue 12

A Comparative Study: 36 Months Follow up Results of Accelerated Versus Conventional Corneal Collagen Cross-linking in Progressive Keratoconus Patients

Orjowan M Shalabi2, Yousef Shanti*1,2, Abd-Alfattah Arafat5, Reham H Shehada3, Basel M Shalabi2, Alaa I Dweikat2, Ibrahim Rabi2, Ahmed Meri2 and Jamal AS Qaddumi4

1Department of Ophthalmology, An-Najah National University Hospital, Nablus, Palestine
2Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
3Department of Ophthalmology, The Islamic Hospital, Amman, Jordan
4Department of Nursing, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
5Al-noor Center of Ophthalmology, Al-Arabi Hospital, Nablus, Palestine

*Corresponding Author: Yousef Shanti, Department of Ophthalmology, An-Najah National University Hospital, Nablus, Palestine.

Received: October 17, 2021 ; Published: November 09, 2021


Purpose: To compare the 36-month visual acuity, refraction, corneal topography, and corneal pachymetry outcomes of the conventional and accelerated corneal collagen crosslinking in progressive keratoconic eyes.

Methods: A prospective cohort study of 191 eyes of 76 patients. 91 eyes were treated with conventional crosslinking (C-CXL; 3mW/cm2 for 30 minutes), while 100 eyes were treated with accelerated crosslinking (A-CXL; 30mW/cm2 for 3 minutes). Preoperative and post-operative uncorrected (UCVA) and best corrected visual acuity (BCVA), spherical equivalent (SE), manifest refraction and corneal topography were evaluated and compared at different intervals of 3, 6, 12, 24 and 36 months.

Results: Both groups show significant improvement from baseline at final follow up in terms of uncorrected visual acuity. But the conventional method shows more improvement at final follow up (C-CXL; LogMAR 0.22, A-CXL; LogMAR 0.54, p = 0.03). There was no significant difference in terms of best corrected visual acuity. Both groups show insignificant improvement in spherical equivalent (SE) and cylinder. K1, K2 show comparable improvement in both groups, Kmean and Kmax show insignificant improvement from baseline in both groups. Central corneal thickness shows minimal change from baseline, with significant improvement by C-CXL (416.38 μm) over A-CXL (462.75 μm) (p = 0.028). No complications were detected in both groups.

Conclusion: Both conventional and accelerated CXL improved UCVA with more improvement at long-term follow up with the C-CXL. Entirely, C-CXL, as well as A-CXL, offers productive results in the strengthening of corneal tissue and disease stabilization.

Conclusion: The application of advanced analytic computer software engine allows for better planning of LASIK and provides an opportunity for a more efficient and safe protocol for management of patients. Reduction in overall diagnostics and the use of telemedicine also provided benefits to patients and similar outcomes, as compared to prior to the pandemic. No patients during the treatment period developed COVID-19 to our knowledge.

Keywords: Cross Linking; CXL; Keratoconus; Conventional; Accelerated; Visual; Topographic; Refractive Outcomes


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Citation: Yousef Shanti., et al. “A Comparative Study: 36 Months Follow up Results of Accelerated Versus Conventional Corneal Collagen Cross-linking in Progressive Keratoconus Patients".Acta Scientific Ophthalmology 4.12 (2021): 02-09.


Copyright: © 2021 Yousef Shanti., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

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