Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Systematic Review Volume 8 Issue 5

A Systematic Review of Clinical Studies Investigates the Role of Serum Prolactin Levels in Women with Uterine Fibroids

Azaz Ahmad1,2, Nihar Bhoi2, Manoj Kumar3, Sueba Salmani4, Akanksha Jangid5, Ramanand Sharma6, Vinod Kumar Patel7, Mohd Ajmal1, Juber Akhtar8and Mohammad Ahmad1*

1Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, India
2Department of Reproductive Medicine, Indira IVF Hospital Pvt. Ltd. Udaipur, India
3Department of Translational and Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India
4Department of Reproductive Medicine, Indira IVF Hospital Pvt. Ltd. Prayagraj, India
5Department of Reproductive Medicine, Indira IVF Hospital Pvt. Ltd. Kolkata, India
6Department of Pharmacy, Shyam University, Dausa, India
7Department of Pharmacology, Alwar Pharmacy College, Alwar, India
8Department of Pharmaceutics, Faculty of Pharmacy, Integral University, Lucknow, India

*Corresponding Author: Mohammad Ahmad, Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, India.

Received: March 25, 2024; Published: April 18, 2024


Background: Uterine fibroids are high-prevalence benign tumors originating from the smooth muscles of the uterus, noticed in approximately 70% of women of reproductive age. Prolactin is a hormone secreted from the anterior pituitary gland involved in various physiological functions, including lactogenesis and the regulation of reproductive functions. High serum prolactin levels may cause infertility and other reproductive disorders in women. Increasing evidence has focused on the critical pathogenetic role of prolactin in uterine fibroid diseases, as well as premalignant and malignant conditions. Subsequently, the objective of this current systematic review is to determine the status of serum prolactin in women of uterine fibroids.

Methods: In this systematic review, we comprehensively searched several databases, including PubMed, Google Scholar, and the Cochrane Library. A critical assessment has been conducted on articles related to the epidemiological and biological correlation of prolactin with uterine fibroids. Both observational and clinical trial studies were included from inception to March 15, 2024. The quality of the eligible studies was independently evaluated, retrieved, and assessed.

Results: Out of 275 studies, a total of 5 studies (1 Clinical Trial, 3 Case-Control, and 1 Cross-sectional) were included in this review. The 3 case-control studies concluded that serum prolactin levels are significantly higher in leiomyoma patients compared to healthy controls. Serum total protein and prolactin can be used as adjuvant biomarkers to confirm the diagnosis of uterine fibroids. Similarly, one cross-sectional study found a highly significant difference between prolactin levels in leiomyomas and in patients' myometrium. Additionally, a clinical trial revealed that patients' serum prolactin levels prior to surgery were significantly higher than post-surgery levels and higher than those in healthy, normal women. Furthermore, this clinical trial demonstrated a highly significant correlation between serum prolactin levels and their ratio with serum total protein. These results ensure and support the relationship between patients' serum prolactin and serum total protein levels with their fibroid numbers.

Conclusion: The evidence from available clinical studies suggests that uterine fibroids synthesize prolactin, and the ectopic production of prolactin from fibroid tissue results in a rise in serum prolactin levels, leading to infertility and other reproductive disorders that affect the quality of life. Hence, serum prolactin analysis should be taken into consideration in patients with uterine fibroids and infertility disorders. Furthermore diagnostic studies are required to validate the increased serum level of prolactin in women with uterine fibroids.

 Keywords: Prolactin; Uterine Fibroid; Leiomyomas; Myomas; Infertility; Biomarkers


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Citation: Azaz Ahmad., et al. “A Systematic Review of Clinical Studies Investigates the Role of Serum Prolactin Levels in Women with Uterine Fibroids”.Acta Scientific Medical Sciences 8.5 (2024): 54-62.


Copyright: © 2024 Azaz Ahmad., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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