Acta Scientific Ophthalmology (ISSN: 2582-3191)

Research Article Volume 4 Issue 6

Analysis of Vitamin D Levels in Children with Progressive Myopia

Sowmya Raveendra Murthy1* and Nitya Raghu2

1Consultant, Department of Pediatric Ophthalmology and Strabismus, Sankara Eye Hospital, Bengaluru, India
2DNB Student, Sankara Eye Hospital, Bengaluru, India

*Corresponding Author: Sowmya Raveendra Murthy, Consultant, Department of Pediatric Ophthalmology and Strabismus, Sankara Eye Hospital, Bengaluru, India.

Received: April 26, 2021; Published: May 22, 2021

Abstract

Background: The increasing prevalence of myopia in children today deserves more exploration into the causes and possible modifiable factors. With the growing prevalence of vitamin D deficiency in India, and its effect on numerous body systems, we attempted to find a possible association between vitamin D deficiency and progressive myopia.

Aim: To analyse the vitamin D levels in children with progressive myopia.

Methods: This is a pilot study. Children with progressive myopia on treatment with low dose atropine showing progression (> 0.5D increase in last 6 months) were included to be a part of the study. Few of these children showed progression despite being on low dose atropine which prompted us to search further. Serum levels of vitamin D3 levels were ordered and analyzed.

Results: Total of 20 children, 9 boys and 11 girls, were included, all in the age group of 11 to 17 years. Low dose atropine eye drops were being used for more than a year in 17 children and rest for past 5 months. Serum vitamin D 3 levels were noted to be deficient (< 20 ng/ml) in 15 patients and insufficient (20 - 30 ng/ml) in 3 cases. Only 2 patients were noted to have normal levels above 30 ng/ml.

Conclusion: Our pilot study throws light on possibly using vitamin D 3 levels in our protocols in treating children with progressive myopia.

Keywords: Progressive Myopia; Vitamin D Deficiency; Atropine Eye Drops

References

  1. Sheeladevi S., et al. “Prevalence of Refractive Errors in Children in India: A Systematic Review”. Clinical and Experimental Optometry4 (2018): 495-503.
  2. Joseph S., et al. “Prevalence and risk factors for myopia and other refractive errors in an adult population in southern India”. Ophthalmic and Physiological Optics3 (2018): 346-358.
  3. Pan CW., et al. “Time Outdoors, Blood Vitamin D Status and Myopia: A Review”. Photochemical and Photobiological Sciences3 (2017): 426-432.
  4. Kwon JW., et al. “Epidemiologic Survey Committee of the Korean Ophthalmological Society. Serum 25-hydroxyvitamin D level is associated with myopia in the Korea national health and nutrition examination survey”. Medicine46 (2016): e5012.
  5. Chua WH., et al. “Atropine for the Treatment of Childhood Myopia”. Ophthalmology12 (2006): 2285-2291.
  6. Cuellar-Partida G., et al. “Genetically low vitamin D concentrations and myopic refractive error: a Mendelian randomization study”. International Journal of Epidemiology6 (2017): 1882‐1890.
  7. Tang SM., et al. “Vitamin D and its pathway genes in myopia: systematic review and meta-analysis”. British Journal of Ophthalmology1 (2019): 8-17.
  8. Kamboj P., et al. “Prevalence of hypovitaminosis D in India and way forward”. Indian Journal of Medical Research5 (2018): 548-556.
  9. Wilhelm JL., et al. “Low serum vitamin D is associated with axial length and risk of myopia in young children”. European Journal of Epidemiology 31 (2016): 491-499.
  10. Williams KM., et al. “Association Between Myopia, Ultraviolet B Radiation Exposure, Serum Vitamin D Concentrations, and Genetic Polymorphisms in Vitamin D Metabolic Pathways in a Multicountry European Study”. JAMA Ophthalmology1 (2017): 47-53.
  11. McMillan J. “Spectrum of Darkness, Agent of Light: Myopia, Keratoconus, Ocular Surface Disease, and Evidence for a Profoundly Vitamin D-dependent Eye”. Cureus6 (2018): e2744.
  12. Specht IO., et al. “Neonatal vitamin D status and myopia in young adult men”. Acta Ophthalmologica (2020).
  13. Annamaneni S., et al. “Association of vitamin D receptor gene start codon (Fok1) polymorphism with high myopia”. Oman Journal of Ophthalmology2 (2011): 57-62.
  14. Yam J C., et al. “Low-Concentration Atropine for Myopia Progression (LAMP) Study: A Randomized, Double-Blinded, Placebo-Controlled Trial of 0.05%, 0.025%, and 0.01% Atropine Eye Drops in Myopia Control”. Ophthalmology1 (2019): 113-124.

Citation

Citation: Sowmya Raveendra Murthy and Nitya Raghu. “Analysis of Vitamin D Levels in Children with Progressive Myopia".Acta Scientific Ophthalmology 4.6 (2021): 60-63.

Copyright

Copyright: © 2021 Sowmya Raveendra Murthy and Nitya Raghu. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 15, 2022.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US