Chloé Couzin¹*, Jérôme Leorza¹, Lilian Boissy², Wendy Turbant², Sandrine Roux¹, Richard Iapicco³, Caroline Izard² and Julia Gouvitsos¹

¹Etablissement Français du Sang Provence Alpes Côte d’Azur Corse, Site de délivrance, St Laurent du Var, France
²Etablissement Français du Sang Provence Alpes Côte d’Azur Corse, Site de délivrance, Marseille Baille, France
³Etablissement Français du Sang Provence Alpes Côte d’Azur Corse, Laboratoire de Contrôle Qualité, Marseille Vallée Verte, France

*Corresponding Author: Chloé Couzin, Etablissement Français du Sang Provence Alpes Côte d’Azur Corse, Site de délivrance, St Laurent du Var, France.

Received: May 29, 2024; Published: July 05, 2024

Abstract

Transfusion of platelet concentrate (PC) can be the cause of allergic side effects triggered by plasma constituents. To prevent such reactions, residual plasma is reduced and replaced with a substitute solution such as Intersol^®. Plasma proteins are largely eliminated (the level of residual extracellular proteins should be less than 0.5 g per product), reducing the risk of allergic reactions by up to 70%. Faced with a drop in platelet yields and the quantity of active products (QPA) following plasma reduced CP in 2022 at the EFS PACA Corse IH-DEL site in Nice, we carried out a causal analysis using the 5M method.

The initial quality of CP was assessed: age before processing, QPA and initial volume. The equipment and supplies used were checked, as was the sampling process. The human resources used for processing were analyzed. Compliance with the plasma reduced PC procedure and critical steps were examined through a survey of authorized technical staff.

This survey revealed a disparity in the application of the processing procedure leading to platelet loss through “platelet traps”. We thus identified stages at risk of the method. Revalidation of the plasma reduced PC process was carried out on 5 PCs in 2023. The quantity of residual protein in the product, the final QPA and the platelet yield were all found to be compliant. The drift in platelet yields after the deplasmatization of CPs in 2022 in the Nice lab provided an opportunity to review practices and raise awareness about platelet traps.

Keywords: Platelet Trap; 5M Model; Plasma Reduced Platelet Concentrate

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Citation

Citation: Chloé Couzin., et al. “Plasma Reduced Platelet Concentrate’s Hidden Face: Platelet Traps”.Acta Scientific Medical Sciences 8.8 (2024): 14-18.

Copyright

Copyright: © 2024 Chloé Couzin., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.