Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Editorial Volume 9 Issue 2

Towards the Correct Path for the Development of an Antidote for Phosphine Poisoning

Sawani1, Sumanpreet Kaur2, Deepak Yadav2, Deepak Kumar2, Rajasri Bhattacharyya2 and Dibyajyoti Banerjee2*

1VPOI Madina, Rohtak, Haryana 12400, India
2Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India

*Corresponding Author: Dibyajyoti Banerjee, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Received: January 10, 2025; Published: February 01, 2025

Abstract

Like Organophosphorus pesticide poisoning, aluminium phosphide (AlP) poisoning is a public health concern https://pubmed.ncbi.nlm.nih.gov/37805177/ [1]. It is commonly used for grain storage and is available to the public in the open market. Therefore, suicidal, homicidal, and accidental poisoning due to aluminium phosphide is often heard. The culprit of AlP is phosphine which is liberated from aluminium phosphide inside the human body. Phosphine is known to cause mitochondrial toxicity. It is generally lethal without any known antidote https://doi.org/10.1016/j.cca.2021.05.026 [2] https://pubmed.ncbi.nlm.nih.gov/24508992/ [3].

References

  1. Kaur S., et al. “Organophosphorus and carbamate pesticides: Molecular toxicology and laboratory testing”. Clinical Chimica Acta 551 (2023): 117584.
  2. Deepak Yadav., et al. “Acute aluminum phosphide poisoning: The menace of phosphine exposure”. Clinical Chimica Acta 520 (2021): 34-42.
  3. Chowdhary S., et al. “Acute organophosphorus poisoning”. Clinical Chimica Acta 431 (2014): 66-76.
  4. Alzahrani SM and Ebert PR. “Pesticidal Toxicity of Phosphine and Its Interaction with Other Pest Control Treatments”. Current Issues in Molecular Biology 45 (2023): 2461-2473.
  5. Solgi Reza and Mohammad Abdollahi. "Proposing an antidote for poisonous phosphine in view of mitochondrial electrochemistry facts". Journal of Medical Hypotheses and Ideas1 (2012): 32-34.
  6. Karimani A., et al. “Antidotes for aluminum phosphide poisoning - An update”. Toxicology Report 5 (2018): 1053-1059.
  7. Moghadamnia AA. “An update on the toxicology of aluminum phosphide”. Daru 1 (2012): 25.
  8. Agrawal VK., et al. “Aluminum phosphide poisoning: Possible role of supportive measures in the absence of specific antidote”. Indian Journal of Critical Care Medicine 2 (2015): 109-112.
  9. Nath N S., et al. “Mechanisms of Phosphine Toxicity”. Journal of Toxicology (2011): 1-9.

Citation

Citation: Dibyajyoti Banerjee., et al. “Towards the Correct Path for the Development of an Antidote for Phosphine Poisoning”.Acta Scientific Medical Sciences 9.3 (2025): 01-02.

Copyright

Copyright: © 2025 ADibyajyoti Banerjee., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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