Aim: This study aimed to compare peripapillary retinal nerve fiber layer (RNFL) and macular retinal ganglion cell-inner plexiform layer (GC-IPL) changes in patients with primary open-angle glaucoma with control subjects by Swept Source optical coherence tomography.

Methods: This was a comparative cross-sectional study included 40 eyes of 40 POAG and 40 eyes of 40 control subjects. Ophthalmic examination, measurement of intraocular pressure, Visual field evaluation by using Humphrey (2003 Carl Zeiss Meditec, Germany) were done. All subjects were scanned using swept source Optical Coherence Tomography (Triton, Topcon, Tokyo, Japan) imaging to measure Macular GC-IPL thickness, peripapillary RNFL thickness.

Results: The mean age of the patients with POAG was 58.20 ± 9.12 years; 26 eyes (65.0%) were male and 14 eyes (35.0%) were female. The mean age of control subjects was 54.10 ± 9.11 years. The mean visual field MD was -11.30 ± 6.88 db, SE was -3.43 ± 1.08 D, CMT was 164.3 ± 16.62 Um and IOP was 15.25 ± 1.33 mmHg in patients with POAG, whereas mean visual field MD was -0.97 ± 0.39 db, SE was -3.23 ± 1.04 D, CMT was 170.6 ± 9.21 Um and IOP was 13.20 ± 1.18 mmHg in control subject. A statistically significant difference of IOP, visual field MD was detected between the study groups with p value (p < 0.001). the Mean Macular GC-IPL thickness and peripapillary RNFL thickness were significantly decrease in POAG patients when compared with controls (p < 0.001).

Conclusion: Retinal nerve fiber layer and ganglion cell-inner plexiform Layer by Swept-source OCT showed statistically significant decrease in POAG patients.

Keywords: RNFL; Macular GC-IPL; OCT; POAG

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Citation

Citation: Asaad A Ghanem., et al. “Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Loss in Patients with Primary Open Angle Glaucoma”. Acta Scientific Ophthalmology 3.7 (2020): 29-35.

Copyright

Copyright: © 2020 Asaad A Ghanem., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.