Dr. Anusha Sunder*

Doctorate in Lifescience/Human Nutrition, Accredited Certification in Nutrigenetics, Lead Scientist and Nutrigenetic Expert, Xcode Life Sciences, Pvt. Ltd. Chennai, India

*Corresponding Author: Dr. Anusha Sunder, Doctorate in Lifescience/Human Nutrition, Accredited Certification in Nutrigenetics, Lead Scientist and Nutrigenetic Expert, Xcode Life Sciences, Pvt. Ltd. Chennai, India.

Received: May 09, 2024; Published: May 27, 2024

Abstract

The latest edition of the International Diabetes Federation (IDF), the Diabetes Atlas displays the diabetes count in adults as nearly 463 million, with an additional 1.1 million children and adolescents having type 1 diabetes. The year 2010 projected global diabetes numbers to be 438 million in 2025. With a year still to go, that prediction has already been surpassed by 25 million [1].

References

1. International Diabetes Federation (IDF); Diabetes Atlas, 9th Edition, (2019).
2. International Diabetes Federation (IDF); Diabetes Atlas, 9th Edition. Worldwide toll of Diabetes (2019).
3. Alberti KG and Zimmet PZ. “Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation”. Diabetic Medicine7 (1998): 539-553.
4. https://www.who.int/genomics/about/Diabetis-fin.pdf
5. Mohan V., et al. “From Individualized to Personalized Medicine in Diabetes: An Expert Overview”. Journal of the Association of Physicians of India 9 (2019): 78-82.
6. Noble JA and Valdes AM. “Genetics of the HLA region in the prediction of type 1 diabetes”. Current Diabetes Reports 6 (2011): 533-542.
7. Eisenbarth GS. “Banting Lecture2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes”. Diabetes 59 (2010): 759-774.
8. Concannon P., et al. “Genetics of type 1A diabetes”. The New England Journal of Medicine 360 (2009): 1646-1654.
9. Noble JA., et al. “The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families”. American Journal of Human Genetics 59 (1996): 1134-1148.
10. Lambert AP., et al. “Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom”. The Journal of Clinical Endocrinology and Metabolism 89 (2004): 4037-4043.
11. Horton R., et al. “Gene map of the extended human MHC”. Nature Review Genetics 5 (2004): 889-899.
12. Aly TA., et al. “Genetic prediction of autoimmunity: initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetes”. Journal of Autoimmune 25 (2005): 40-45.
13. Aly TA., et al. “Extreme genetic risk for type 1A diabetes”. Proceedings of the National Academy of Sciences of the United States of America 103 (2006): 14074-14079.
14. Chung WK., et al. “Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)”. Diabetologia9 (2020): 1671-1693.
15. Xue Sun., et al. “Genetics of Type 2 Diabetes: Insights into the Pathogenesis and Its Clinical Application". BioMed Research International (2014).
16. Ali O. “Genetics of type 2 diabetes”. World Journal of Diabetes4 (2013): 114-123.
17. Florez JC., et al. “The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits”. Annual Review of Genomics and Human Genetics 4 (2003): 257-291.
18. Anık A., et al. “Maturity-onset diabetes of the young (MODY): an update”. Journal of Pediatric Endocrinology and Metabolism 3-4 (2015): 251-263.
19. Peixoto-Barbosa R., et al. “Update on clinical screening of maturity-onset diabetes of the young (MODY)”. Diabetology and Metabolic Syndrome 12 (2020): 50.
20. Rosik J., et al. “The role of genetics and epigenetics in the pathogenesis of gestational diabetes mellitus”. Annals of Human Genetics2 (2020): 114-124.
21. Shaat N and Groop L. “Genetics of gestational diabetes mellitus”. Current Medicinal Chemistry5 (2007): 569-583.
22. Greeley SA., et al. “Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment”. Current Diabetes Reports6 (2011): 519-532.
23. Lemelman MB., et al. “Neonatal Diabetes Mellitus: An Update on Diagnosis and Management”. Clinical Perinatology 1 (2018): 41-59.
24. Viswanathan Mohan and Ranjit Unnikrishnan. “Precision diabetes: Where do we stand today?” Indian Journal of Medical Research5 (2018): 472-475.

Citation

Citation: Dr. Anusha Sunder. “Role of Genes in Diabetes mellitus”.Acta Scientific Medical Sciences 8.6 (2024): 119-122.

Copyright

Copyright: © 2024 Dr. Anusha Sunder. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.