Zeba un-Naher*, Razana Faiz, Fatema Alzahraa, Sheeza Ali, Sheena Moosa, Kannan Subbaram, Muktar Ali, KM Huria Parveen and Aminath Huda

MD in Clinical Biochemistry, Assistant professor in Biochemistry, School of Medicine, Maldives National University, Male’, Maldives

*Corresponding Author: Zeba un-Naher, MD in Clinical Biochemistry, Assistant professor in Biochemistry, School of Medicine, Maldives National University, Male', Maldives.

Received: February 17, 2025; Published: March 05, 2025

Abstract

Folate and homocysteine levels affect both reproductive health and well-being in pregnancy. The aim of this study is to evaluate the involvement of demographic factors in the folate and homocysteine status of women of reproductive age. The findings show that young age, single marital status, and higher educational levels are all associated with increased folate deficiency, as was found before.

In addition, women with menstrual irregularities had elevated homocysteine levels, and this link between homocysteine metabolism and reproductive health has not been explored. Several previous studies have emphasized the importance of further study of the impact of homocysteine and vitamin B12 deficiency on recurrent pregnancy loss.

Also, being previously related to cardiovascular and reproductive risks, the MTHFR C677T polymorphism was taken into consideration. A meta-analysis showed that people with the TT genotype are at high risk of coronary heart disease, especially if folate intake is low. The key to metabolic health, this finding puts forth, is also genetic and nutritional crosstalk.

The study points to the need for directed intervention to increase folate intake and control the levels of homocysteine among at-risk populations. Education based on diet, supplementation programs, and genetic screening are some strategies that can facilitate reproductive health outcomes. There is much more groundwork to be laid in understanding biological mechanisms undergirding these associations and the evidence for public health guidelines that follow.

Folate, homocysteine, women’s health, demographic factors, menstrual irregularities

 Keywords: Folate Deficiency; Homocysteine; MTHFR C677T Polymorphism; Nutritional Interventions

References

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Citation

Citation: Zeba un-Naher., et al. “Demographic Influences on Folate and Homocysteine Status in Women of Reproductive Age Attending the Maldives National University”.Acta Scientific Medical Sciences 9.4 (2025): 13-19.

Copyright

Copyright: © 2025 Zeba un-Naher., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.