Abstract

Objective: The purpose of the study was to establish the safest and the most efficacious duration of application of MMC in patients undergoing primary pterygium excision to prevent recurrence.

Methods: An interventional study was carried out at Isra Postgraduate Institute of Ophthalmology/Al-Ibrahim Eye Hospital, Karachi, Pakistan from 2010 till 2017. Patients underwent surgical removal of pterygium using bare sclera method with MMC in concentration of 0.2 mg/ml (0.02%) with variable exposure time of 1 - 5 minutes. Classification of patients was done randomly with MMC application time ranging from 1 to 5 minutes. Patients were followed at 3, 6, 9 and 12 months postoperatively to record any recurrence.

Results: A total 273 eyes of male patients with mean age of 35.9 ± 1.23 years were included in the study. The overall pterygium recurrence rate at each follow-up was 5.66%, 6.92%, 7.90% and 9.3% at 3^rd, 6^th, 9^th and 12^th months respectively. There was a significant decline in recurrence in the number of patients with MMC application time of greater than 3 minutes at all follow-ups. Maximum of recurrence was seen in patients between 31 to 40 years at the final follow-up.

Conclusion: These results suggest that a MMC application time of less than 3 minutes increases the chances of pterygium recurrence after surgical excision. MMC application time of greater than 3 minutes is recommended to prevent recurrence of such high risk recurrent pathology.

Keywords: Pterygium; Recurrence; Mitomycin-C; Duration

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Citation

Citation: Pir Salim Mahar., et al. “The Effect of Mitomycin-C Application Time on Pterygium Recurrence After Surgical Excision".Acta Scientific Ophthalmology 4.6 (2021): 21-26.

Copyright

Copyright: © 2021 Pir Salim Mahar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.