Acta Scientific Ophthalmology (ISSN: 2582-3191)

Research Article Volume 4 Issue 2

Association Between Serum Vitamin-D Level and Dry Eye Syndrome - A prospective Cross-sectional Study

Prasenjit Saha1*, Tania Basaiawmoit2, J V Basaiawmoit3 and Anton Decruse Wanbah4

1Masters of Optometry, Bansara Eye Care Centre, Shillong, Meghalaya, India
2Vitreo Retina surgeon- Bansara Eye Care Hospital, Shillong, Meghalaya, India
3Medical Director and Founder, Bansara Eye Care Centre, Shillong, Meghalaya, India
4M.phil in Optometry, Bansara Eye Care Centre, Shillong, Meghalaya, India

*Corresponding Author: Prasenjit Saha, Bansara Eye Care Centre, Shillong, Meghalaya, India.

Received: December 19, 2020; Published: January 30, 2021



Aim: This study is to investigate the association between the patients with dry eye syndrome and serum vitamin D level in hospital-based population.

Study Design: Prospective, cross-sectional study.

Methods: 88 participants (including male and female) diagnosed with Dry Eye Syndrome having no ocular diseases or any auto-immune systemic diseases were included. Comprehensive eye examination was done for all subjects. OSDI questionnaire, Schirmer’s Test I and II and Tear Break up Time (TBUT) along with the measurement of Serum vitamin D level were performed for all the subjects. Analyses were made using the SPSS.

Results: The mean age of the participants was 37.67 ± 14.17 years (95% CI: 34.92-40.65). Mean ST-I was found to be 8.54 ± 3.43mm (95% CI: 34.92-40.65), mean OSDI score was 45.80 ± 9.74 (95% CI: 43.76-47.80), mean ST-II was 5.86 ± 2.92mm (95% CI: 5.30-6.34), mean TBUT was 5.98 ± 2.23 seconds (95% CI: 5.47-6.47) and Serum Vit-D level was 20.21 ± 9.24 ng/ml (95% CI: 18.06-21.98). Statistically significant difference was observed between ST-I and ST-II (P ˂ 0.001). Regression analysis showed a significant association for OSDI (r = 0.938, p ˂ 0.001), ST-II (r = 0.28, p ˂ 0.04) and TBUT (r = 0.64, p ˂ 0.001) with Serum Vit-D level.

Conclusion: In our study, OSDI score, low tear secretion level and tear break up time suggested to show significantly low Serum Vitamin-D concentration in blood which may be the contributory factor for DES. The results of the study suggest that serum Vit-D supplementation can be a useful and effective treatment of DES.

Keywords: Cross Sectional Study; OSDI Questionnaire; Dry Eye Syndrome; Tear Secretion; Serum 25 Hydroxyvitamin-D Level



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Citation: Prasenjit Saha., et al. “Association Between Serum Vitamin-D Level and Dry Eye Syndrome - A prospective Cross-sectional Study".Acta Scientific Ophthalmology 4.2 (2021): 45-55.


Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

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