Avellino is a corneal dystrophy with granular deposits in the subepithelial and anterior stromal corneal layers, combined with discernible lattice lines in the stroma. Vision decreases with age as the central visual axis becomes affected, and pain may accompany mild corneal erosions. The disease is more severe in homozygous patients than in their heterozygous counterparts, and mutations in TGFBI are responsible for the occurrence. Treatments vary by the depth of the opacities in the cornea and the availability of a graft, and phototherapeutic keratectomy (PTK) or keratoplasty has been used. We examined a family of 10 siblings; 8 were examined, and of these, 7 (3 males and 4 females) had the typical corneal opacities of Avellino dystrophy. Penetrating keratoplasty was performed on 4 eyes and the histopathological analysis of these grafts revealed them to be compatible with Avellino's dystrophy, with focal areas of irregular hyalinization in the anterior and posterior regions of the stroma, which a had tracery appearance and epithelial thickening.

Keywords:Avellino Corneal Dystrophy

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Citation

Citation: Livia Marinho de Farias., et al. “Avellino Corneal Dystrophy - Case Reports in A Family and Literature Review”.Acta Scientific Ophthalmology 3.1 (2020): 12-13.

Copyright

Copyright: © 2020 Livia Marinho de Farias., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.