Acta Scientific Ophthalmology (ISSN: 2582-3191)

Research Article Volume 4 Issue 9

Retinopathy of Prematurity in Babies Born of Infertility Treatment- Cradle ROP Experience

Manoj Soman, Sameer I*, Anshuman Gahlot, Sheera K R, Abdul Nizar A P and Unnikrishnan Nair R

Chaithanya Eye Hospital and Research Institute, Thiruvananthapuram, Kerala, India

*Corresponding Author: Sameer I, Department of Vitreo-Retinal Service, Chaithanya Eye Hospital and Research Institute, Thiruvananthapuram, Kerala, India.

Received: August 10, 2021; Published: August 21, 2021


Purpose: To examine the incidence of Retinopathy of Prematurity (ROP) in children conceived through assisted reproductive techniques (ART) and to analyze whether the severity of ROP varied with babies born through natural conception.

Methods: This was a retrospective chart analysis of the CRADLE ROP data between September 2018 and April 2020 and included a multicentric NICU based neonatal screening for Retinopathy of Prematurity using the mobile Retcam Imaging system. Birth weight, gestational age, time of first examination, presence or absence of any stage of ROP, severity of the disease especially APROP and treatment were analyzed. Babies born through natural conception were compared with ART born babies.

Results: 492 Neonates were examined during this period. ROP was detected in 22.7% and treatment for ROP was advised in 21.4% neonates who developed ROP. 34 infants (6.9%) were born through assisted conception. Infants born through assisted conception accounted for 25% of all those infants requiring treatment. Out of those born through natural conception 22% (101 babies) developed ROP and 17.8% of these needed treatment. 32% (11 babies) of ART born babies developed ROP and 54% (6 babies) of these needed treatment. Bilateral APROP requiring anti-VEGF treatment was seen in 9% babies in the ART group compared to 1.9% in the other group. ROP that developed in ART babies were more in need of treatment than natural conception [OR - 5.33 (95% CI: 1.54, 18.47) with p-value < 0.05].

Conclusion: ART born babies make up a considerable proportion of the ROP babies who need treatment. Therefore, increased vigilance is required when screening babies conceived by assisted conception. With the demand for infertility treatment and use of assisted conception increasing, it can only be expected that this number will increase in future.

Keywords: Retinopathy of Prematurity (ROP); Assisted Reproductive Techniques (ART)


  1. Gogate P., et al. “Severe visual impairment and blindness in infants: causes and opportunities for control”. Middle East African Journal of Ophthalmology 18 (2011): 109-114.
  2. Chang JY., et al. “Decreasing trends of neonatal and infant mortality rates in Korea: compared with Japan, USA, and OECD nations”. Journal of Korean Medical Science9 (2011): 1115-1123.
  3. Augestad LB., et al. “Braille use among Norwegian children from 1967 to 2007: trends in the underlying causes”. Acta Ophthalmologica5 (2012): 428-434.
  4. Blencowe H., et al. “National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications”. Lancet 379 (2012): 2162-2172.
  5. Karna P., et al. “Retinopathy of prematurity and risk factors: A prospective cohort study”. BMC Pediatrics 5 (2005): 18.
  6. Azad R. “Prevention of blindness due to retinopathy of prematurity: A national movement”. Indian Journal of Pediatrics 81 (2014): 1373-1375.
  7. Puri S., et al. “Screening of retinopathy of prematurity: A neglected public health issue”. The Annals of Medical and Health Science Research 4 (2014): S65-66.
  8. Malhotra N., et al. “Assisted reproductive technology in India: A 3 year retrospective data analysis”. Journal of Human Reproductive Sciences4 (2013): 235-240.
  9. Minasian M and Fielder A. “IVF babies with severe retinopathy of prematurity at higher gestational age and birth weight: Implications of changing screening criteria”. British Journal of Ophthalmology8 (2005): 1066.
  10. McKibbin M and Dabbs TR. “Assisted conception and retinopathy of prematurity”. Eye 4 (1996): 476-478.
  11. Friling R., et al. “Retinopathy of prematurity in assisted versus natural conception and singlet on versus multiple births”. Ophthalmology 2 (2007): 321-324.
  12. Watts P and Adams GG. “In vitro fertilisation and stage 3 retinopathy of prematurity”. Eye3 (2000): 330-333.
  13. Funnell CL and Dabbs TR. “Assisted conception and retinopathy of prematurity: 8-year follow-up study”. Eye 3 (2007): 383-386.
  14. Chan RP., et al. “Association between assisted reproductive technology and advanced retinopathy of prematurity”. Clinical Ophthalmology 4 (2010): 1385-1390.
  15. Saunders RA., et al. “Racial variation in retinopathy of prematurity. The Cryotherapy for Retinopathy of Prematurity Cooperative Group”. Archives of Ophthalmology5 (1997): 604-608.
  16. Trifonova K., et al. “Artificial reproductive technology – a risk factor for retinopathy of prematurity”. Open Access Macedonian Journal of Medical Sciences6 (2018): 2245-2249.


Citation: Sameer I., et al. “Retinopathy of Prematurity in Babies Born of Infertility Treatment- Cradle ROP Experience".Acta Scientific Ophthalmology 4.9 (2021): 51-54.


Copyright: © 2021 Sameer I., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is May 20, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US