Acta Scientific Ophthalmology (ISSN: 2582-3191)

Research Article Volume 4 Issue 6

The Effect of Mitomycin-C Application Time on Pterygium Recurrence After Surgical Excision

Pir Salim Mahar1*, Abdul Sami Memon2 and Israr Ahmed Bhutto3

1Professor of Ophthalmology and Dean, Isra Postgraduate Institute of Ophthalmology, Professor and Section Head, Director Glaucoma Service, Aga Khan University Hospital, Karachi, Pakistan
2Assistant Professor, Isra Postgraduate Institute of Ophthalmology, Aga Khan University Hospital, Karachi, Pakistan
3Associate Professor, Isra Postgraduate Institute of Ophthalmology, Karachi, Pakistan

*Corresponding Author: Pir Salim Mahar, rofessor of Ophthalmology and Dean, Isra Postgraduate Institute of Ophthalmology, Professor and Section Head, Director Glaucoma Service, Aga Khan University Hospital, Karachi, Pakistan.

Received: May 04, 2021; Published: May 11, 2021



Objective: The purpose of the study was to establish the safest and the most efficacious duration of application of MMC in patients undergoing primary pterygium excision to prevent recurrence.

Methods: An interventional study was carried out at Isra Postgraduate Institute of Ophthalmology/Al-Ibrahim Eye Hospital, Karachi, Pakistan from 2010 till 2017. Patients underwent surgical removal of pterygium using bare sclera method with MMC in concentration of 0.2 mg/ml (0.02%) with variable exposure time of 1 - 5 minutes. Classification of patients was done randomly with MMC application time ranging from 1 to 5 minutes. Patients were followed at 3, 6, 9 and 12 months postoperatively to record any recurrence.

Results: A total 273 eyes of male patients with mean age of 35.9 ± 1.23 years were included in the study. The overall pterygium recurrence rate at each follow-up was 5.66%, 6.92%, 7.90% and 9.3% at 3rd, 6th, 9th and 12th months respectively. There was a significant decline in recurrence in the number of patients with MMC application time of greater than 3 minutes at all follow-ups. Maximum of recurrence was seen in patients between 31 to 40 years at the final follow-up.

Conclusion: These results suggest that a MMC application time of less than 3 minutes increases the chances of pterygium recurrence after surgical excision. MMC application time of greater than 3 minutes is recommended to prevent recurrence of such high risk recurrent pathology.

Keywords: Pterygium; Recurrence; Mitomycin-C; Duration



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Citation: Pir Salim Mahar., et al. “The Effect of Mitomycin-C Application Time on Pterygium Recurrence After Surgical Excision".Acta Scientific Ophthalmology 4.6 (2021): 21-26.


Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

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