Acta Scientific Ophthalmology (ASOP)

Short Communication Volume 3 Issue 1

Neurovascular, Eye and Systemic Capillary Anatomy: Could Clarkson’s Disease be Among Promising Prospective Testbeds to Even Better Understand Ourselves?

Diego Liberati*

Politecnico Di Milano University, National Research Council of Italy

*Corresponding Author: Diego Liberati, Politecnico Di Milano University, National Research Council of Italy.

Received: December 06, 2019; Published: December 30, 2019


  Systemic Capillary Leakage Syndrome (SCLS) - also known as Clarkson’s sydrome from the name of the clinician observing and reporting it first time few decades ago [1] - is a tricky quite rare syndrome [2-4]: few tens of subjects have been known worldwide, of which 13 have been treated here in Milano at Sacco University Hospital under the responsibility of the late Marco Cicardi, former professor and general director for Clinical Medicine, together with his Assistant Professors, mainly Maddalena Wu also studying correlations with Autonomous Nervous Systems through Hearth Rate Variablity analysis [5], and Gianmarco Podda on the patient bed.

  Causes are still unknown, and obviously there is no economical pharma interest in studying and possibly healing such a rare disease, but there is interest in governmental agencies, like our one, to invest little tax- payer money in order to better understand such pathology, that could also be informative about underlying physiology, as usual. The main evident effect is that, apparently asynchronously within life, repeatedly, and suddenly, capillary bed starts leaking all over the body – as opposite to local inflammatory diseases – almost like a general menstruation not involving just endometrium nor even just females.



  1. Bayard Clarkson., et al. “Cyclical edema and shock due to increased capillary permeability”. The American Journal of Medicine2 (1960):193-216.
  2. Xie Z., et al. “Vascular endothelial hyper-permeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)”. Blood18 (2012): 4321-4332.
  3. Prashant Kapoor., et al. “Idiopathic Systemic Capillary Leak Syndrome (Clarkson's Disease): The Mayo Clinic Experience”. Mayo Clinic Proceedings 10 (2010): 905-909.
  4. Albert C Sek., et al. “Long, Celeste Nelson, Arkadiusz Z. Dudek, and Kirk M. Druey: Endothelial Expression of Endothelin Receptor A in the Systemic Capillary Leak Syndrome”. PLoS One7 (2015): e0133266.
  5. G Baselli., et al. “Spectral and cross-spectral analysis of heart rate and arterial blood pressure variability signals”. Computers and Biomedical Research6 (1986): 520-534.
  6. A Lunghi., et al. “A rare syndrome as a priming for scientific research”. Internal Report CNR_IEIIT_Mi_Liberati (2017).
  7. Davide Mezza., et al. “A quantitative numerical model for TNF-α mediated cellular Apoptosis”. Biology, Engineering and Medicine 1 (2016): 1-8.
  8. Diego Liberati., et al. “Systemic Capillary Leakege Syndrome: a proposal to Funding for Italian Research and Science”. CNR_IEIIT_Mi_Liberati Internal Report (2019).
  9. G Ferrari-Trecate., et al. “A clustering technique for the identification of piecewise affine systems”. Automatica 2 (2003), 205-217.
  10. M Muselli and D Liberati. “Binary rule generation via Hamming Clustering”. IEEE Transactions on Knowledge and Data Engineering6 (2002): 1258-1268.
  11. S Grassi., et al. “The Wnt Pathway is Relevant for the BCR-ABL-1 Independent Resistance in Chronic Myeloid Leukemia”. Frontiers in Oncology 9 (2019): 532.


Citation: Diego Liberati. “Neurovascular, Eye and Systemic Capillary Anatomy: Could Clarkson’s Disease be Among Promising Prospective Testbeds to Even Better Understand Ourselves?”.Acta Scientific Ophthalmology 3.1 (2020): 12-13.


Acceptance rate35%
Acceptance to publication20-30 days
ISI- IF1.042
JCR- IF0.24

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