Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Clinical Review Volume 8 Issue 8

Solitary Fibrous Tumor of the Limbs – Our Experience and Current Knowledge

Razvan Ene1,2, Alexandru Duta2*, Sebastian Oprescu1,2, Liliana Mirea1,3, Alexandru Lisias Dimitriu1,2, Elisa Popescu1,2, Catalin Georgescu1,2 and Dragos Ene1,4

1Carol Davila University of Medicine and Pharmacy, 8th Eroii Sanitari, Bucharest, Romania
2Department of Orthopedics and Trauma, Clinical Emergency Hospital, Bucharest, 8th, Calea Floresca, Bucharest, Romania
3Department of Anesthesiology and Intensive Care, Clinical Emergency Hospital, Calea Floresca, Bucharest, Romania
4Department of Surgery, Clinical Emergency Hospital, Bucharest, Romania, Calea Floresca, Bucharest, Romania

*Corresponding Author: Alexandru Lisias Dimitriu, Department of Orthopedics and Trauma, Clinical Emergency Hospital, Bucharest, 8th, Calea Floresca, Bucharest, Romania.

Received: July 02, 2024; Published: July 29, 2024

Abstract

Extra pleural solitary fibrous tumors are a very rare category of soft tissue derived neoplasm, that can occur anywhere in the body and that are most frequently benign. Their microscopic characteristics consist in a collagenous stroma and spindled-shaped cells disposed around dilated vasculatures that stain positive for CD34 and STAT6 in the immunohistochemistry analysis. We evaluated the current literature findings and compared them to our experience in treating a 68-year-old woman with a history of diabetes mellitus type 2, blood hypertension and chronic kidney disease presented with dull pain and discomfort on the posterior aspect of the right arm. After MRI evaluation, the patient underwent a block excision of the tumor, followed by surgical pathology examination coupled with immunohistochemistry (IMC) assessment, with a diagnostic for benign extra pleural solitary fibrous tumor. The postoperative evolution was uneventful, and at the 6- and 12-month post-op follow-up, the patient remained asymptomatic and no tumoral recurrence was signaled on the follow-up whole-body CT.

Keywords: Extra Pleural Solitary Fibrous Tumor; Immunohistochemistry; CD34; STAT6

References

  1. Meroni S., et al. “Solitary fibrous tumours: unusual aspects of a rare disease”. Hippokratia3 (2012): 269-274.
  2. Davanzo B., et al. “Solitary fibrous tumor”. Translational Gastroenterology and Hepatology 3 (2018): 94.
  3. Ronchi A., et al. “Extrapleural solitary fibrous tumor: A distinct entity from pleural solitary fibrous tumor. An update on clinical, molecular and diagnostic features”. Annals of Diagnostic Pathology 34 (2018): 142-150.
  4. Fukunaga M., et al. “Extrapleural solitary fibrous tumor: a report of seven cases”. Modern Pathology 5 (1997): 443-450.
  5. Thway K., et al. “Updates in the approach to intrathoracic sarcomas”. Histopathology 6 (2015): 755-770.
  6. Wang YX., et al. “Solitary Fibrous Tumors of the Lung: A Clinicopathological Analysis of 52 Cases”. Current Oncology2 (2023): 1784-1793.
  7. Thompson LDR., et al. “Orbit Solitary Fibrous Tumor: A Proposed Risk Prediction Model Based on a Case Series and Comprehensive Literature Review”. Head and Neck Pathology1 (2021): 138-152.
  8. Thompson LDR., et al. “Thyroid Gland Solitary Fibrous Tumor: Report of 3 Cases and a Comprehensive Review of the Literature”. Head and Neck Pathology4 (2019): 597-605.
  9. Dozier J., et al. “Massive malignant solitary fibrous tumor arising from the bladder serosa: a case report”. Journal of Medical Case Reports 9 (2015): 46.
  10. Lupescu O., et al. “Morphological landmarks of proximal humerus with impact in post-traumatic outcome”. Romanian Journal of Morphology and Embryology 4 (2016): 1273-1278.
  11. Fletcher CD. “The evolving classification of soft tissue tumours - an update based on the new 2013 WHO classification”. Histopathology1 (2014): 2-11.
  12. El-Helou E., et al. “Incidental finding of solitary fibrous tumor of male breast: case report and review of literature”. Romanian Journal of Morphology and Embryology4 (2022): 653-657.
  13. Ginat DT., et al. “Imaging features of solitary fibrous tumors”. AJR American Journal of Roentgenology3 (2011): 487-495.
  14. Demicco EG., et al. “Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model”. Modern Pathology9 (2012): 1298-1306.
  15. Fukasawa Y., et al. “Solitary fibrous tumor of the pleura causing recurrent hypoglycemia by secretion of insulin-like growth factor II”. Pathology International1 (1998): 47-52.
  16. Steigen SE., et al. “Expression of insulin-like growth factor 2 in mesenchymal neoplasms”. Modern Pathology7 (2009): 914-921.
  17. Musyoki FN., et al. “Solitary fibrous tumor: an update on the spectrum of extrapleural manifestations”. Skeletal Radiology1 (2012): 5-13.
  18. Briselli M., et al. “Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature”. Cancer 11 (1981): 2678-2689.
  19. Krishnakumar S., et al. “Solitary fibrous tumor of the orbit: a clinicopathologic study of six cases with review of the literature”. Survey on Ophthalmology5 (2003): 544-554.
  20. Abe S., et al. “Intramuscular solitary fibrous tumor: a clinicopathological case study”. Journal of Computer Assisted Tomography 3 (1999): 458-462.
  21. Biedrzycki OJ., et al. “Solitary fibrous tumor of the female genital tract a case report and review of the literature”. International Journal of Gynecological Pathology3 (2007): 259-264.
  22. Tisler CE., et al. “Human Enamel Fluorination Enhancement by Photodynamic Laser Treatment”. Polymers (Basel)14 (2022).
  23. Tateishi U., et al. “Solitary fibrous tumor of the pleura: MR appearance and enhancement pattern”. Journal of Computer Assisted Tomography 2 (2002): 174-179.
  24. de Perrot M., et al. “Solitary fibrous tumors of the pleura”. Annals of Thoracic Surgery1 (2002): 285-293.
  25. Hara M., et al. “F-18 FDG uptake in a malignant localized fibrous tumor of the pleura”. Journal of Thoracic Imaging 2 (2005): 118-119.
  26. Migita K., et al. “Solitary fibrous tumor of the abdominal wall”. The International Journal of Clinical Oncology 6 (2009): 555-559.
  27. Kramer H., et al. “PET for the evaluation of pleural thickening observed on CT”. Journal of Nuclear Medicine6 (2004): 995-998.
  28. van Houdt WJ., et al. “Prognosis of solitary fibrous tumors: a multicenter study”. Annals of Surgical Oncology13 (2013): 4090-4095.
  29. Mirea L., et al. “Efficacy of tigecycline treatment in severe and complicated Clostridium difficile infection”. Therapy 65 (20172): 4.
  30. Ene R., et al. “Review of calcium-sulphate-based ceramics and synthetic bone substitutes used for antibiotic delivery in PJI and osteomyelitis treatment”. EFORT Open Review5 (2021): 297-304.
  31. González-Vargas PM., et al. “Hemangiopericytoma/Solitary Fibrous Tumor in the central nervous system. Experience with surgery and radiotherapy as a complementary treatment: A 10-year analysis of a heterogeneous series in a single tertiary center”. Neurocirugia (Astur : Engl Ed)1 (2020): 14-23.
  32. Gold JS., et al. “Clinicopathologic correlates of solitary fibrous tumors”. Cancer 4 (2002): 1057-1068.
  33. Thway K., et al. “The Current Status of Solitary Fibrous Tumor: Diagnostic Features, Variants, and Genetics”. International Journal of Surgical Pathology 4 (2016): 281-292.
  34. Tallini G., et al. “Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group”. Journal of Pathology2 (2002): 194-203.
  35. Chmielecki J., et al. “Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors”. Nature Genetics2 (2013): 131-132.
  36. Robinson DR., et al. “Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing”. Nature Genetics2 (2013): 180-185.
  37. Popescu D. ER., et al. “Total Hip Joint Replacement in Young Male Patient with Osteoporosis Secondary to Hypogonadotropic Hypogonadism”. Acta Endo (Buc) 11 (2015): 109-113.
  38. Pavelescu D., et al. “The role of multimodal analgesia in the decrease of postoperative surgical stress response in major neoplastic thoraco-abdominal surgery”. Chirurgia (Bucur)6 (2011): 723-728.
  39. Fritchie K., et al. “The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma”. Acta Neuropathology2 (2019): 307-319.
  40. Machado I., et al. “Solitary Fibrous Tumor: Integration of Clinical, Morphologic, Immunohistochemical and Molecular Findings in Risk Stratification and Classification May Better Predict Patient outcome”. International Journal of Molecular Science17 (2021).
  41. Silvanto A., et al. “Primary hepatic solitary fibrous tumor with histologically benign and malignant areas”. Hepatobiliary and Pancreatic Diseases International6 (2015): 665-668.
  42. Reisenauer JS., et al. “Comparison of Risk Stratification Models to Predict Recurrence and Survival in Pleuropulmonary Solitary Fibrous Tumor”. Journal of Thoracic Oncology9 (2018): 1349-1362.
  43. Lupescu O., et al. “Acute cellulitis as local reaction to orthopedic implant - case presentation”. Romanian Journal of Morphology and Embryology 3 (2016): 1137-1143.
  44. Coppola G., et al. “Primary intraosseous solitary fibrous tumor: an extremely rare case report and brief review of the literature”. Pathologica5 (2022): 376-380.
  45. Al-Shanawani BN., et al. “A solitary fibrous tumor of the upper limb”. Saudi Medical Journal2 (2015): 236-238.
  46. Ge X., et al. “Solitary fibrous tumor of the ilium: A case report”. Medicine (Baltimore)51 (2017): e9355.
  47. Sbaraglia M., et al. “The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives”. Pathologica 2 (2021): 70-84.
  48. Viguer JM., et al. “Cytologic features of synovial sarcoma with emphasis on the monophasic fibrous variant: a morphologic and immunocytochemical analysis of bcl-2 protein expression”. Cancer 1 (1998): 50-56.
  49. Zhang YW., et al. “Solitary Fibrous Tumor of the Lumbar Spine Resembling Schwannoma: Case Report and Review of the Literature”. World Neurosurgery 124 (2019): 121-124.
  50. Lau SK., et al. “Myxoid solitary fibrous tumor: a clinicopathologic study of three cases”. Virchows Archiv2 (2009): 189-194.
  51. Li S., et al. “The relationship between the apparent diffusion coefficient and the Ki-67 proliferation index in intracranial solitary fibrous tumor/hemangiopericytoma”. Neurosurgery Review2 (2022): 1625-1633.
  52. Demicco EG., et al. “Risk assessment in solitary fibrous tumors: validation and refinement of a risk stratification model”. Modern Pathology 10 (2013): 1433-1442.
  53. Kazazian K., et al. “Toward Better Understanding and Management of Solitary Fibrous Tumor”. Surgical Oncology Clinics of North America 3 (2022): 459-483.
  54. Shmuly T., et al. “Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up”. Medicina (Kaunas)2 (2021).
  55. Baldi GG., et al. “Solitary fibrous tumor of all sites: outcome of late recurrences in 14 patients”. Clinical Sarcoma Research 3 (2013): 4.

Citation

Citation: Alexandru Lisias Dimitriu., et al. “Solitary Fibrous Tumor of the Limbs – Our Experience and Current Knowledge”.Acta Scientific Medical Sciences 8.8 (2024): 158-166.

Copyright

Copyright: © 2024 Alexandru Lisias Dimitriu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In





Contact US